KLP68_DROPS
ID KLP68_DROPS Reviewed; 797 AA.
AC Q29DY1;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Kinesin-like protein Klp68D;
GN Name=Klp68D {ECO:0000250|UniProtKB:P46867}; ORFNames=GA20244;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1] {ECO:0000312|EMBL:EAL30282.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: Plus-end directed microtubule motor that may be used for
CC anterograde axonal transport and could conceivably move cargos in fly
CC neurons different than those moved by kinesin heavy chain or other
CC plus-end directed motors. {ECO:0000250|UniProtKB:P46867}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. Kinesin II subfamily.
CC {ECO:0000255|PROSITE-ProRule:PRU00283}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAL30282.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; CH379070; EAL30282.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_001352782.1; XM_001352746.3.
DR RefSeq; XP_015043852.1; XM_015188366.1.
DR AlphaFoldDB; Q29DY1; -.
DR SMR; Q29DY1; -.
DR STRING; 7237.FBpp0286237; -.
DR PRIDE; Q29DY1; -.
DR EnsemblMetazoa; FBtr0287799; FBpp0286237; FBgn0080239.
DR EnsemblMetazoa; FBtr0377361; FBpp0338404; FBgn0080239.
DR GeneID; 4812180; -.
DR KEGG; dpo:Dpse_GA20244; -.
DR eggNOG; KOG4280; Eukaryota.
DR HOGENOM; CLU_001485_22_4_1; -.
DR InParanoid; Q29DY1; -.
DR OMA; CKHDHNQ; -.
DR PhylomeDB; Q29DY1; -.
DR Proteomes; UP000001819; Chromosome X.
DR Bgee; FBgn0080239; Expressed in insect adult head and 2 other tissues.
DR GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005875; C:microtubule associated complex; ISS:UniProtKB.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003774; F:cytoskeletal motor activity; ISS:UniProtKB.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0008089; P:anterograde axonal transport; IEA:EnsemblMetazoa.
DR GO; GO:0030951; P:establishment or maintenance of microtubule cytoskeleton polarity; IEA:EnsemblMetazoa.
DR GO; GO:0007018; P:microtubule-based movement; ISS:UniProtKB.
DR GO; GO:0007608; P:sensory perception of smell; IEA:EnsemblMetazoa.
DR Gene3D; 3.40.850.10; -; 1.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24115; PTHR24115; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Coiled coil; Cytoplasm; Cytoskeleton; Microtubule;
KW Motor protein; Nucleotide-binding; Reference proteome.
FT CHAIN 1..797
FT /note="Kinesin-like protein Klp68D"
FT /id="PRO_0000270579"
FT DOMAIN 19..344
FT /note="Kinesin motor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
FT REGION 371..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 610..656
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 722..797
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 350..384
FT /evidence="ECO:0000255"
FT COILED 432..580
FT /evidence="ECO:0000255"
FT COMPBIAS 420..434
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 435..450
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 744..765
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 106..113
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 797 AA; 89225 MW; 37D6B08E3F6FA23C CRC64;
MSAKSRRPGT ASSQTPNECV QVVVRCRPMS NRERSEGSPE VVNVYPNRGV VELQNVVDAN
KEQRKVFTYD AAYDASASQT TLYHEVVFPL VSSVLEGFNG CIFAYGQTGT GKTFTMEGVR
GNDDLMGIIP RTFEQIWLHI NRTENFQFLV DVSYLEIYME ELRDLLKPNS KHLEVRERGS
GVYVPNLHAI NCKSVDDMIR VMKVGNKNRT VGFTNMNEHS SRSHAIFMIK IEMCDTETNT
IKVGKLNLID LAGSERQSKT GASAERLKEA SKINLALSSL GNVISALAES SPHVPYRDSK
LTRLLQDSLG GNSKTIMIAN IGPSNYNYNE TLTTLRYASR AKSIQNQPIK NEDPQDAKLK
EYQEEIERLK RLIAPQQQQR SEKQGTIKKQ RVKKPKKEPI SQELIGSALQ ASSADLQVDE
DRDSDGDGAE SESDKENEAE VAKSNEELER ERVENAKLAA KLAELEGQLV RGGKNLLDTY
SERQIELEKK LVEIAERKKR EIEIQQQLEL QEETTLEIRE RNVSLEQEVE LKKRKLSKCY
AKYLALQQEL NDCKHDHNQD LRELEMAQNE LVKELKRQLL IIDNFVPIEV KQRLYTQAKY
DEEQEEWKFS SFPLPLPPSG GDGRQGYRRP VSHPQRRRPT SEHALQEAKS NAPSSLRFKS
ENIVSYELEM PCRTTQEYRT PKVSASLQAV LAQAMQTGGD DIDIVDSHTN SLRSRLENII
NANSSSNGGP GSGAGPLAAN TAGSGVGSMP NVRNIKSSRG LPSAGTALDS NRRPPTGRIP
AKKPASAYPK ARGLVNK
