ID   KLRF1_MACFA             Reviewed;         231 AA.
AC   Q8MI05;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Killer cell lectin-like receptor subfamily F member 1;
DE            Short=Lectin-like receptor F1;
DE   AltName: Full=Activating coreceptor NKp80;
GN   Name=KLRF1;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Natural killer cell;
RA   Biassoni R.;
RT   "Macaca fascicularis NK cell and receptors.";
RL   Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the natural killer (NK)-mediated cytolysis of
CC       PHA-induced lymphoblasts. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II
CC       membrane protein {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJ426430; CAD19994.1; -; mRNA.
DR   RefSeq; NP_001272253.1; NM_001285324.1.
DR   AlphaFoldDB; Q8MI05; -.
DR   SMR; Q8MI05; -.
DR   STRING; 9541.XP_005570147.1; -.
DR   PRIDE; Q8MI05; -.
DR   Ensembl; ENSMFAT00000045749; ENSMFAP00000011005; ENSMFAG00000012038.
DR   GeneID; 102141941; -.
DR   CTD; 51348; -.
DR   VEuPathDB; HostDB:ENSMFAG00000012038; -.
DR   eggNOG; KOG4297; Eukaryota.
DR   GeneTree; ENSGT00940000163227; -.
DR   Proteomes; UP000233100; Chromosome 11.
DR   Bgee; ENSMFAG00000012038; Expressed in spleen and 8 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   CDD; cd03593; CLECT_NK_receptors_like; 1.
DR   Gene3D; 3.10.100.10; -; 1.
DR   InterPro; IPR001304; C-type_lectin-like.
DR   InterPro; IPR016186; C-type_lectin-like/link_sf.
DR   InterPro; IPR016187; CTDL_fold.
DR   InterPro; IPR033992; NKR-like_CTLD.
DR   Pfam; PF00059; Lectin_C; 1.
DR   SMART; SM00034; CLECT; 1.
DR   SUPFAM; SSF56436; SSF56436; 1.
DR   PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Lectin; Membrane; Receptor;
KW   Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
FT   CHAIN           1..231
FT                   /note="Killer cell lectin-like receptor subfamily F member
FT                   1"
FT                   /id="PRO_0000046592"
FT   TOPO_DOM        1..38
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        39..59
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        60..231
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          121..230
FT                   /note="C-type lectin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT   CARBOHYD        77
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        91
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        96
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        176
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        142..229
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT   DISULFID        208..221
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
SQ   SEQUENCE   231 AA;  26710 MW;  403C79CA6883C1E7 CRC64;
     MQDEERYMTL NVQSKKRTST QTTQLTFKDY SVVLHWYKIL LGISGTLNGI LALALISLIL
     LVSQGVLLKC QKGSHSNTTE HEDIGDLKMN NGTRRNTSNK DLCVSRSADQ TVLCQSEWLK
     YRGKCYWFSN EMKSWSDSYV YCLERKSHLL IIQDELEMAF IQKNLRQSNY VWMGLNFTSL
     KMTWTWVDGS PLDPKIFFIK GPAKENSCAA IKESKIYSET CSSVFKWICQ Y