ID   KM11_TRYCR              Reviewed;          92 AA.
AC   Q9U6Z1; O21435; Q9U6Z0;
DT   19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 2.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Kinetoplastid membrane protein 11;
DE            Short=KMP-11;
GN   Name=KMP-11; Synonyms=KMP11;
OS   Trypanosoma cruzi.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX   NCBI_TaxID=5693 {ECO:0000312|EMBL:CAA03901.1};
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE, SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RC   STRAIN=Tulahuen, and Y;
RX   PubMed=10668791; DOI=10.1089/104454900314708;
RA   Thomas M.C., Garcia-Perez J.L., Alonso C., Lopez M.C.;
RT   "Molecular characterization of KMP11 from Trypanosoma cruzi: a
RT   cytoskeleton-associated protein regulated at the translational level.";
RL   DNA Cell Biol. 19:47-57(2000).
RN   [2] {ECO:0000305}
RP   FUNCTION.
RX   PubMed=11298135; DOI=10.1046/j.1365-2249.2001.01478.x;
RA   Thomas M.C., Longobardo M.V., Carmelo E., Maranon C., Planelles L.,
RA   Patarroyo M.E., Alonso C., Lopez M.C.;
RT   "Mapping of the antigenic determinants of the T. cruzi kinetoplastid
RT   membrane protein-11. Identification of a linear epitope specifically
RT   recognized by human Chagasic sera.";
RL   Clin. Exp. Immunol. 123:465-471(2001).
CC   -!- FUNCTION: May be involved in the regulation of the cytoskeleton through
CC       interaction with the subpellicular microtubules. May be involved in
CC       parasite mobility and attachment to the surface of the host cell.
CC       Behaves as a strong immunogen during infection.
CC       {ECO:0000269|PubMed:11298135, ECO:0000303|PubMed:10668791}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250|UniProtKB:Q25297}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000269|PubMed:10668791}. Note=Associated with microtubules.
CC   -!- DEVELOPMENTAL STAGE: Abundantly expressed in amastigotes and
CC       trypomastigotes. In epimastigotes, KMP-11 is expressed at a high level
CC       during the logarithmic growth phase but is down-regulated during the
CC       stationary phase of growth. {ECO:0000269|PubMed:10668791}.
CC   -!- MISCELLANEOUS: There are four copies of the KMP-11 gene in T.cruzi.
CC       {ECO:0000269|PubMed:10668791}.
CC   -!- SIMILARITY: Belongs to the KMP-11 family. {ECO:0000305}.
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DR   EMBL; AJ000077; CAA03901.1; -; mRNA.
DR   EMBL; AF167435; AAF04809.1; -; Genomic_DNA.
DR   EMBL; AF167436; AAF04810.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9U6Z1; -.
DR   SMR; Q9U6Z1; -.
DR   VEuPathDB; TriTrypDB:BCY84_13933; -.
DR   VEuPathDB; TriTrypDB:C3747_1g318c; -.
DR   VEuPathDB; TriTrypDB:C3747_1g319c; -.
DR   VEuPathDB; TriTrypDB:C3747_268g105c; -.
DR   VEuPathDB; TriTrypDB:C4B63_2g166c; -.
DR   VEuPathDB; TriTrypDB:TcBrA4_0063250; -.
DR   VEuPathDB; TriTrypDB:TcCLB.508413.76; -.
DR   VEuPathDB; TriTrypDB:TcCLB.510755.89; -.
DR   VEuPathDB; TriTrypDB:TCDM_03377; -.
DR   VEuPathDB; TriTrypDB:TcG_02054; -.
DR   VEuPathDB; TriTrypDB:TcYC6_0068230; -.
DR   OMA; HSEHFKH; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0015630; C:microtubule cytoskeleton; IDA:UniProtKB.
DR   GO; GO:0060285; P:cilium-dependent cell motility; NAS:UniProtKB.
DR   GO; GO:0007010; P:cytoskeleton organization; IDA:UniProtKB.
DR   GO; GO:0006952; P:defense response; IEA:InterPro.
DR   GO; GO:0044409; P:entry into host; NAS:UniProtKB.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:InterPro.
DR   InterPro; IPR004132; KMP11.
DR   Pfam; PF03037; KMP11; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Microtubule.
FT   CHAIN           1..92
FT                   /note="Kinetoplastid membrane protein 11"
FT                   /id="PRO_0000205717"
FT   CONFLICT        92
FT                   /note="Missing (in Ref. 1; AAF04809)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   92 AA;  11011 MW;  341CDD0E21D3EFB1 CRC64;
     MATTLEEFSA KLDRLDAEFA KKMEEQNKKF FADKPDESTL SPEMKEHYEK FEKMIQEHTD
     KFNKKMHEHS EHFKAKFAEL LEQQKNAQFP GK