KLRA2_MOUSE
ID KLRA2_MOUSE Reviewed; 288 AA.
AC Q60660;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 121.
DE RecName: Full=Killer cell lectin-like receptor 2;
DE AltName: Full=Lymphocyte antigen 49b;
DE Short=Ly-49b;
DE AltName: Full=T-cell surface glycoprotein Ly-49B;
GN Name=Klra2; Synonyms=Ly49-b, Ly49b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6 X CBA; TISSUE=Lung;
RX PubMed=1869832;
RA Wong S., Freeman J.D., Kelleher C., Mager D., Takei F.;
RT "Ly-49 multigene family. New members of a superfamily of type II membrane
RT proteins with lectin-like domains.";
RL J. Immunol. 147:1417-1423(1991).
CC -!- FUNCTION: Receptor on natural killer (NK) cells for class I MHC.
CC -!- SUBUNIT: Homodimer; disulfide-linked.
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
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DR EMBL; U10304; AAA19052.1; -; mRNA.
DR CCDS; CCDS20603.1; -.
DR PIR; I49058; I49058.
DR AlphaFoldDB; Q60660; -.
DR SMR; Q60660; -.
DR GlyGen; Q60660; 4 sites.
DR iPTMnet; Q60660; -.
DR PhosphoSitePlus; Q60660; -.
DR MaxQB; Q60660; -.
DR PRIDE; Q60660; -.
DR ProteomicsDB; 263634; -.
DR MGI; MGI:101906; Klra2.
DR InParanoid; Q60660; -.
DR PhylomeDB; Q60660; -.
DR PRO; PR:Q60660; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q60660; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:MGI.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd03593; CLECT_NK_receptors_like; 1.
DR Gene3D; 3.10.100.10; -; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR013600; Ly49_N.
DR InterPro; IPR033992; NKR-like_CTLD.
DR Pfam; PF00059; Lectin_C; 1.
DR Pfam; PF08391; Ly49; 1.
DR SMART; SM00034; CLECT; 1.
DR SUPFAM; SSF56436; SSF56436; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE 2: Evidence at transcript level;
KW Cell adhesion; Disulfide bond; Glycoprotein; Lectin; Membrane; Receptor;
KW Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1..288
FT /note="Killer cell lectin-like receptor 2"
FT /id="PRO_0000046680"
FT TOPO_DOM 1..45
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 46..66
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 67..288
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT DOMAIN 144..263
FT /note="C-type lectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT CARBOHYD 94
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 105
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 114
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 177
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 151..156
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 169..257
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 173..259
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 238..251
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
SQ SEQUENCE 288 AA; 33607 MW; B3A410A32DF8E82F CRC64;
MSEQEVTYTT LRFHKSSGLQ NPVRPEETQR PRDVGHRECS VPWKFIVIVL GILCFLLLLT
VAVLVIHIFR DGQEKHEQEK TLNNLRQEYQ VMKNDSSLME EMLRNKSSEC KALNDSLHYL
NREQNRCLRK TKIVLDCSQN KGKQVEGYWF CCGMKCYYFI MDDKKWNGCK QICQDYNLTL
LKTNDEDELK FLKSQLQRNT YWISLTHHKS KEESQQIGDR PSKLDSAARN SVPNRQKCAY
LSSFSTEEDD CARTHGCICE KRLNKFPIPG SCAKGRTQSA LQRDEDES
