KLRA6_MOUSE
ID KLRA6_MOUSE Reviewed; 266 AA.
AC Q60653;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Killer cell lectin-like receptor 6;
DE AltName: Full=Lymphocyte antigen 49f;
DE Short=Ly-49f;
DE AltName: Full=T-cell surface glycoprotein Ly-49F;
GN Name=Klra6; Synonyms=Ly-49f, Ly49-f, Ly49F;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J; TISSUE=Spleen;
RX PubMed=8027540;
RA Smith H.R.C., Karlhofer F.M., Yokoyama W.M.;
RT "Ly-49 multigene family expressed by IL-2-activated NK cells.";
RL J. Immunol. 153:1068-1079(1994).
CC -!- FUNCTION: Receptor on natural killer (NK) cells for class I MHC.
CC -!- SUBUNIT: Homodimer; disulfide-linked.
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
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DR EMBL; U10092; AAA50220.1; -; mRNA.
DR CCDS; CCDS20597.1; -.
DR PIR; I49051; I49051.
DR RefSeq; NP_032490.1; NM_008464.2.
DR RefSeq; XP_006505712.1; XM_006505649.1.
DR RefSeq; XP_006505713.1; XM_006505650.3.
DR AlphaFoldDB; Q60653; -.
DR SMR; Q60653; -.
DR STRING; 10090.ENSMUSP00000073700; -.
DR GlyGen; Q60653; 2 sites.
DR PaxDb; Q60653; -.
DR PRIDE; Q60653; -.
DR DNASU; 16637; -.
DR Ensembl; ENSMUST00000074056; ENSMUSP00000073700; ENSMUSG00000061769.
DR GeneID; 16637; -.
DR KEGG; mmu:16637; -.
DR UCSC; uc009ehe.1; mouse.
DR CTD; 16637; -.
DR MGI; MGI:101902; Klra6.
DR VEuPathDB; HostDB:ENSMUSG00000061769; -.
DR eggNOG; KOG4297; Eukaryota.
DR GeneTree; ENSGT00390000008117; -.
DR HOGENOM; CLU_049894_1_0_1; -.
DR InParanoid; Q60653; -.
DR OMA; CVFLSKR; -.
DR OrthoDB; 969006at2759; -.
DR PhylomeDB; Q60653; -.
DR TreeFam; TF336674; -.
DR BioGRID-ORCS; 16637; 0 hits in 51 CRISPR screens.
DR PRO; PR:Q60653; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q60653; protein.
DR Bgee; ENSMUSG00000061769; Expressed in soleus muscle and 18 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:MGI.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd03593; CLECT_NK_receptors_like; 1.
DR Gene3D; 3.10.100.10; -; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR013600; Ly49_N.
DR InterPro; IPR033992; NKR-like_CTLD.
DR Pfam; PF00059; Lectin_C; 1.
DR Pfam; PF08391; Ly49; 1.
DR SMART; SM00034; CLECT; 1.
DR SUPFAM; SSF56436; SSF56436; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE 2: Evidence at transcript level;
KW Cell adhesion; Disulfide bond; Glycoprotein; Lectin; Membrane; Receptor;
KW Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1..266
FT /note="Killer cell lectin-like receptor 6"
FT /id="PRO_0000046684"
FT TOPO_DOM 1..44
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 45..66
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 67..266
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT DOMAIN 143..261
FT /note="C-type lectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT CARBOHYD 87
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 104
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 149..154
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 167..255
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 171..257
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 236..249
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
SQ SEQUENCE 266 AA; 31269 MW; AD180AA9C762F1F6 CRC64;
MSEPEVTYST VRLHKSSRLQ KLVRHEETQG PREAGYRKCS VCWQLIVKAL GILCFLLLIT
VAVLAVKIFQ YGQHNQEIHE TLNYHHNCSN MQSDFNLKEE MLTNRSIDSR PGNELLESLN
REQNRGYSET KTDLDSSQDT GTGVKYWFCY RTKCYYFIMN KNTWSGCKQN CQHYSLPLVK
IDDENELKFL QFQVIPDSYW IGLSYDKEKK EWAWIDNGQS KLDMKIRKMN FKPGGCVFLS
KRRLEDTNCK NSHYCICGKK LDKFPH
