KLRG1_RAT
ID KLRG1_RAT Reviewed; 188 AA.
AC Q64335;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Killer cell lectin-like receptor subfamily G member 1;
DE AltName: Full=Mast cell function-associated antigen;
GN Name=Klrg1; Synonyms=Mafa;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT, TISSUE SPECIFICITY, AND
RP PHOSPHORYLATION.
RX PubMed=7568140; DOI=10.1073/pnas.92.20.9397;
RA Guthmann M.D., Tal M., Pecht I.;
RT "A secretion inhibitory signal transduction molecule on mast cells is
RT another C-type lectin.";
RL Proc. Natl. Acad. Sci. U.S.A. 92:9397-9401(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RC STRAIN=Sprague-Dawley; TISSUE=Testis;
RX PubMed=9120279;
RA Bocek P. Jr., Guthmann M.D., Pecht I.;
RT "Analysis of the genes encoding the mast cell function-associated antigen
RT and its alternatively spliced transcripts.";
RL J. Immunol. 158:3235-3243(1997).
CC -!- FUNCTION: Plays an inhibitory role on natural killer (NK) cells and T-
CC cell functions upon binding to their non-MHC ligands. May mediate
CC missing self recognition by binding to a highly conserved site on
CC classical cadherins, enabling it to monitor expression of E-
CC cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Forms a monomer and homodimer; disulfide-linked. Interacts
CC (via ITIM motif) with PTPN11 and INPP5D (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type II
CC membrane protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in lung mast cells.
CC {ECO:0000269|PubMed:7568140, ECO:0000269|PubMed:9120279}.
CC -!- DOMAIN: Contains 1 copy of a cytoplasmic motif that is referred to as
CC the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is
CC involved in modulation of cellular responses. Upon phosphorylation of
CC ITIM motif KLRG1 associates with the two phosphatases, PTPN11 and
CC INPP5D.
CC -!- PTM: Phosphorylated in response to monoclonal antibody G63 binding and
CC antigenic stimulation. {ECO:0000269|PubMed:7568140}.
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DR EMBL; X79812; CAA56208.1; -; mRNA.
DR EMBL; X97191; CAA65829.1; -; Genomic_DNA.
DR EMBL; X97192; CAA65829.1; JOINED; Genomic_DNA.
DR EMBL; X97193; CAA65829.1; JOINED; Genomic_DNA.
DR EMBL; X97194; CAA65829.1; JOINED; Genomic_DNA.
DR EMBL; X97195; CAA65829.1; JOINED; Genomic_DNA.
DR PIR; I59421; I59421.
DR RefSeq; NP_113837.1; NM_031649.2.
DR AlphaFoldDB; Q64335; -.
DR SMR; Q64335; -.
DR STRING; 10116.ENSRNOP00000020094; -.
DR GlyGen; Q64335; 2 sites.
DR PaxDb; Q64335; -.
DR GeneID; 58975; -.
DR KEGG; rno:58975; -.
DR UCSC; RGD:61978; rat.
DR CTD; 10219; -.
DR RGD; 61978; Klrg1.
DR VEuPathDB; HostDB:ENSRNOG00000014918; -.
DR eggNOG; KOG4297; Eukaryota.
DR HOGENOM; CLU_049894_8_3_1; -.
DR InParanoid; Q64335; -.
DR OMA; SCPDFWM; -.
DR OrthoDB; 1299162at2759; -.
DR PhylomeDB; Q64335; -.
DR TreeFam; TF336674; -.
DR PRO; PR:Q64335; -.
DR Proteomes; UP000002494; Chromosome 4.
DR Bgee; ENSRNOG00000014918; Expressed in liver and 5 other tissues.
DR Genevisible; Q64335; RN.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030246; F:carbohydrate binding; IDA:RGD.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR CDD; cd03593; CLECT_NK_receptors_like; 1.
DR Gene3D; 3.10.100.10; -; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR042190; KLRG1.
DR InterPro; IPR033992; NKR-like_CTLD.
DR PANTHER; PTHR47648; PTHR47648; 1.
DR Pfam; PF00059; Lectin_C; 1.
DR SMART; SM00034; CLECT; 1.
DR SUPFAM; SSF56436; SSF56436; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; Glycoprotein; Immunity; Innate immunity;
KW Lectin; Membrane; Phosphoprotein; Receptor; Reference proteome;
KW Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1..188
FT /note="Killer cell lectin-like receptor subfamily G member
FT 1"
FT /id="PRO_0000331258"
FT TOPO_DOM 1..34
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 35..55
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 56..188
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT DOMAIN 82..184
FT /note="C-type lectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT MOTIF 5..10
FT /note="ITIM motif"
FT CARBOHYD 82
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 97
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 75..86
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 103..183
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 162..175
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
SQ SEQUENCE 188 AA; 21356 MW; 2CC8032D4D020B15 CRC64;
MADNSIYSTL ELPAAPRVQD DSRWKVKAVL HRPCVSYLVM VALGLLTVIL MSLLLYQRTL
CCGSKGFMCS QCSRCPNLWM RNGSHCYYFS MEKRDWNSSL KFCADKGSHL LTFPDNQGVN
LFQEYVGEDF YWIGLRDIDG WRWEDGPALS LSILSNSVVQ KCGTIHRCGL HASSCEVALQ
WICEKVLP
