KLRG2_HUMAN
ID KLRG2_HUMAN Reviewed; 409 AA.
AC A4D1S0; Q2NL79; Q6ZTV6;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 3.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Killer cell lectin-like receptor subfamily G member 2;
DE AltName: Full=C-type lectin domain family 15 member B;
GN Name=KLRG2; Synonyms=CLEC15B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Thymus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT THR-152.
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A4D1S0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A4D1S0-2; Sequence=VSP_030779, VSP_030780;
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DR EMBL; AK126174; BAC86473.1; -; mRNA.
DR EMBL; AC005531; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH236950; EAL24036.1; -; Genomic_DNA.
DR EMBL; BC104963; AAI04964.1; -; mRNA.
DR EMBL; BC104965; AAI04966.1; -; mRNA.
DR EMBL; BC110858; AAI10859.1; -; mRNA.
DR CCDS; CCDS5854.1; -. [A4D1S0-1]
DR RefSeq; NP_940910.1; NM_198508.2. [A4D1S0-1]
DR AlphaFoldDB; A4D1S0; -.
DR SMR; A4D1S0; -.
DR BioGRID; 131397; 108.
DR IntAct; A4D1S0; 50.
DR MINT; A4D1S0; -.
DR STRING; 9606.ENSP00000339356; -.
DR iPTMnet; A4D1S0; -.
DR PhosphoSitePlus; A4D1S0; -.
DR BioMuta; KLRG2; -.
DR EPD; A4D1S0; -.
DR jPOST; A4D1S0; -.
DR MassIVE; A4D1S0; -.
DR MaxQB; A4D1S0; -.
DR PaxDb; A4D1S0; -.
DR PeptideAtlas; A4D1S0; -.
DR PRIDE; A4D1S0; -.
DR ProteomicsDB; 627; -. [A4D1S0-1]
DR ProteomicsDB; 628; -. [A4D1S0-2]
DR Antibodypedia; 2744; 76 antibodies from 17 providers.
DR DNASU; 346689; -.
DR Ensembl; ENST00000340940.5; ENSP00000339356.4; ENSG00000188883.5. [A4D1S0-1]
DR Ensembl; ENST00000393039.2; ENSP00000376759.2; ENSG00000188883.5. [A4D1S0-2]
DR GeneID; 346689; -.
DR KEGG; hsa:346689; -.
DR MANE-Select; ENST00000340940.5; ENSP00000339356.4; NM_198508.4; NP_940910.1.
DR UCSC; uc003vvb.4; human. [A4D1S0-1]
DR CTD; 346689; -.
DR DisGeNET; 346689; -.
DR GeneCards; KLRG2; -.
DR HGNC; HGNC:24778; KLRG2.
DR HPA; ENSG00000188883; Tissue enhanced (esophagus, salivary gland, thyroid gland).
DR neXtProt; NX_A4D1S0; -.
DR OpenTargets; ENSG00000188883; -.
DR PharmGKB; PA162393624; -.
DR VEuPathDB; HostDB:ENSG00000188883; -.
DR eggNOG; KOG4297; Eukaryota.
DR GeneTree; ENSGT00940000162997; -.
DR HOGENOM; CLU_049894_8_6_1; -.
DR InParanoid; A4D1S0; -.
DR OMA; GLPMYVK; -.
DR OrthoDB; 1201127at2759; -.
DR PhylomeDB; A4D1S0; -.
DR TreeFam; TF351467; -.
DR PathwayCommons; A4D1S0; -.
DR SignaLink; A4D1S0; -.
DR BioGRID-ORCS; 346689; 15 hits in 1076 CRISPR screens.
DR ChiTaRS; KLRG2; human.
DR GenomeRNAi; 346689; -.
DR Pharos; A4D1S0; Tdark.
DR PRO; PR:A4D1S0; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; A4D1S0; protein.
DR Bgee; ENSG00000188883; Expressed in sural nerve and 47 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR CDD; cd03593; CLECT_NK_receptors_like; 1.
DR Gene3D; 3.10.100.10; -; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR043318; KLRG2.
DR InterPro; IPR033992; NKR-like_CTLD.
DR PANTHER; PTHR47606; PTHR47606; 1.
DR Pfam; PF00059; Lectin_C; 1.
DR SMART; SM00034; CLECT; 1.
DR SUPFAM; SSF56436; SSF56436; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Disulfide bond; Lectin; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..409
FT /note="Killer cell lectin-like receptor subfamily G member
FT 2"
FT /id="PRO_0000316792"
FT TRANSMEM 263..283
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 300..405
FT /note="C-type lectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT REGION 1..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 193..216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 158
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3UM83"
FT DISULFID 321..404
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 383..396
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT VAR_SEQ 253..312
FT /note="GLPMYVKSLYWALAFMAVLLAVSGVVIVVLASRAGARCQQCPPGWVLSEEHC
FT YYFSAEAQ -> DSLRTARTIWISTVGPWRKARWWLQTAALQDPGSVPRGPSDLGSAWS
FT SACQADAAPPTGEAS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_030779"
FT VAR_SEQ 313..409
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_030780"
FT VARIANT 152
FT /note="K -> T (in dbSNP:rs1860150)"
FT /evidence="ECO:0000269|PubMed:12690205"
FT /id="VAR_038396"
FT VARIANT 339
FT /note="G -> A (in dbSNP:rs17160911)"
FT /id="VAR_038397"
FT CONFLICT 109
FT /note="A -> V (in Ref. 3; EAL24036)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 409 AA; 42851 MW; E4AD53ED44E1240E CRC64;
MEESWEAAPG GQAGAELPME PVGSLVPTLE QPQVPAKVRQ PEGPESSPSP AGAVEKAAGA
GLEPSSKKKP PSPRPGSPRV PPLSLGYGVC PEPPSPGPAL VKLPRNGEAP GAEPAPSAWA
PMELQVDVRV KPVGAAGGSS TPSPRPSTRF LKVPVPESPA FSRHADPAHQ LLLRAPSQGG
TWGRRSPLAA ARTESGCDAE GRASPAEGSA GSPGSPTCCR CKELGLEKED AALLPRAGLD
GDEKLPRAVT LTGLPMYVKS LYWALAFMAV LLAVSGVVIV VLASRAGARC QQCPPGWVLS
EEHCYYFSAE AQAWEASQAF CSAYHATLPL LSHTQDFLGR YPVSRHSWVG AWRGPQGWHW
IDEAPLPPQL LPEDGEDNLD INCGALEEGT LVAANCSTPR PWVCAKGTQ
