ID   KM11_TRYBR              Reviewed;          92 AA.
AC   P69301; Q26773;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 38.
DE   RecName: Full=Kinetoplastid membrane protein 11;
DE            Short=KMP-11;
GN   Name=KMP-11;
OS   Trypanosoma brucei rhodesiense.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=31286;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 32-45.
RX   PubMed=8892307; DOI=10.1016/0166-6851(96)02678-3;
RA   Stebeck C.E., Baron G.S., Beecroft R.P., Pearson T.W.;
RT   "Molecular characterization of the kinetoplastid membrane protein-11 from
RT   African trypanosomes.";
RL   Mol. Biochem. Parasitol. 81:81-88(1996).
RN   [2]
RP   SUBCELLULAR LOCATION.
RX   PubMed=7630374; DOI=10.1016/0166-6851(95)00022-s;
RA   Stebeck C.E., Beecroft R.P., Singh B.N., Jardim A., Olafson R.W.,
RA   Tuckey C., Prenevost K.D., Pearson T.W.;
RT   "Kinetoplastid membrane protein-11 (KMP-11) is differentially expressed
RT   during the life cycle of African trypanosomes and is found in a wide
RT   variety of kinetoplastid parasites.";
RL   Mol. Biochem. Parasitol. 71:1-13(1995).
CC   -!- FUNCTION: May be involved in the regulation of the cytoskeleton through
CC       interaction with the subpellicular microtubules. May be involved in
CC       parasite mobility and attachment to the surface of the host cell.
CC       Behaves as a strong immunogen during infection (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000269|PubMed:7630374}. Note=Associated with microtubules.
CC   -!- SIMILARITY: Belongs to the KMP-11 family. {ECO:0000305}.
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DR   EMBL; X96439; CAA65305.1; -; Genomic_DNA.
DR   AlphaFoldDB; P69301; -.
DR   SMR; P69301; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0015630; C:microtubule cytoskeleton; ISS:UniProtKB.
DR   GO; GO:0007010; P:cytoskeleton organization; ISS:UniProtKB.
DR   GO; GO:0006952; P:defense response; IEA:InterPro.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:InterPro.
DR   InterPro; IPR004132; KMP11.
DR   Pfam; PF03037; KMP11; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Cytoskeleton; Direct protein sequencing; Microtubule.
FT   CHAIN           1..92
FT                   /note="Kinetoplastid membrane protein 11"
FT                   /id="PRO_0000205716"
SQ   SEQUENCE   92 AA;  11077 MW;  B50328C81A770E4C CRC64;
     MATTYEEFAA KLDRLDAEFA KKMEEQNKRF FADKPDEATL SPEMKEHYEK FEKMIQEHTD
     KFNKKMREHS EHFKAKFAEL LEQQKNAQFP GK