KN14I_ARATH
ID KN14I_ARATH Reviewed; 983 AA.
AC F4IL57; O22260; Q84W97;
DT 02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Kinesin-like protein KIN-14I {ECO:0000305};
GN Name=KIN14I {ECO:0000305};
GN OrderedLocusNames=At2g47500 {ECO:0000312|Araport:AT2G47500};
GN ORFNames=T30B22.20 {ECO:0000312|EMBL:AAC62860.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY.
RX PubMed=11472632; DOI=10.1186/1471-2164-2-2;
RA Reddy A.S., Day I.S.;
RT "Kinesins in the Arabidopsis genome: a comparative analysis among
RT eukaryotes.";
RL BMC Genomics 2:2-2(2001).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16448571; DOI=10.1186/1471-2164-7-18;
RA Richardson D.N., Simmons M.P., Reddy A.S.;
RT "Comprehensive comparative analysis of kinesins in photosynthetic
RT eukaryotes.";
RL BMC Genomics 7:18-18(2006).
RN [6]
RP REVIEW.
RX PubMed=22038119; DOI=10.1007/s00709-011-0343-9;
RA Zhu C., Dixit R.;
RT "Functions of the Arabidopsis kinesin superfamily of microtubule-based
RT motor proteins.";
RL Protoplasma 249:887-899(2012).
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. KIN-14 subfamily.
CC {ECO:0000303|PubMed:16448571}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC62860.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC002535; AAC62860.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC10851.1; -; Genomic_DNA.
DR EMBL; BT004088; AAO42115.1; -; mRNA.
DR PIR; T00434; T00434.
DR RefSeq; NP_850475.2; NM_180144.4.
DR AlphaFoldDB; F4IL57; -.
DR SMR; F4IL57; -.
DR STRING; 3702.AT2G47500.1; -.
DR iPTMnet; F4IL57; -.
DR PaxDb; F4IL57; -.
DR PRIDE; F4IL57; -.
DR ProteomicsDB; 250700; -.
DR EnsemblPlants; AT2G47500.1; AT2G47500.1; AT2G47500.
DR GeneID; 819363; -.
DR Gramene; AT2G47500.1; AT2G47500.1; AT2G47500.
DR KEGG; ath:AT2G47500; -.
DR Araport; AT2G47500; -.
DR TAIR; locus:2061992; AT2G47500.
DR eggNOG; KOG0239; Eukaryota.
DR HOGENOM; CLU_001485_8_0_1; -.
DR InParanoid; F4IL57; -.
DR OrthoDB; 364605at2759; -.
DR PRO; PR:F4IL57; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; F4IL57; baseline and differential.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0015630; C:microtubule cytoskeleton; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR GO; GO:0007017; P:microtubule-based process; IBA:GO_Central.
DR Gene3D; 1.10.418.10; -; 1.
DR Gene3D; 3.40.850.10; -; 1.
DR InterPro; IPR001715; CH-domain.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00033; CH; 1.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF47576; SSF47576; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Coiled coil; Microtubule; Motor protein; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..983
FT /note="Kinesin-like protein KIN-14I"
FT /id="PRO_0000438044"
FT DOMAIN 44..166
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT DOMAIN 399..724
FT /note="Kinesin motor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
FT REGION 203..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 276..295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 802..824
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 921..983
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 731..758
FT /evidence="ECO:0000255"
FT COMPBIAS 937..956
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 481..488
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
FT CONFLICT 774
FT /note="H -> Y (in Ref. 3; AAO42115)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 983 AA; 108779 MW; 5C644AB36678F909 CRC64;
MAATATEDGG LSFTVASVME DVLQQHGNGL RDHDLVSRRA EEAASRRYEA ANWLRRMVGV
VGAKDLPAEP TEEGLRLGLR SGIILCKVLN KVQPGAVSKV VESPCDAILV ADGAPLSAFQ
YFENVRNFLV AIQEMGFPTF EASDLEQGGN ASRVVNCVLA IKSYDEWKQS GGIGVWKFGG
NIKPPALGKS SFVRKNSEPF MNSLSRTSSI NNEKAPSEND SNKLSSPSSL STLVRAVLSD
KKPEDVPKLI ESLLSKVVEE FENRVTNQYE LVRAAPREST SSQNNRSFLK PLGEREREEK
SFKAIKKDDH NSQILDEKMK TRQFKQLTIF NQQQEDIEGL RQTLYTTRAG MQFMQKKFQE
EFSSLGMHVH GLAHAASGYH RVLEENRKLY NQVQDLKGSI RVYCRVRPFL PGQSSFSSTI
GNMEDDTIGI NTASRHGKSL KSFTFNKVFG PSATQEEVFS DMQPLIRSVL DGYNVCIFAY
GQTGSGKTFT MSGPRDLTEK SQGVNYRALG DLFLLAEQRK DTFRYDIAVQ MIEIYNEQVR
DLLVTDGSNK RLEIRNSSQK GLSVPDASLV PVSSTFDVID LMKTGHKNRA VGSTALNDRS
SRSHSCLTVH VQGRDLTSGA VLRGCMHLVD LAGSERVDKS EVTGDRLKEA QHINRSLSAL
GDVIASLAHK NPHVPYRNSK LTQLLQDSLG GQAKTLMFVH ISPEADAVGE TISTLKFAER
VATVELGAAR VNNDTSDVKE LKEQIATLKA ALARKEAESQ QNNILKTPGG SEKHKAKTGE
VEIHNNNIMT KKSESCEVEE ITVNSPPWPP VASPGQAYRE DDRSFGSSEW VDKVMVNNRQ
DEMRRVESLW GGATTENGIG ILPEDFYRRD LASDTSRIFS EHSYNIFMGN NNSTDDLDAA
TSDSSEPDLL WQFNQSTKIP TRSNIESKLK KPVSKPIRSP QSRNNSNNTV SRPLASQKVG
NGPRGMKQFG PADMKRKATN ARH
