KN14L_ARATH
ID KN14L_ARATH Reviewed; 955 AA.
AC F4J2M6; Q9SS42;
DT 02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2016, sequence version 2.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Kinesin-like protein KIN-14L {ECO:0000305};
GN Name=KIN14L {ECO:0000305};
GN OrderedLocusNames=At3g10310 {ECO:0000312|Araport:AT3G10310};
GN ORFNames=F14P13.9 {ECO:0000312|EMBL:AAF02812.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY.
RX PubMed=11472632; DOI=10.1186/1471-2164-2-2;
RA Reddy A.S., Day I.S.;
RT "Kinesins in the Arabidopsis genome: a comparative analysis among
RT eukaryotes.";
RL BMC Genomics 2:2-2(2001).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16448571; DOI=10.1186/1471-2164-7-18;
RA Richardson D.N., Simmons M.P., Reddy A.S.;
RT "Comprehensive comparative analysis of kinesins in photosynthetic
RT eukaryotes.";
RL BMC Genomics 7:18-18(2006).
RN [5]
RP REVIEW.
RX PubMed=22038119; DOI=10.1007/s00709-011-0343-9;
RA Zhu C., Dixit R.;
RT "Functions of the Arabidopsis kinesin superfamily of microtubule-based
RT motor proteins.";
RL Protoplasma 249:887-899(2012).
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. KIN-14 subfamily.
CC {ECO:0000303|PubMed:16448571}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF02812.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC009400; AAF02812.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; F4J2M6; -.
DR SMR; F4J2M6; -.
DR STRING; 3702.AT3G10310.1; -.
DR PaxDb; F4J2M6; -.
DR PeptideAtlas; F4J2M6; -.
DR PRIDE; F4J2M6; -.
DR ProteomicsDB; 238191; -.
DR Araport; AT3G10310; -.
DR TAIR; locus:2076289; AT3G10310.
DR eggNOG; KOG0239; Eukaryota.
DR HOGENOM; CLU_001485_8_1_1; -.
DR InParanoid; F4J2M6; -.
DR PRO; PR:F4J2M6; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; F4J2M6; baseline and differential.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0015630; C:microtubule cytoskeleton; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR GO; GO:0007017; P:microtubule-based process; IBA:GO_Central.
DR Gene3D; 1.10.418.10; -; 1.
DR Gene3D; 3.40.850.10; -; 1.
DR InterPro; IPR001715; CH-domain.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00033; CH; 1.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF47576; SSF47576; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Coiled coil; Microtubule; Motor protein; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..955
FT /note="Kinesin-like protein KIN-14L"
FT /id="PRO_0000438047"
FT DOMAIN 19..140
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT DOMAIN 363..685
FT /note="Kinesin motor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
FT REGION 878..942
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 692..719
FT /evidence="ECO:0000255"
FT COMPBIAS 894..913
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 445..452
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 955 AA; 107010 MW; 6EF3DB1AA7E421FB CRC64;
MTTGLHEFNL ASRRAEEAAA RRFQAVQWLK SVVGQLGIPN QPSEKEFISC LRNGMILCNA
INKIHPGAVS KVVENYSYLN GEYQLPPAYQ YFENVRNFLV ALETLRLPGF EASDLEKDNL
ESGSVTKVVD CILGLKAYHE CKLPSNGNGL YKHVKTPTFQ LSATKIHPTL SASKTSRHLD
MSSVRERNDC TDGESDKLKG IAKLFADHIF SSKENIDENL VSLENGSENS RANFEKILSR
FPELQSVFKN LLSEGTLKPS DLKSMPLEEL PVHEEDQSSR SLSHKTKCNH KRLLKTQEKE
LAVLKNLFIK TKQDFKEFQV YLQRDLMELG NQMQEMSSAA QGYYKVVEEN RKLYNMVQDL
KGNIRVYCRV RPIFNSEMDG VIDYIGKDGS LFVLDPSKPY KDARKTFQFN QVFGPTATQD
DVFRETQPLI RSVMDGYNVC IFAYGQTGSG KTYTMSGPPG RSATEMGINY LALSDLFLIC
DRRKDMMTYE IYVQMVEIYN EQVRDLLAEN SSYIRTCSSD DDGLSLPDAT MHSVNSTKDV
LQLMEAGEVN RAVSSTSMNN RSSRSHSIFM VHVRGKDTSG GTLRSCLHLV DLAGSERVDK
SEVTGDRLKE AQYINKSLSC LGDVISALAQ KNSHIPYRNS KLTLLLQDSL GGQAKTLMFA
HLSPEEDSFG ETISTLKFAQ RVSTVELGAA RAHKETREVM HLKEQIENLK RALGTEEWNN
VSNGSKEIKS PFSRPIATTE RTPPRLRRLS IENCSSTKAN LEDRRGIKSP LASRRAQILS
LEGPMSCKNE ENGKGDPTME VHQLKNPRSP LSSYQNRAVK VDGRTSIPQL QLLQTPVKGA
SRNDIQMISV DSKTNGKGSH IRKSLRTIGK LINGSEKRKE NIPADPRSPL GVANNFSHIK
SPDTSNAKTM RRQSLTGVMP PGQERSRRSS IGGKPIENGK KDHVFTPFRL NKFNN
