ID   KLPS_LYCER              Reviewed;          14 AA.
AC   P58396;
DT   13-DEC-2001, integrated into UniProtKB/Swiss-Prot.
DT   13-DEC-2001, sequence version 1.
DT   26-FEB-2020, entry version 37.
DE   RecName: Full=Kinin-like peptide-S;
DE   Flags: Fragment;
OS   Lycosa erythrognatha (Wolf spider) (Scaptocosa raptoria).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Araneomorphae; Entelegynae; Lycosoidea; Lycosidae; Lycosa.
OX   NCBI_TaxID=332789;
RN   [1]
RP   PROTEIN SEQUENCE, AND FUNCTION.
RC   TISSUE=Venom;
RX   PubMed=9604280; DOI=10.1016/s0041-0101(97)00059-7;
RA   Ferreira L.A.F., Lucas S.M., Alves E.W., Hermann V.V., Reichl A.P.,
RA   Habermehl G., Zingali R.B.;
RT   "Isolation, characterization and biological properties of two kinin-like
RT   peptides (peptide-S and peptide-R) from Scaptocosa raptoria venom.";
RL   Toxicon 36:31-39(1998).
CC   -!- FUNCTION: Has kinin-like biological properties. Causes contraction of
CC       isolated guinea pig ileum and relaxation of rat duodenum. Has a number
CC       of hypotensive properties: decreases arterial blood pressure and
CC       increases capillary permeability. Induces edema when injected into
CC       hindpaw of rat. May target bradykinin receptors (BDKRB). Does not lyse
CC       unfibrinolysed blood. {ECO:0000269|PubMed:9604280}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- MISCELLANEOUS: The molecular weight of about 4 kDa suggests that the
CC       mature peptide comprises about 36 amino acid residues.
CC   -!- SIMILARITY: Belongs to the bradykinin-related peptide family.
CC       {ECO:0000305}.
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DR   ArachnoServer; AS000005; Kinin-1-Lycosa erythognatha.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0042311; P:vasodilation; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Bradykinin receptor impairing toxin; Direct protein sequencing;
KW   G-protein coupled receptor impairing toxin; Secreted; Toxin; Vasoactive;
KW   Vasodilator.
FT   CHAIN           1..>14
FT                   /note="Kinin-like peptide-S"
FT                   /id="PRO_0000084309"
FT   NON_TER         14
SQ   SEQUENCE   14 AA;  1511 MW;  E811E2E5D2EE27CA CRC64;
     RLVLEVXASV EADV