KMCP1_RAT
ID KMCP1_RAT Reviewed; 291 AA.
AC Q5PQM9;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Kidney mitochondrial carrier protein 1;
DE AltName: Full=Solute carrier family 25 member 30;
GN Name=Slc25a30; Synonyms=Kmcp1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Probable transporter. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with VDAC1. {ECO:0000250|UniProtKB:Q5SVS4}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; BC087106; AAH87106.1; -; mRNA.
DR RefSeq; NP_001013205.1; NM_001013187.1.
DR RefSeq; XP_008769095.1; XM_008770873.2.
DR AlphaFoldDB; Q5PQM9; -.
DR SMR; Q5PQM9; -.
DR STRING; 10116.ENSRNOP00000001389; -.
DR jPOST; Q5PQM9; -.
DR Ensembl; ENSRNOT00000104191; ENSRNOP00000097957; ENSRNOG00000001052.
DR GeneID; 361074; -.
DR KEGG; rno:361074; -.
DR UCSC; RGD:1359702; rat.
DR CTD; 253512; -.
DR RGD; 1359702; Slc25a30.
DR GeneTree; ENSGT00940000158961; -.
DR InParanoid; Q5PQM9; -.
DR OrthoDB; 1126848at2759; -.
DR PRO; PR:Q5PQM9; -.
DR Proteomes; UP000002494; Chromosome 15.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; ISO:RGD.
DR GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
DR GO; GO:0015140; F:malate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015131; F:oxaloacetate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015141; F:succinate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015116; F:sulfate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015117; F:thiosulfate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0071423; P:malate transmembrane transport; IBA:GO_Central.
DR GO; GO:0015729; P:oxaloacetate transport; IBA:GO_Central.
DR GO; GO:0035435; P:phosphate ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0071422; P:succinate transmembrane transport; IBA:GO_Central.
DR GO; GO:0008272; P:sulfate transport; IBA:GO_Central.
DR GO; GO:0015709; P:thiosulfate transport; IBA:GO_Central.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Acetylation; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q5SVS4"
FT CHAIN 2..291
FT /note="Kidney mitochondrial carrier protein 1"
FT /id="PRO_0000288919"
FT TRANSMEM 9..26
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..89
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..124
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..183
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..224
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 264..283
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 7..96
FT /note="Solcar 1"
FT REPEAT 104..189
FT /note="Solcar 2"
FT REPEAT 198..289
FT /note="Solcar 3"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000250|UniProtKB:Q5SVS4"
SQ SEQUENCE 291 AA; 32365 MW; 9F405B9F36DE9702 CRC64;
MSALNWKPFV YGGLASITAE CGTFPIDLTK TRLQIQGQTN DAKFREIRYR GMLHALMRIG
REEGLRALYS GIAPAMLRQA SYGTIKIGTY QSLKRLAVER PEDETLLINV VCGILSGVIS
SAIANPTDVL KIRMQAQNSA VQGGMIGNFI SIYQQEGTRG LWKGVSLTAQ RAAIVVGVEL
PVYDITKKHL ILSGLMGDTV STHFLSSFTC GLVGALASNP VDVVRTRMMN QRDLRDGRCS
GYKGTLDCLL QTWKNEGFFA LYKGFWPNWL RLGPWNIIFF LTYEQLKKLD L