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KLRD1_PANTR
ID   KLRD1_PANTR             Reviewed;         179 AA.
AC   Q9MZ41;
DT   15-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=Natural killer cells antigen CD94;
DE   AltName: Full=Killer cell lectin-like receptor subfamily D member 1;
DE   AltName: Full=NK cell receptor;
DE   AltName: CD_antigen=CD94;
GN   Name=KLRD1; Synonyms=CD94;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX   PubMed=10894168; DOI=10.1016/s1074-7613(00)80219-8;
RA   Khakoo S.I., Rajalingam R., Shum B.P., Weidenbach K., Flodin L., Muir D.G.,
RA   Canavez F., Cooper S.L., Valiante N.M., Lanier L.L., Parham P.;
RT   "Rapid evolution of NK cell receptor systems demonstrated by comparison of
RT   chimpanzees and humans.";
RL   Immunity 12:687-698(2000).
RN   [2]
RP   ALTERNATIVE SPLICING.
RX   PubMed=11751968; DOI=10.4049/jimmunol.168.1.240;
RA   Shum B.P., Flodin L.R., Muir D.G., Rajalingam R., Khakoo S.I., Cleland S.,
RA   Guethlein L.A., Uhrberg M., Parham P.;
RT   "Conservation and variation in human and common chimpanzee CD94 and NKG2
RT   genes.";
RL   J. Immunol. 168:240-252(2002).
CC   -!- FUNCTION: Immune receptor involved in self-nonself discrimination. In
CC       complex with KLRC1 or KLRC2 on cytotoxic and regulatory lymphocyte
CC       subsets, recognizes non-classical major histocompatibility (MHC) class
CC       Ib molecule MHC-E loaded with self-peptides derived from the signal
CC       sequence of classical MHC class Ia and non-classical MHC class Ib
CC       molecules. Enables cytotoxic cells to monitor the expression of MHC
CC       class I molecules in healthy cells and to tolerate self. Primarily
CC       functions as a ligand binding subunit as it lacks the capacity to
CC       signal. {ECO:0000250|UniProtKB:Q13241}.
CC   -!- FUNCTION: KLRD1-KLRC1 acts as an immune inhibitory receptor. Key
CC       inhibitory receptor on natural killer (NK) cells that regulates their
CC       activation and effector functions. Dominantly counteracts T cell
CC       receptor signaling on a subset of memory/effector CD8-positive T cells
CC       as part of an antigen-driven response to avoid autoimmunity. On
CC       intraepithelial CD8-positive gamma-delta regulatory T cells triggers
CC       TGFB1 secretion, which in turn limits the cytotoxic programming of
CC       intraepithelial CD8-positive alpha-beta T cells, distinguishing
CC       harmless from pathogenic antigens. In MHC-E-rich tumor
CC       microenvironment, acts as an immune inhibitory checkpoint and may
CC       contribute to progressive loss of effector functions of NK cells and
CC       tumor-specific T cells, a state known as cell exhaustion. Upon MHC-E-
CC       peptide binding, transmits intracellular signals through KLRC1
CC       immunoreceptor tyrosine-based inhibition motifs (ITIMs) by recruiting
CC       INPP5D/SHIP-1 and INPPL1/SHIP-2 tyrosine phosphatases to ITIMs, and
CC       ultimately opposing signals transmitted by activating receptors through
CC       dephosphorylation of proximal signaling molecules.
CC       {ECO:0000250|UniProtKB:Q13241}.
CC   -!- FUNCTION: KLRD1-KLRC2 acts as an immune activating receptor. On
CC       cytotoxic lymphocyte subsets recognizes MHC-E loaded with signal
CC       sequence-derived peptides from non-classical MHC class Ib MHC-G
CC       molecules, likely playing a role in the generation and effector
CC       functions of adaptive NK cells and in maternal-fetal tolerance during
CC       pregnancy. Regulates the effector functions of terminally
CC       differentiated cytotoxic lymphocyte subsets, and in particular may play
CC       a role in adaptive NK cell response to viral infection. Upon MHC-E-
CC       peptide binding, transmits intracellular signals via the adapter
CC       protein TYROBP/DAP12, triggering the phosphorylation of proximal
CC       signaling molecules and cell activation.
CC       {ECO:0000250|UniProtKB:Q13241}.
CC   -!- SUBUNIT: Can form disulfide-bonded heterodimer with NKG2 family members
CC       KLRC1 and KLRC2. KLRD1-KLRC1 heterodimer interacts with peptide-bound
CC       MHC-E-B2M heterotrimeric complex. KLRD1 plays a prominent role in
CC       directly interacting with MHC-E. KLRD1-KLRC1 interacts with much higher
CC       affinity with peptide-bound MHC-E-B2M than KLRD1-KLRC2. Interacts with
CC       the adapter protein TYROBP/DAP12; this interaction is required for cell
CC       surface expression and cell activation. {ECO:0000250|UniProtKB:Q13241}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q13241};
CC       Single-pass type II membrane protein {ECO:0000255}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC         Comment=Additional isoforms seem to exist.;
CC       Name=1; Synonyms=CD94-A;
CC         IsoId=Q9MZ41-1; Sequence=Displayed;
CC       Name=2; Synonyms=CD94-B;
CC         IsoId=Q9MZ41-2; Sequence=VSP_003056;
CC   -!- TISSUE SPECIFICITY: Natural killer cells.
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DR   EMBL; AF259054; AAF86964.1; -; mRNA.
DR   RefSeq; NP_001009062.1; NM_001009062.1. [Q9MZ41-1]
DR   RefSeq; XP_009423053.1; XM_009424778.2. [Q9MZ41-1]
DR   RefSeq; XP_016778010.1; XM_016922521.1. [Q9MZ41-1]
DR   AlphaFoldDB; Q9MZ41; -.
DR   SMR; Q9MZ41; -.
DR   STRING; 9598.ENSPTRP00000057110; -.
DR   PaxDb; Q9MZ41; -.
DR   Ensembl; ENSPTRT00000065546; ENSPTRP00000057110; ENSPTRG00000004671. [Q9MZ41-1]
DR   GeneID; 450156; -.
DR   KEGG; ptr:450156; -.
DR   CTD; 3824; -.
DR   eggNOG; KOG4297; Eukaryota.
DR   GeneTree; ENSGT00940000160107; -.
DR   HOGENOM; CLU_049894_9_3_1; -.
DR   InParanoid; Q9MZ41; -.
DR   OMA; GWIGYQC; -.
DR   OrthoDB; 1389571at2759; -.
DR   TreeFam; TF336674; -.
DR   Proteomes; UP000002277; Chromosome 12.
DR   Bgee; ENSPTRG00000004671; Expressed in lung and 20 other tissues.
DR   GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR   GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   GO; GO:0062082; F:HLA-E specific inhibitory MHC class Ib receptor activity; IEA:Ensembl.
DR   GO; GO:0023024; F:MHC class I protein complex binding; IEA:Ensembl.
DR   GO; GO:0023030; F:MHC class Ib protein binding, via antigen binding groove; IEA:Ensembl.
DR   GO; GO:1990405; F:protein antigen binding; IEA:Ensembl.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   GO; GO:0002228; P:natural killer cell mediated immunity; IEA:Ensembl.
DR   GO; GO:0045953; P:negative regulation of natural killer cell mediated cytotoxicity; ISS:UniProtKB.
DR   GO; GO:0001915; P:negative regulation of T cell mediated cytotoxicity; ISS:UniProtKB.
DR   GO; GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IBA:GO_Central.
DR   GO; GO:0002223; P:stimulatory C-type lectin receptor signaling pathway; ISS:UniProtKB.
DR   CDD; cd03593; CLECT_NK_receptors_like; 1.
DR   Gene3D; 3.10.100.10; -; 1.
DR   InterPro; IPR001304; C-type_lectin-like.
DR   InterPro; IPR016186; C-type_lectin-like/link_sf.
DR   InterPro; IPR016187; CTDL_fold.
DR   InterPro; IPR033992; NKR-like_CTLD.
DR   Pfam; PF00059; Lectin_C; 1.
DR   SMART; SM00034; CLECT; 1.
DR   SUPFAM; SSF56436; SSF56436; 1.
DR   PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE   2: Evidence at transcript level;
KW   Adaptive immunity; Alternative splicing; Cell membrane; Disulfide bond;
KW   Glycoprotein; Immunity; Innate immunity; Lectin; Membrane; Receptor;
KW   Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
FT   CHAIN           1..179
FT                   /note="Natural killer cells antigen CD94"
FT                   /id="PRO_0000046589"
FT   TOPO_DOM        1..10
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        11..31
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        32..179
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          68..175
FT                   /note="C-type lectin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT   CARBOHYD        83
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        132
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        58..70
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT   DISULFID        59
FT                   /note="Interchain (with C-116 in KLRC1/NGK2A)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT   DISULFID        61..72
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT   DISULFID        89..174
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT   DISULFID        152..166
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT   VAR_SEQ         105
FT                   /note="L -> LQ (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_003056"
SQ   SEQUENCE   179 AA;  20493 MW;  7244D99E8D9587E7 CRC64;
     MAVFKTTLWR LISGTLGIIC LSLMATLGIL LKNSFTKLSI EPAFTPGPNI ELQKDSDCCS
     CQEKWVGYRC NCYFISSEQK TWNESRHLCA SQKSSLLQLQ NTDELDFMSS SQQFYWIGLS
     YSEEHTAWLW ENGSALSQYL FPSFETFNPK NCIAYNPNGN ALDESCEDKN RYICKQQLI
 
 
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