KN14Q_ARATH
ID KN14Q_ARATH Reviewed; 1203 AA.
AC F4IBQ9; Q9C7T0;
DT 02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Kinesin-like protein KIN-14Q {ECO:0000305};
GN Name=KIN14Q {ECO:0000305};
GN OrderedLocusNames=At1g72250 {ECO:0000312|Araport:AT1G72250};
GN ORFNames=T9N14.6 {ECO:0000312|EMBL:AAG51794.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY.
RX PubMed=11472632; DOI=10.1186/1471-2164-2-2;
RA Reddy A.S., Day I.S.;
RT "Kinesins in the Arabidopsis genome: a comparative analysis among
RT eukaryotes.";
RL BMC Genomics 2:2-2(2001).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16448571; DOI=10.1186/1471-2164-7-18;
RA Richardson D.N., Simmons M.P., Reddy A.S.;
RT "Comprehensive comparative analysis of kinesins in photosynthetic
RT eukaryotes.";
RL BMC Genomics 7:18-18(2006).
RN [5]
RP REVIEW.
RX PubMed=22038119; DOI=10.1007/s00709-011-0343-9;
RA Zhu C., Dixit R.;
RT "Functions of the Arabidopsis kinesin superfamily of microtubule-based
RT motor proteins.";
RL Protoplasma 249:887-899(2012).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=F4IBQ9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=F4IBQ9-2; Sequence=VSP_058607;
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. KIN-14 subfamily.
CC {ECO:0000303|PubMed:16448571}.
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DR EMBL; AC067754; AAG51794.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE35293.1; -; Genomic_DNA.
DR PIR; B96746; B96746.
DR RefSeq; NP_177370.1; NM_105884.2. [F4IBQ9-2]
DR AlphaFoldDB; F4IBQ9; -.
DR SMR; F4IBQ9; -.
DR STRING; 3702.AT1G72250.2; -.
DR PaxDb; F4IBQ9; -.
DR PeptideAtlas; F4IBQ9; -.
DR EnsemblPlants; AT1G72250.1; AT1G72250.1; AT1G72250. [F4IBQ9-2]
DR GeneID; 843557; -.
DR Gramene; AT1G72250.1; AT1G72250.1; AT1G72250. [F4IBQ9-2]
DR KEGG; ath:AT1G72250; -.
DR Araport; AT1G72250; -.
DR TAIR; locus:2207011; AT1G72250.
DR eggNOG; KOG0239; Eukaryota.
DR HOGENOM; CLU_007631_0_0_1; -.
DR InParanoid; F4IBQ9; -.
DR PRO; PR:F4IBQ9; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; F4IBQ9; baseline and differential.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0015630; C:microtubule cytoskeleton; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR GO; GO:0007017; P:microtubule-based process; IBA:GO_Central.
DR Gene3D; 3.40.850.10; -; 1.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR021720; Malectin_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF11721; Malectin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW Alternative splicing; ATP-binding; Coiled coil; Microtubule; Motor protein;
KW Nucleotide-binding; Reference proteome.
FT CHAIN 1..1203
FT /note="Kinesin-like protein KIN-14Q"
FT /id="PRO_0000438050"
FT DOMAIN 499..825
FT /note="Kinesin motor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 907..931
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 336..395
FT /evidence="ECO:0000255"
FT COILED 846..901
FT /evidence="ECO:0000255"
FT COMPBIAS 917..931
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 582..589
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
FT VAR_SEQ 406..434
FT /note="AFAVEGQVKEKSRWFSSLRDLTRKLKIMK -> GTSQREEQMVLFIKRFDKK
FT IE (in isoform 2)"
FT /id="VSP_058607"
SQ SEQUENCE 1203 AA; 134254 MW; E4E8846CAE92DC34 CRC64;
MEDCCDPLLA TDASPRPESF SRSEKDIASR SRTVAMADLD SNCELSNDVD MEQSSPDLMK
LEQSSDPVAL DGKVVLGFSL ASPDLVNCGA SPDLPRGSYE DSPEFSKKRR FSTELSLENG
IDGSTTTTRL GRKSQVVKFS AICQTFGYEL SPESSFELPS PPGDFRESMT PVISINSGSI
STDVTVEDVT FLKDEFFSGG ESITTDAVVG NEDEILLYQT ARLGNFAYKF QSLDPGDYFI
DLHFAEIEFT KGPPGVISGL DLFSQVGANT PLVIEDLRML VGREGELSIR LEGVTGAAIL
CGISIRKETT ATYVEETGML AVKGSTDTVL SQQTQENLVC RAEEEAEGMR SDCEQQRKEM
EDMKRMVEEL KLENQQKTRE CEEALNSLSE IQNELMRKSM HVGSLAFAVE GQVKEKSRWF
SSLRDLTRKL KIMKVEQIKL LEEATTYKHL VQDINEFSSH IQSRVKQDAE LHENLKVKFV
AGEKERKELY NKILELKGNI RVFCRCRPLN FEETEAGVSM GIDVESTKNG EVIVMSNGFP
KKSFKFDSVF GPNASQADVF EDTAPFATSV IDGYNVCIFA YGQTGTGKTF TMEGTQHDRG
VNYRTLENLF RIIKAREHRY NYEISVSVLE VYNEQIRDLL VPASQSASAP KRFEIRQLSE
GNHHVPGLVE APVKSIEEVW DVLKTGSNAR AVGKTTANEH SSRSHCIHCV MVKGENLLNG
ECTKSKLWLV DLAGSERVAK TEVQGERLKE TQNINKSLSA LGDVIFALAN KSSHIPFRNS
KLTHLLQDSL GGDSKTLMFV QISPNENDQS ETLCSLNFAS RVRGIELGPA KKQLDNTELL
KYKQMVEKWK QDMKGKDEQI RKMEETMYGL EAKIKERDTK NKTLQDKVKE LESQLLVERK
LARQHVDTKI AEQQTKQQTE DENNTSKRPP LTNILLGSAS KEMVNLTRPS LLESTTSYDL
APLPSGVPKY NDLSEKENNP EMADQVHLPN KTGRFSICAK RIPSAPAPRR SSLAPTTSTS
REMVYLTRPP LSESTTSYDL PPLPNGGLKY SDLIEKVNNQ EMAEQVQIPK RIGAGRSSIC
AKRIPPAPRR KSFAPMPFIP ITSTLTSPDE KSGANQVLCT SPKLHRSNGK TLTSILRRSI
QKRMQMKPSP RQQPMRRGGG INVGMERVRL SIGNRGRLAH RVLLTNARKA GLKETPQKQE
RWI
