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KMCP1_RAT
ID   KMCP1_RAT               Reviewed;         291 AA.
AC   Q5PQM9;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Kidney mitochondrial carrier protein 1;
DE   AltName: Full=Solute carrier family 25 member 30;
GN   Name=Slc25a30; Synonyms=Kmcp1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Probable transporter. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with VDAC1. {ECO:0000250|UniProtKB:Q5SVS4}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; BC087106; AAH87106.1; -; mRNA.
DR   RefSeq; NP_001013205.1; NM_001013187.1.
DR   RefSeq; XP_008769095.1; XM_008770873.2.
DR   AlphaFoldDB; Q5PQM9; -.
DR   SMR; Q5PQM9; -.
DR   STRING; 10116.ENSRNOP00000001389; -.
DR   jPOST; Q5PQM9; -.
DR   Ensembl; ENSRNOT00000104191; ENSRNOP00000097957; ENSRNOG00000001052.
DR   GeneID; 361074; -.
DR   KEGG; rno:361074; -.
DR   UCSC; RGD:1359702; rat.
DR   CTD; 253512; -.
DR   RGD; 1359702; Slc25a30.
DR   GeneTree; ENSGT00940000158961; -.
DR   InParanoid; Q5PQM9; -.
DR   OrthoDB; 1126848at2759; -.
DR   PRO; PR:Q5PQM9; -.
DR   Proteomes; UP000002494; Chromosome 15.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; ISO:RGD.
DR   GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
DR   GO; GO:0015140; F:malate transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015131; F:oxaloacetate transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015141; F:succinate transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015116; F:sulfate transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015117; F:thiosulfate transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0071423; P:malate transmembrane transport; IBA:GO_Central.
DR   GO; GO:0015729; P:oxaloacetate transport; IBA:GO_Central.
DR   GO; GO:0035435; P:phosphate ion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0071422; P:succinate transmembrane transport; IBA:GO_Central.
DR   GO; GO:0008272; P:sulfate transport; IBA:GO_Central.
DR   GO; GO:0015709; P:thiosulfate transport; IBA:GO_Central.
DR   Gene3D; 1.50.40.10; -; 1.
DR   InterPro; IPR002067; Mit_carrier.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 3.
DR   PRINTS; PR00926; MITOCARRIER.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   2: Evidence at transcript level;
KW   Acetylation; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q5SVS4"
FT   CHAIN           2..291
FT                   /note="Kidney mitochondrial carrier protein 1"
FT                   /id="PRO_0000288919"
FT   TRANSMEM        9..26
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..89
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        106..124
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        164..183
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        204..224
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        264..283
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          7..96
FT                   /note="Solcar 1"
FT   REPEAT          104..189
FT                   /note="Solcar 2"
FT   REPEAT          198..289
FT                   /note="Solcar 3"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5SVS4"
SQ   SEQUENCE   291 AA;  32365 MW;  9F405B9F36DE9702 CRC64;
     MSALNWKPFV YGGLASITAE CGTFPIDLTK TRLQIQGQTN DAKFREIRYR GMLHALMRIG
     REEGLRALYS GIAPAMLRQA SYGTIKIGTY QSLKRLAVER PEDETLLINV VCGILSGVIS
     SAIANPTDVL KIRMQAQNSA VQGGMIGNFI SIYQQEGTRG LWKGVSLTAQ RAAIVVGVEL
     PVYDITKKHL ILSGLMGDTV STHFLSSFTC GLVGALASNP VDVVRTRMMN QRDLRDGRCS
     GYKGTLDCLL QTWKNEGFFA LYKGFWPNWL RLGPWNIIFF LTYEQLKKLD L
 
 
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