ID   KLP1_CHLRE              Reviewed;         776 AA.
AC   P46870;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Kinesin-like protein KLP1;
GN   Name=KLP1;
OS   Chlamydomonas reinhardtii (Chlamydomonas smithii).
OC   Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC   CS clade; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX   NCBI_TaxID=3055;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=21gr / CC-1690;
RX   PubMed=8207060; DOI=10.1083/jcb.125.6.1313;
RA   Bernstein M., Beech P.L., Katz S.G., Rosenbaum J.L.;
RT   "A new kinesin-like protein (Klp1) localized to a single microtubule of the
RT   Chlamydomonas flagellum.";
RL   J. Cell Biol. 125:1313-1326(1994).
CC   -!- FUNCTION: May play a role in rotation or twisting of the central pair
CC       microtubules of the flagella axoneme.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme.
CC       Note=Bound to the central pair microtubule C2 or to projections that
CC       are attached to C2.
CC   -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC       superfamily. Kinesin family. {ECO:0000255|PROSITE-ProRule:PRU00283}.
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DR   EMBL; X78589; CAA55326.1; -; mRNA.
DR   PIR; A53953; A53953.
DR   AlphaFoldDB; P46870; -.
DR   SMR; P46870; -.
DR   STRING; 3055.EDP06592; -.
DR   PRIDE; P46870; -.
DR   ProMEX; P46870; -.
DR   eggNOG; KOG4280; Eukaryota.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0031514; C:motile cilium; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR   GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR   GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR   Gene3D; 3.40.850.10; -; 1.
DR   InterPro; IPR027640; Kinesin-like_fam.
DR   InterPro; IPR019821; Kinesin_motor_CS.
DR   InterPro; IPR001752; Kinesin_motor_dom.
DR   InterPro; IPR036961; Kinesin_motor_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR24115; PTHR24115; 1.
DR   Pfam; PF00225; Kinesin; 1.
DR   PRINTS; PR00380; KINESINHEAVY.
DR   SMART; SM00129; KISc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR   PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Cell projection; Cilium; Cilium biogenesis/degradation;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Flagellum; Microtubule;
KW   Motor protein; Nucleotide-binding.
FT   CHAIN           1..776
FT                   /note="Kinesin-like protein KLP1"
FT                   /id="PRO_0000125456"
FT   DOMAIN          5..335
FT                   /note="Kinesin motor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
FT   REGION          441..535
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          658..776
FT                   /note="Globular"
FT                   /evidence="ECO:0000255"
FT   COILED          348..371
FT                   /evidence="ECO:0000255"
FT   COILED          579..657
FT                   /evidence="ECO:0000255"
FT   BINDING         91..98
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
SQ   SEQUENCE   776 AA;  83020 MW;  48646509DE8AA71D CRC64;
     MVKQAVKVFV RTRPTATSGS GLKLGPDGQS VSVNVPKDLS AGPVNNQQEQ FSFKFDGVLE
     NVSQEAAYTT LAHEVVDSLM AGYHGTIFAY GQTGAGKTFT MSGGGTAYAH RGLIPRAIHH
     VFREVDMRAD KMYRVHVSYL EIYNEQLYDL LGDTPGTSDA LAVLEDSNSN TYVRGLTLVP
     VRSEEEALAQ FFLGEQGRTT AGHVLNAESS RSHTVFTIHV EMRTSDAASE RAVLSKLNLV
     DLAGSERTKK TGVTGQTLKE AQFINRSLSF LEQTVNALSR KDTYVPFRQT KLTAVLRDAL
     GGNCKTVMVA NIWAEPSHNE ETLSTLRFAS RVRTLTTDLA LNESNDPALL LRRYERQIKE
     LKAELAMRDT LSGKGRVSYD DLTDDELREL HATCRRFLHG EAEPEDLPAD SMKRVRETFK
     ALRAVHVAIK ADMATQMATL RRATEEGSGA AARGGDSAGP SGVGDVDLRA TGGFTVGHAP
     LDARPPVRSE LGSPGAGASG AEALGEPRSP GGGLHAQASS HTDAGSNWGD AGPLSSPGGT
     RLAGIFGVSG DRNAVFRRYK VDVGEGRELA ASLKAASIAL ADTKASIRSL GASVNDAKQR
     IDELSSALAL RRGATPAGGD GEVLDSEAYA LMQELKSAKS RYRTDFDSLK SAREELEPQI
     QAVAVARAGL LEAFDRWAAA QSDTTLKRMA TAGRAMSGIA PGEEDEMDAG EQFERMQIAR
     ISERDPDSLA FHTALKRTGA AVSRPATVAT GGNAKAAAMA TRKMEHTQAV NRGLAR