ID   KLHL7_CHICK             Reviewed;         586 AA.
AC   Q5ZI33;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Kelch-like protein 7;
GN   Name=KLHL7; ORFNames=RCJMB04_30p4;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3
CC       ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating
CC       ubiquitination and subsequent degradation of substrate proteins.
CC       Probably mediates 'Lys-48'-linked ubiquitination (By similarity).
CC       {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Homodimer. Component of the BCR(KLHL7) E3 ubiquitin ligase
CC       complex (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8IXQ5}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q8IXQ5}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJ720951; CAG32610.1; -; mRNA.
DR   RefSeq; NP_001012875.1; NM_001012857.1.
DR   AlphaFoldDB; Q5ZI33; -.
DR   SMR; Q5ZI33; -.
DR   STRING; 9031.ENSGALP00000017779; -.
DR   PaxDb; Q5ZI33; -.
DR   GeneID; 420612; -.
DR   KEGG; gga:420612; -.
DR   CTD; 55975; -.
DR   VEuPathDB; HostDB:geneid_420612; -.
DR   eggNOG; KOG4441; Eukaryota.
DR   InParanoid; Q5ZI33; -.
DR   OrthoDB; 293214at2759; -.
DR   PhylomeDB; Q5ZI33; -.
DR   UniPathway; UPA00143; -.
DR   PRO; PR:Q5ZI33; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0031463; C:Cul3-RING ubiquitin ligase complex; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   GO; GO:0016567; P:protein ubiquitination; ISS:UniProtKB.
DR   Gene3D; 2.120.10.80; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR017096; BTB-kelch_protein.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR030599; KLHL7.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   PANTHER; PTHR24412:SF435; PTHR24412:SF435; 1.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 3.
DR   PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 4.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Kelch repeat; Nucleus; Reference proteome; Repeat;
KW   Ubl conjugation pathway.
FT   CHAIN           1..586
FT                   /note="Kelch-like protein 7"
FT                   /id="PRO_0000228991"
FT   DOMAIN          44..111
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          146..248
FT                   /note="BACK"
FT   REPEAT          294..336
FT                   /note="Kelch 1"
FT   REPEAT          337..382
FT                   /note="Kelch 2"
FT   REPEAT          383..430
FT                   /note="Kelch 3"
FT   REPEAT          431..481
FT                   /note="Kelch 4"
FT   REPEAT          483..528
FT                   /note="Kelch 5"
FT   REPEAT          530..575
FT                   /note="Kelch 6"
SQ   SEQUENCE   586 AA;  66196 MW;  E136CABC51C7991D CRC64;
     MAAPGSEKSS KKKTEKKLAA REEAKLLAGF MGVMNSMRKQ RTLCDVILMV QERRIPAHRV
     VLASASHFFN LMFTTNMLES KSFEVELKDA EPDIIEQLVE FAYTARISVN SNNVQSLLDA
     ANQYQIEPVK KMCVDFLKEQ VDASNCLGIS VLAECLDCPE LKATADDFIH QHFTEVYKTD
     EFLQLDVKRV THLLNQDTLT VRAEDQVYDA AVRWLKYDEP NRQPYMVDIL AKVRFPLISK
     NFLSKTVQAE PLIQDNPECL KMVISGMRYH LLSPEDREEL VEGTRPRRKK HDYRIALFGG
     SQPQSCRYFN PKDYSWTDIR CPFEKRRDAA CVFWDNVVYI LGGSQLFPIK RMDCYNVVKD
     SWYSKLGPPT PRDSLAACAA EGKIYTSGGS EVGNSALYLF ECYDTRTESW HTKPSMLTQR
     CSHGMVEANG LIYVCGGSLG NNVSRRVLNS CEVYDPATET WTELCPMIEA RKNHGLVFVK
     DKIFAVGGQN GLGGLDNVEY YDIKMNEWKM VSPMPWKGVT VKCAAVGSIV YVLAGFQGVG
     RLGHILEYNT ETDKWIANSK VRAFPVTSCL ICVVDTCGAN EETLET