KLP8_SCHPO
ID KLP8_SCHPO Reviewed; 511 AA.
AC Q9UTL2;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Kinesin-like protein 8;
GN Name=klp8; ORFNames=SPAC144.14;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-278; SER-279; SER-284 AND
RP SER-456, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000255|PROSITE-ProRule:PRU00283}.
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DR EMBL; CU329670; CAB59694.1; -; Genomic_DNA.
DR PIR; T37681; T37681.
DR RefSeq; NP_594675.1; NM_001020104.2.
DR AlphaFoldDB; Q9UTL2; -.
DR SMR; Q9UTL2; -.
DR BioGRID; 279295; 6.
DR DIP; DIP-59763N; -.
DR IntAct; Q9UTL2; 1.
DR STRING; 4896.SPAC144.14.1; -.
DR iPTMnet; Q9UTL2; -.
DR SwissPalm; Q9UTL2; -.
DR MaxQB; Q9UTL2; -.
DR PaxDb; Q9UTL2; -.
DR PRIDE; Q9UTL2; -.
DR EnsemblFungi; SPAC144.14.1; SPAC144.14.1:pep; SPAC144.14.
DR GeneID; 2542849; -.
DR KEGG; spo:SPAC144.14; -.
DR PomBase; SPAC144.14; klp8.
DR VEuPathDB; FungiDB:SPAC144.14; -.
DR eggNOG; KOG0241; Eukaryota.
DR HOGENOM; CLU_001485_2_3_1; -.
DR InParanoid; Q9UTL2; -.
DR OMA; CISPTDY; -.
DR PhylomeDB; Q9UTL2; -.
DR Reactome; R-SPO-9696273; RND1 GTPase cycle.
DR PRO; PR:Q9UTL2; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0032153; C:cell division site; HDA:PomBase.
DR GO; GO:0051286; C:cell tip; HDA:PomBase.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:0005871; C:kinesin complex; IBA:GO_Central.
DR GO; GO:0071341; C:medial cortical node; IDA:PomBase.
DR GO; GO:0032178; C:medial membrane band; IDA:PomBase.
DR GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR GO; GO:0044732; C:mitotic spindle pole body; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0003777; F:microtubule motor activity; ISM:PomBase.
DR GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR Gene3D; 3.40.850.10; -; 1.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24115; PTHR24115; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 1: Evidence at protein level;
KW ATP-binding; Coiled coil; Cytoplasm; Cytoskeleton; Microtubule;
KW Motor protein; Nucleotide-binding; Phosphoprotein; Reference proteome.
FT CHAIN 1..511
FT /note="Kinesin-like protein 8"
FT /id="PRO_0000125390"
FT DOMAIN 5..356
FT /note="Kinesin motor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
FT COILED 373..489
FT /evidence="ECO:0000255"
FT BINDING 107..114
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
FT MOD_RES 278
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 279
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 284
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 456
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 511 AA; 57254 MW; F6ED1C9ABBA28CE1 CRC64;
MSTANVRVIV RVRPKSLREL SKSAEDLLSV DSHNKTVTIT PPKHGLKHSR HKNRVNGPRT
FAFDECFAPS APESKNLSGQ EDVYESTGPL LVKSILEGFN SCFITYGQKG TGKTYSVVGL
RGQPGIIPHI SESIFEEIDK LKKKSPNTTI TVSISLAEII EETPYDLLQP NVNSSHTPGE
TVFVQKDSLT GYHLHGLSEF EVGSAQEIDA FLRLAAKNIR TELSDISGVR KGHSVFSLVV
QQRIIDPKTR HSLKKASRLQ IIDLASFSKG SQRNESISSF ESSSNNKSLS VLNRVIAALT
SKKNDVLIPY KDSVLTTLLQ DALGGNCRTI MLTCVSPCDF DDTFSALRYS EAARRIKNIS
NINCKEAYST NNEGELDDIL TTLESDREQL RRHEEHSQKL LKFIEEIRND YEERIHALES
QNSALKAHLR LAVDAYLNPL EFNFDDKNVK LKEFGSPNIA YKQELNSFQG ELSSLFKDLK
LVKSQLHDYP KPEVSDIDMD MESLRHDSLL D
