KLRA5_MOUSE
ID KLRA5_MOUSE Reviewed; 266 AA.
AC Q60652;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Killer cell lectin-like receptor 5;
DE AltName: Full=Lymphocyte antigen 49e;
DE Short=Ly-49e;
DE AltName: Full=T-cell surface glycoprotein Ly-49E;
GN Name=Klra5; Synonyms=Ly-49e, Ly49-e, Ly49e;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J; TISSUE=Spleen;
RX PubMed=8027540;
RA Smith H.R.C., Karlhofer F.M., Yokoyama W.M.;
RT "Ly-49 multigene family expressed by IL-2-activated NK cells.";
RL J. Immunol. 153:1068-1079(1994).
RN [2]
RP SUBUNIT, AND TISSUE SPECIFICITY.
RX PubMed=11254682; DOI=10.4049/jimmunol.166.7.4302;
RA Van Beneden K., Stevenaert F., De Creus A., Debacker V., De Boever J.,
RA Plum J., Leclercq G.;
RT "Expression of Ly49E and CD94/NKG2 on fetal and adult NK cells.";
RL J. Immunol. 166:4302-4311(2001).
CC -!- FUNCTION: Receptor on natural killer (NK) cells for class I MHC.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000269|PubMed:11254682}.
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
CC -!- TISSUE SPECIFICITY: Mostly expressed in NK cells, but also observed on
CC NK T and memory T-cells. {ECO:0000269|PubMed:11254682}.
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DR EMBL; U10091; AAA50219.1; -; mRNA.
DR CCDS; CCDS20596.1; -.
DR PIR; I49050; I49050.
DR RefSeq; NP_032489.1; NM_008463.2.
DR AlphaFoldDB; Q60652; -.
DR SMR; Q60652; -.
DR STRING; 10090.ENSMUSP00000112795; -.
DR GlyGen; Q60652; 3 sites.
DR PaxDb; Q60652; -.
DR PRIDE; Q60652; -.
DR DNASU; 16636; -.
DR Ensembl; ENSMUST00000014683; ENSMUSP00000014683; ENSMUSG00000030173.
DR Ensembl; ENSMUST00000118060; ENSMUSP00000112795; ENSMUSG00000030173.
DR GeneID; 16636; -.
DR KEGG; mmu:16636; -.
DR UCSC; uc009egx.2; mouse.
DR CTD; 16636; -.
DR MGI; MGI:101903; Klra5.
DR VEuPathDB; HostDB:ENSMUSG00000030173; -.
DR eggNOG; KOG4297; Eukaryota.
DR GeneTree; ENSGT00390000008117; -.
DR HOGENOM; CLU_049894_1_0_1; -.
DR InParanoid; Q60652; -.
DR OMA; QKMAYSS; -.
DR OrthoDB; 1180904at2759; -.
DR PhylomeDB; Q60652; -.
DR TreeFam; TF336674; -.
DR BioGRID-ORCS; 16636; 0 hits in 70 CRISPR screens.
DR ChiTaRS; Klra5; mouse.
DR PRO; PR:Q60652; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q60652; protein.
DR Bgee; ENSMUSG00000030173; Expressed in granulocyte and 24 other tissues.
DR ExpressionAtlas; Q60652; baseline and differential.
DR Genevisible; Q60652; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:MGI.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd03593; CLECT_NK_receptors_like; 1.
DR Gene3D; 3.10.100.10; -; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR013600; Ly49_N.
DR InterPro; IPR033992; NKR-like_CTLD.
DR Pfam; PF00059; Lectin_C; 1.
DR Pfam; PF08391; Ly49; 1.
DR SMART; SM00034; CLECT; 1.
DR SUPFAM; SSF56436; SSF56436; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE 1: Evidence at protein level;
KW Cell adhesion; Disulfide bond; Glycoprotein; Lectin; Membrane; Receptor;
KW Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1..266
FT /note="Killer cell lectin-like receptor 5"
FT /id="PRO_0000046683"
FT TOPO_DOM 1..44
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 45..66
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 67..266
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT DOMAIN 143..261
FT /note="C-type lectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT CARBOHYD 87
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 104
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 250
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 149..154
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 167..255
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 171..257
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 236..249
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
SQ SEQUENCE 266 AA; 30843 MW; B8B07F221875049C CRC64;
MSEPEVTYST VRLHKSSGLQ RLVSHEEIQG PGEAGYRKCS VPWQLTVRSL GIFCFLLLVT
VAVLAVKIFQ YSQHKQEIHE TLNHNHNCSN MQSDIKLKEE MLRNKSIDCS PGEELLESLN
REQNRWYSET KTDLDSSQDT GTGVKHWFCY GTKCFYFIMS KNTWSGCKQT CQHYSLPLVK
IEDEDELKFL QFQVISDSYW IGLSYDKKKK QWAWIDNGPS KLDMKTRKMN FKPGGCIFLS
KTRLEDTNCN NSYFCICGKK LDHFPG
