KN14H_ARATH
ID KN14H_ARATH Reviewed; 1040 AA.
AC F4HZF0; O80491;
DT 02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2016, sequence version 2.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Kinesin-like protein KIN-14H {ECO:0000305};
GN Name=KIN14H {ECO:0000305};
GN OrderedLocusNames=At1g09170 {ECO:0000312|Araport:AT1G09170};
GN ORFNames=T12M4.14 {ECO:0000312|EMBL:AAC24096.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY.
RX PubMed=11472632; DOI=10.1186/1471-2164-2-2;
RA Reddy A.S., Day I.S.;
RT "Kinesins in the Arabidopsis genome: a comparative analysis among
RT eukaryotes.";
RL BMC Genomics 2:2-2(2001).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16448571; DOI=10.1186/1471-2164-7-18;
RA Richardson D.N., Simmons M.P., Reddy A.S.;
RT "Comprehensive comparative analysis of kinesins in photosynthetic
RT eukaryotes.";
RL BMC Genomics 7:18-18(2006).
RN [5]
RP REVIEW.
RX PubMed=22038119; DOI=10.1007/s00709-011-0343-9;
RA Zhu C., Dixit R.;
RT "Functions of the Arabidopsis kinesin superfamily of microtubule-based
RT motor proteins.";
RL Protoplasma 249:887-899(2012).
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. KIN-14 subfamily.
CC {ECO:0000303|PubMed:16448571}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC24096.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AEE28407.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC003114; AAC24096.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE28407.1; ALT_SEQ; Genomic_DNA.
DR PIR; B86224; B86224.
DR RefSeq; NP_172389.2; NM_100787.3.
DR AlphaFoldDB; F4HZF0; -.
DR SMR; F4HZF0; -.
DR STRING; 3702.AT1G09170.1; -.
DR PaxDb; F4HZF0; -.
DR PeptideAtlas; F4HZF0; -.
DR PRIDE; F4HZF0; -.
DR GeneID; 837437; -.
DR KEGG; ath:AT1G09170; -.
DR Araport; AT1G09170; -.
DR TAIR; locus:2195316; AT1G09170.
DR eggNOG; KOG0239; Eukaryota.
DR HOGENOM; CLU_001485_8_0_1; -.
DR InParanoid; F4HZF0; -.
DR PRO; PR:F4HZF0; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; F4HZF0; baseline and differential.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0015630; C:microtubule cytoskeleton; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR GO; GO:0007017; P:microtubule-based process; IBA:GO_Central.
DR Gene3D; 1.10.418.10; -; 1.
DR Gene3D; 3.40.850.10; -; 1.
DR InterPro; IPR001715; CH-domain.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00033; CH; 1.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF47576; SSF47576; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Coiled coil; Microtubule; Motor protein; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..1040
FT /note="Kinesin-like protein KIN-14H"
FT /id="PRO_0000438043"
FT DOMAIN 54..176
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT DOMAIN 434..754
FT /note="Kinesin motor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
FT REGION 208..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 809..871
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 887..926
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 969..1040
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 761..796
FT /evidence="ECO:0000255"
FT COMPBIAS 213..242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 809..856
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 969..992
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1000..1040
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 517..524
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1040 AA; 114914 MW; 647364E120A9A951 CRC64;
MATEQQDSQL CLATILEDFL KQRNIQVSVG VDSSSLKKAD ETFGGRDLPV DPSDLRRYEA
ARWVRNTLGV VGGRDLPADP SEEDFRIALR SGILLCNVLN RVKPGAVPKV VEAPNDPLVN
QDGAALSAFQ YFENLRNFLV FVEEMGIPTF EVSDFEKGGK SARIVECVLA LKSYREWKQS
GGSGTWRYIL NSKPTTFGIA KQYKRKDSEV PVDAVTNSPS STPSSEQPLL DQSDSNTKND
GTASSIDAIV RAVFSDMKQE DIPVIVEDML KSVMVEYERR LATQNELLLM SAGNRDKLGS
GDLGRTISGN EETLSDASYG EENVTEIVNN NMEASQDSNV EELENQDYEL YAISKEKTEK
QQLIIERQQT HTEELKHDLK AVKAGLSLLQ MKYQQEFTSL GKHLHGLTYA ATGYQRVLEE
NRKLYNQVQD LKGSIRVYCR VRPFLPGQKS VLTTVDHLED STLSIATPSK YGKEGQKTFT
FNKVFGPSAS QEAVFADTQP LIRSVLDGYN VCIFAYGQTG SGKTFTMMGP NELTDETLGV
NYRALSDLFH LSSVRKETFS YNISVQMLEI YNEQVRDLLA TNEIRNSTQD GINVPEATLV
PVSTTSDVIH LMNIGQKNRA VSATAMNDRS SRSHSCLTVH VQGKDLTSGV TLRGSMHLVD
LAGSERIDKS EVTGDRLKEA QHINKSLSAL GDVIASLSQK NNHIPYRNSK LTQLLQDALG
GQAKTLMFIH ISPELEDLGE TLSTLKFAER VATVDLGAAR VNKDTSEVKE LKEQIASLKL
ALARKESGAD QTQLQRPLTP DKLLRKKSLG VSSSFSKSAN STRQVQTKHK PSQIDDVNSI
EGQSDSASSL DLQGLVGSPS WKTPPRDGKE EDMEFIIPGS EWVDKHEDEI TRSSKPENRA
HTQLEKRTSS LKREATRGVD KNKCNSSVDK GLEVRKIPYE EEANESDETA TSDCSETNLM
WQLNVQVNMP RPASNGSSTK LKKNQSKISR VAAETRSMIP SLIPTPTRTL SLGAAISSPG
QTSSRHNNST VVVKKRQNPK
