位置:首页 > 蛋白库 > KLK9_RAT
KLK9_RAT
ID   KLK9_RAT                Reviewed;         259 AA.
AC   P07647;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1988, sequence version 1.
DT   03-AUG-2022, entry version 147.
DE   RecName: Full=Submandibular glandular kallikrein-9;
DE            Short=rGK-9;
DE            EC=3.4.21.35;
DE   AltName: Full=KLK-S3;
DE   AltName: Full=S3 kallikrein;
DE   AltName: Full=Submandibular enzymatic vasoconstrictor;
DE            Short=SEV;
DE   AltName: Full=Tissue kallikrein;
DE   Contains:
DE     RecName: Full=Submandibular glandular kallikrein-9 light chain;
DE   Contains:
DE     RecName: Full=Submandibular glandular kallikrein-9 heavy chain;
DE   Flags: Precursor;
GN   Name=Klk9; Synonyms=Klk-9, Klks3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2998455; DOI=10.1021/bi00338a005;
RA   Ashley P.L., MacDonald R.J.;
RT   "Kallikrein-related mRNAs of the rat submaxillary gland: nucleotide
RT   sequences of four distinct types including tonin.";
RL   Biochemistry 24:4512-4520(1985).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   PROTEIN SEQUENCE OF 25-36 AND 112-122.
RC   TISSUE=Submandibular gland;
RX   PubMed=1900513; DOI=10.1016/s0021-9258(19)67749-5;
RA   Yamaguchi T., Carretero O.A., Scicli A.G.;
RT   "A novel serine protease with vasoconstrictor activity coded by the
RT   kallikrein gene S3.";
RL   J. Biol. Chem. 266:5011-5017(1991).
RN   [4]
RP   PROTEIN SEQUENCE OF 25-47 AND 112-135, AND CHARACTERIZATION.
RX   PubMed=1315752; DOI=10.1016/s0021-9258(19)50197-1;
RA   Moreau T., Brillard-Bourdet M., Bouhnik J., Gauthier F.;
RT   "Protein products of the rat kallikrein gene family. Substrate
RT   specificities of kallikrein rK2 (tonin) and kallikrein rK9.";
RL   J. Biol. Chem. 267:10045-10051(1992).
RN   [5]
RP   PROTEIN SEQUENCE OF 25-53 AND 112-130, AND CHARACTERIZATION.
RC   TISSUE=Submandibular gland;
RX   PubMed=1536657; DOI=10.1042/bj2810819;
RA   Berg T., Schoeyen H., Wassdal I., Hull R., Gerskowitch V.P., Toft P.;
RT   "Characterization of a new kallikrein-like enzyme (KLP-S3) of the rat
RT   submandibular gland.";
RL   Biochem. J. 281:819-828(1992).
CC   -!- FUNCTION: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in
CC       kininogen to release Lys-bradykinin. This enzyme has a vasoconstrictor
CC       activity. KLK-9 has both a chymotrypsin-like and a trypsin-like
CC       properties.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Preferential cleavage of Arg-|-Xaa bonds in small molecule
CC         substrates. Highly selective action to release kallidin (lysyl-
CC         bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-
CC         Xaa.; EC=3.4.21.35;
CC   -!- SUBUNIT: Heterodimer of a light chain and heavy chain linked by a
CC       disulfide bond.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family. Kallikrein subfamily.
CC       {ECO:0000255|PROSITE-ProRule:PRU00274}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M11566; AAA41467.1; -; mRNA.
DR   EMBL; BC061771; AAH61771.1; -; mRNA.
DR   PIR; D23863; D23863.
DR   RefSeq; NP_786935.1; NM_175759.2.
DR   AlphaFoldDB; P07647; -.
DR   SMR; P07647; -.
DR   STRING; 10116.ENSRNOP00000025723; -.
DR   MEROPS; S01.407; -.
DR   GlyGen; P07647; 1 site.
DR   PaxDb; P07647; -.
DR   PRIDE; P07647; -.
DR   Ensembl; ENSRNOT00000025723; ENSRNOP00000025723; ENSRNOG00000067884.
DR   GeneID; 292868; -.
DR   KEGG; rno:292868; -.
DR   UCSC; RGD:727805; rat.
DR   CTD; 292868; -.
DR   RGD; 727805; Klks3.
DR   eggNOG; KOG3627; Eukaryota.
DR   GeneTree; ENSGT01020000230389; -.
DR   InParanoid; P07647; -.
DR   OrthoDB; 1076876at2759; -.
DR   PhylomeDB; P07647; -.
DR   TreeFam; TF331065; -.
DR   BRENDA; 3.4.21.B40; 5301.
DR   Reactome; R-RNO-1592389; Activation of Matrix Metalloproteinases.
DR   Reactome; R-RNO-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
DR   PRO; PR:P07647; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000032857; Expressed in pancreas and 19 other tissues.
DR   ExpressionAtlas; P07647; baseline and differential.
DR   Genevisible; P07647; RN.
DR   GO; GO:0030141; C:secretory granule; IBA:GO_Central.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0045907; P:positive regulation of vasoconstriction; IDA:RGD.
DR   GO; GO:0003073; P:regulation of systemic arterial blood pressure; IBA:GO_Central.
DR   GO; GO:0031638; P:zymogen activation; IBA:GO_Central.
DR   CDD; cd00190; Tryp_SPc; 1.
DR   Gene3D; 2.40.10.10; -; 2.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR018114; TRYPSIN_HIS.
DR   InterPro; IPR033116; TRYPSIN_SER.
DR   Pfam; PF00089; Trypsin; 1.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF50494; SSF50494; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Glycoprotein; Hydrolase;
KW   Protease; Reference proteome; Serine protease; Signal; Zymogen.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000305"
FT   PROPEP          19..24
FT                   /note="Activation peptide"
FT                   /evidence="ECO:0000269|PubMed:1315752,
FT                   ECO:0000269|PubMed:1536657, ECO:0000269|PubMed:1900513"
FT                   /id="PRO_0000028009"
FT   CHAIN           25..259
FT                   /note="Submandibular glandular kallikrein-9"
FT                   /id="PRO_0000028010"
FT   CHAIN           25..111
FT                   /note="Submandibular glandular kallikrein-9 light chain"
FT                   /id="PRO_0000028011"
FT   CHAIN           112..259
FT                   /note="Submandibular glandular kallikrein-9 heavy chain"
FT                   /id="PRO_0000028012"
FT   DOMAIN          25..256
FT                   /note="Peptidase S1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT   ACT_SITE        63
FT                   /note="Charge relay system"
FT   ACT_SITE        118
FT                   /note="Charge relay system"
FT   ACT_SITE        211
FT                   /note="Charge relay system"
FT   CARBOHYD        106
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000305"
FT   DISULFID        31..171
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT   DISULFID        48..64
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT   DISULFID        150..217
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT   DISULFID        182..196
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT   DISULFID        207..232
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
SQ   SEQUENCE   259 AA;  28368 MW;  D167E8518BEC0791 CRC64;
     MWFLILFLAL SLGQIDAAPP GQSRVVGGYN CETNSQPWQV AVIGTTFCGG VLIDPSWVIT
     AAHCYSKNYR VLLGRNNLVK DEPFAQRRLV SQSFQHPDYI PVFMRNHTRQ RAYDHNNDLM
     LLHLSKPADI TGGVKVIDLP TEEPKVGSIC LASGWGMTNP SEMKLSHDLQ CVNIHLLSNE
     KCIETYKNIE TDVTLCAGEM DGGKDTCTGD SGGPLICDGV LQGLTSGGAT PCAKPKTPAI
     YAKLIKFTSW IKKVMKENP
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024