KLRI1_MOUSE
ID KLRI1_MOUSE Reviewed; 248 AA.
AC B2KG20; Q5DT35;
DT 25-OCT-2017, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Killer cell lectin-like receptor subfamily I member 1 {ECO:0000303|PubMed:15650876};
GN Name=Klri1 {ECO:0000303|PubMed:15650876};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000312|Proteomes:UP000000589};
RN [1] {ECO:0000312|EMBL:AAR00559.1}
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:AAR00559.1};
RX PubMed=15650876; DOI=10.1007/s00251-004-0759-x;
RA Saether P.C., Westgaard I.H., Flornes L.M., Hoelsbrekken S.E., Ryan J.C.,
RA Fossum S., Dissen E.;
RT "Molecular cloning of KLRI1 and KLRI2, a novel pair of lectin-like natural
RT killer-cell receptors with opposing signalling motifs.";
RL Immunogenetics 56:833-839(2005).
RN [2] {ECO:0000312|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0000305}
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=18713988; DOI=10.4049/jimmunol.181.5.3177;
RA Saether P.C., Westgaard I.H., Hoelsbrekken S.E., Benjamin J., Lanier L.L.,
RA Fossum S., Dissen E.;
RT "KLRE/I1 and KLRE/I2: a novel pair of heterodimeric receptors that
RT inversely regulate NK cell cytotoxicity.";
RL J. Immunol. 181:3177-3182(2008).
CC -!- FUNCTION: Lectin-like receptor for natural killer (NK) cells.
CC Heterodimer formation with KLRE1 mediates inhibition of NK cell
CC cytolytic activity. {ECO:0000269|PubMed:18713988}.
CC -!- SUBUNIT: Heterodimer with KLRE1. Interacts with PTPN6.
CC {ECO:0000250|UniProtKB:Q5DT39}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18713988};
CC Single-pass type II membrane protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed in natural killer (NK) cells.
CC {ECO:0000269|PubMed:15650876}.
CC -!- DOMAIN: Contains 2 copies of a cytoplasmic motif that is referred to as
CC the immunoreceptor tyrosine-based inhibitor motif (ITIM). The
CC phosphorylated ITIM motif can bind the SH2 domain of several SH2-
CC containing phosphatases leading to down-regulation of cell activation.
CC {ECO:0000250|UniProtKB:P27812}.
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DR EMBL; AY324874; AAR00559.1; -; mRNA.
DR EMBL; AC171002; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS20593.1; -.
DR RefSeq; NP_001012538.2; NM_001012520.2.
DR AlphaFoldDB; B2KG20; -.
DR SMR; B2KG20; -.
DR STRING; 10090.ENSMUSP00000085362; -.
DR GlyGen; B2KG20; 3 sites.
DR PaxDb; B2KG20; -.
DR PRIDE; B2KG20; -.
DR Ensembl; ENSMUST00000088046; ENSMUSP00000085362; ENSMUSG00000067610.
DR GeneID; 503550; -.
DR KEGG; mmu:503550; -.
DR UCSC; uc009egq.1; mouse.
DR CTD; 503550; -.
DR MGI; MGI:3530275; Klri1.
DR VEuPathDB; HostDB:ENSMUSG00000067610; -.
DR eggNOG; KOG4297; Eukaryota.
DR GeneTree; ENSGT00940000164228; -.
DR HOGENOM; CLU_049894_9_2_1; -.
DR InParanoid; B2KG20; -.
DR OMA; CAKLNSH; -.
DR OrthoDB; 1105684at2759; -.
DR PhylomeDB; B2KG20; -.
DR TreeFam; TF336674; -.
DR BioGRID-ORCS; 503550; 4 hits in 72 CRISPR screens.
DR PRO; PR:B2KG20; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; B2KG20; protein.
DR Bgee; ENSMUSG00000067610; Expressed in spleen and 18 other tissues.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; ISO:MGI.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
DR GO; GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IBA:GO_Central.
DR GO; GO:0002223; P:stimulatory C-type lectin receptor signaling pathway; IBA:GO_Central.
DR CDD; cd03593; CLECT_NK_receptors_like; 1.
DR Gene3D; 3.10.100.10; -; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR033992; NKR-like_CTLD.
DR Pfam; PF00059; Lectin_C; 1.
DR SMART; SM00034; CLECT; 1.
DR SUPFAM; SSF56436; SSF56436; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; Lectin; Membrane;
KW Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1..248
FT /note="Killer cell lectin-like receptor subfamily I member
FT 1"
FT /id="PRO_0000442199"
FT TOPO_DOM 1..80
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 81..101
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 102..248
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT DOMAIN 139..245
FT /note="C-type lectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT MOTIF 16..21
FT /note="ITIM motif 1"
FT /evidence="ECO:0000250|UniProtKB:P27812"
FT MOTIF 47..52
FT /note="ITIM motif 2"
FT /evidence="ECO:0000250|UniProtKB:P27812"
FT CARBOHYD 197
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 214
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 220
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT DISULFID 132..145
FT /evidence="ECO:0000250|UniProtKB:Q13241"
FT DISULFID 161..244
FT /evidence="ECO:0000250|UniProtKB:Q13241"
FT DISULFID 223..236
FT /evidence="ECO:0000250|UniProtKB:Q13241"
FT CONFLICT 72
FT /note="Q -> H (in Ref. 1; AAR00559)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 248 AA; 28642 MW; 6A82D2A10CACE120 CRC64;
MLHSKRREYT ANNQDVTYTE LKTCKSPWKH RIPTVKQSPV VLCEEQLKYG ELTFHRTPQP
QPRKQAMGRK RQGPKSTVWR VVTGMLGALC VVLMTTTGIL LPKLFSSQEE QCRKTSLHPL
RCPKDDASCD LCSSDWIAFG NNFYCVFKEN TKTWAESQSA CEELNSHLVI IDSKAEVENL
LLFEMDGWIL HKMDGTNSSW LWRNDIKIQN TLTNDSEKKN HSCHYLRGNL FMPDECSAKK
SYICEFNI
