ID   KM11_LEITR              Reviewed;          92 AA.
AC   O21436;
DT   19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Kinetoplastid membrane protein 11;
DE            Short=KMP-11;
GN   Name=KMP-11;
OS   Leishmania tropica.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5666 {ECO:0000312|EMBL:CAA03902.1};
RN   [1] {ECO:0000312|EMBL:CAA03902.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10668791; DOI=10.1089/104454900314708;
RA   Thomas M.C., Garcia-Perez J.L., Alonso C., Lopez M.C.;
RT   "Molecular characterization of KMP11 from Trypanosoma cruzi: a
RT   cytoskeleton-associated protein regulated at the translational level.";
RL   DNA Cell Biol. 19:47-57(2000).
CC   -!- FUNCTION: May be involved in the regulation of the cytoskeleton through
CC       interaction with the subpellicular microtubules. May be involved in
CC       parasite mobility and attachment to the surface of the host cell.
CC       Behaves as a strong immunogen during infection (By similarity).
CC       {ECO:0000250|UniProtKB:Q9U6Z1}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250|UniProtKB:Q25297}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton
CC       {ECO:0000250}. Note=Associated with microtubules. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the KMP-11 family. {ECO:0000305}.
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DR   EMBL; AJ000078; CAA03902.1; -; mRNA.
DR   AlphaFoldDB; O21436; -.
DR   SMR; O21436; -.
DR   VEuPathDB; TriTrypDB:LTRL590_350027600; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0015630; C:microtubule cytoskeleton; ISS:UniProtKB.
DR   GO; GO:0007010; P:cytoskeleton organization; ISS:UniProtKB.
DR   GO; GO:0006952; P:defense response; IEA:InterPro.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:InterPro.
DR   InterPro; IPR004132; KMP11.
DR   Pfam; PF03037; KMP11; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Cytoskeleton; Microtubule.
FT   CHAIN           1..92
FT                   /note="Kinetoplastid membrane protein 11"
FT                   /id="PRO_0000205714"
SQ   SEQUENCE   92 AA;  11235 MW;  C73700CC91F368D7 CRC64;
     MATTYEEFSA KLDRLDEEFN RKMQEQNAKF FADKPDESTL SPEMKEHYEK FERMIKEHTE
     KFNKKMHEHS EHFKQKFAEL LEQQKAAQYP SK