KLP3_CAEEL
ID KLP3_CAEEL Reviewed; 598 AA.
AC P45962; Q7JMP3; Q7JMP4;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Kinesin-like protein klp-3;
GN Name=klp-3; ORFNames=T09A5.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- INTERACTION:
CC P45962; Q9U3B7: hsb-1; NbExp=2; IntAct=EBI-311892, EBI-311898;
CC P45962; G5EC32: sorb-1; NbExp=3; IntAct=EBI-311892, EBI-325337;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=a;
CC IsoId=P45962-1; Sequence=Displayed;
CC Name=b;
CC IsoId=P45962-2; Sequence=VSP_020787, VSP_020788;
CC Name=c;
CC IsoId=P45962-3; Sequence=VSP_020786, VSP_020787, VSP_020788;
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000255|PROSITE-ProRule:PRU00283}.
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DR EMBL; Z36753; CAA85331.1; -; Genomic_DNA.
DR EMBL; Z36753; CAF31495.1; -; Genomic_DNA.
DR EMBL; Z36753; CAF31496.1; -; Genomic_DNA.
DR PIR; T24717; T24717.
DR RefSeq; NP_001022332.1; NM_001027161.2. [P45962-1]
DR RefSeq; NP_001022333.1; NM_001027162.2.
DR RefSeq; NP_001022334.1; NM_001027163.2.
DR AlphaFoldDB; P45962; -.
DR SMR; P45962; -.
DR BioGRID; 56196; 9.
DR DIP; DIP-24659N; -.
DR IntAct; P45962; 6.
DR STRING; 6239.T09A5.2a; -.
DR EPD; P45962; -.
DR PaxDb; P45962; -.
DR PeptideAtlas; P45962; -.
DR PRIDE; P45962; -.
DR EnsemblMetazoa; T09A5.2a.1; T09A5.2a.1; WBGene00002216. [P45962-1]
DR EnsemblMetazoa; T09A5.2b.1; T09A5.2b.1; WBGene00002216.
DR EnsemblMetazoa; T09A5.2c.1; T09A5.2c.1; WBGene00002216.
DR GeneID; 191697; -.
DR KEGG; cel:CELE_T09A5.2; -.
DR UCSC; T09A5.2a; c. elegans. [P45962-1]
DR CTD; 191697; -.
DR WormBase; T09A5.2a; CE01083; WBGene00002216; klp-3. [P45962-1]
DR WormBase; T09A5.2b; CE36407; WBGene00002216; klp-3. [P45962-2]
DR WormBase; T09A5.2c; CE36408; WBGene00002216; klp-3. [P45962-3]
DR eggNOG; KOG0239; Eukaryota.
DR GeneTree; ENSGT00940000154022; -.
DR HOGENOM; CLU_001485_12_4_1; -.
DR InParanoid; P45962; -.
DR OMA; MDNGVVH; -.
DR OrthoDB; 364605at2759; -.
DR PhylomeDB; P45962; -.
DR SignaLink; P45962; -.
DR PRO; PR:P45962; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00002216; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR ExpressionAtlas; P45962; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0015630; C:microtubule cytoskeleton; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007059; P:chromosome segregation; IMP:WormBase.
DR GO; GO:0051304; P:chromosome separation; IMP:WormBase.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR GO; GO:0007017; P:microtubule-based process; IBA:GO_Central.
DR Gene3D; 3.40.850.10; -; 1.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; ATP-binding; Coiled coil; Cytoplasm; Cytoskeleton;
KW Microtubule; Motor protein; Nucleotide-binding; Reference proteome.
FT CHAIN 1..598
FT /note="Kinesin-like protein klp-3"
FT /id="PRO_0000125457"
FT DOMAIN 245..565
FT /note="Kinesin motor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
FT REGION 133..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 569..598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 19..66
FT /evidence="ECO:0000255"
FT COILED 89..118
FT /evidence="ECO:0000255"
FT COILED 170..248
FT /evidence="ECO:0000255"
FT COMPBIAS 133..148
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 328..335
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
FT VAR_SEQ 66..82
FT /note="Missing (in isoform c)"
FT /evidence="ECO:0000305"
FT /id="VSP_020786"
FT VAR_SEQ 135
FT /note="S -> R (in isoform b and isoform c)"
FT /evidence="ECO:0000305"
FT /id="VSP_020787"
FT VAR_SEQ 136..598
FT /note="Missing (in isoform b and isoform c)"
FT /evidence="ECO:0000305"
FT /id="VSP_020788"
SQ SEQUENCE 598 AA; 67323 MW; FBF971AD52905690 CRC64;
MDSHVGEVDI FQQCKYIHEV ELVNMKLQMR ILETHIETKD RLLRNLEDII DEQESRIANM
EDFIQGRATS YTNRSNMLKG ISVLSLDFGN LSEENLRLKN ALSQMQKVAR VNELLETDED
YESDMTSNED RFALSRDSSC SVPRSVSPQP TGDVIKPYPQ MVQSMREEGH WKKLQRCAEE
LKTEKDELKR LALDTKDAFN VCMAEMRMML TSKTTDFFRV LIERYKAEME KRKQLHNQLV
ELNGNIRVFY RIRPQLASET DNQKPVVVID EMDNGVVHVS NTTGTRKTSA GADKVIPTDF
SQDQIFNEVS PIITSCIDGY NVCIFAYGHT GSGKTYTMDG PVTMPGINQR AIMQLFETAK
ERTGDIKYDI KVAMMEIYNE KIRDLLNTSN TNLAIRQTEE GRSSIPGLEE VSVNSAEEVT
ETLARGRKNK AVAATEANIE SSRSHVIVRV LVSATNLITK ATTVGRLNLV DLAGSERVSQ
TNATGQLLKE AQAINKSLSE LGNVVLALRQ NQKHIPFRNC QLTRILEDSL NGDSKTLVIV
HLSPDAKSLN ESISSVNFAE KIGQVFTKSG TMKREPTRRS MTGISSGQRR EIPASPRK
