ID   KLHL7_RAT               Reviewed;         586 AA.
AC   Q5XHZ6;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Kelch-like protein 7;
GN   Name=Klhl7;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3
CC       ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating
CC       ubiquitination and subsequent degradation of substrate proteins.
CC       Probably mediates 'Lys-48'-linked ubiquitination (By similarity).
CC       {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Homodimer. Component of the BCR(KLHL7) E3 ubiquitin ligase
CC       complex, at least composed of CUL3 and KLHL7 and RBX1 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8IXQ5}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q8IXQ5}. Note=Colocalizes with CUL3 in punctate
CC       structures at the perinuclear region of the cytoplasm.
CC       {ECO:0000250|UniProtKB:Q8IXQ5}.
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DR   EMBL; BC083903; AAH83903.1; -; mRNA.
DR   RefSeq; NP_001012187.1; NM_001012187.1.
DR   AlphaFoldDB; Q5XHZ6; -.
DR   SMR; Q5XHZ6; -.
DR   STRING; 10116.ENSRNOP00000013932; -.
DR   PaxDb; Q5XHZ6; -.
DR   Ensembl; ENSRNOT00000013932; ENSRNOP00000013932; ENSRNOG00000010453.
DR   GeneID; 362303; -.
DR   KEGG; rno:362303; -.
DR   CTD; 55975; -.
DR   RGD; 1305564; Klhl7.
DR   eggNOG; KOG4441; Eukaryota.
DR   GeneTree; ENSGT00940000155602; -.
DR   HOGENOM; CLU_004253_14_2_1; -.
DR   InParanoid; Q5XHZ6; -.
DR   OMA; WRAASPM; -.
DR   OrthoDB; 293214at2759; -.
DR   PhylomeDB; Q5XHZ6; -.
DR   TreeFam; TF351653; -.
DR   UniPathway; UPA00143; -.
DR   PRO; PR:Q5XHZ6; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   Bgee; ENSRNOG00000010453; Expressed in quadriceps femoris and 20 other tissues.
DR   Genevisible; Q5XHZ6; RN.
DR   GO; GO:0031463; C:Cul3-RING ubiquitin ligase complex; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   GO; GO:0016567; P:protein ubiquitination; ISS:UniProtKB.
DR   Gene3D; 2.120.10.80; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR017096; BTB-kelch_protein.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR030599; KLHL7.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   PANTHER; PTHR24412:SF435; PTHR24412:SF435; 1.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 3.
DR   PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 4.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Kelch repeat; Nucleus; Reference proteome; Repeat;
KW   Ubl conjugation pathway.
FT   CHAIN           1..586
FT                   /note="Kelch-like protein 7"
FT                   /id="PRO_0000228990"
FT   DOMAIN          44..111
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          146..248
FT                   /note="BACK"
FT   REPEAT          294..336
FT                   /note="Kelch 1"
FT   REPEAT          337..382
FT                   /note="Kelch 2"
FT   REPEAT          383..430
FT                   /note="Kelch 3"
FT   REPEAT          431..481
FT                   /note="Kelch 4"
FT   REPEAT          483..528
FT                   /note="Kelch 5"
FT   REPEAT          530..575
FT                   /note="Kelch 6"
SQ   SEQUENCE   586 AA;  65970 MW;  732A600EBACBB2B3 CRC64;
     MATSGVEKSS KKKTEKKLAA REEAKLLAGF MGVMNNMRKQ RTLCDVILMV QERKIPAHRV
     VLAAASHFFN LMFTTNMLES KSFEVELKDA EPDIIEQLVE FAYTARISVN SNNVQSLLDA
     ANQYQIEPVK KMCVDFLKEQ VDASNCLGIS VLAECLDCPE LKSTADDFIH QHFTEVYKTD
     EFLQLDVKRV THLLSQDTLT VRAEDQVYDA AVRWLKYDEP NRQPFMVDIL AKVRFPLISK
     NFLSKTVQAE PLIQDNPECL KMVISGMRYH LLSPEDREEL AGGTRPRRKK HDYRIALFGG
     SQPQSCRYFN PKDYSWTDIR CPFEKRRDAA CVFWDNVVYI LGGSQLFPIK RMDCYNVVKD
     SWYSKLGPPT PRDSLAACAA EGKIYTSGGS EVGNSALYLF ECYDTRTESW HTKPSMLTQR
     CSHGMVEANG LIYVCGGSLG NNVSGRVLSS CEVYDPATET WTELCSMIEP RKNHGLVFVK
     DKIFAVGGQN GLGGLDNVEY YDIKLNEWKM VSPMPWRGVT VKCAAVGSVI YVLAGFQGVG
     RLGHILEYNT ETDKWVANSK VRAFPVTSCL ICVVDTCGAN EETLET