KN14R_ARATH
ID KN14R_ARATH Reviewed; 1083 AA.
AC F4IJK6; F4IJK7; Q9ZQ52;
DT 02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Kinesin-like protein KIN-14R {ECO:0000305};
GN Name=KIN14R {ECO:0000305};
GN OrderedLocusNames=At2g22610 {ECO:0000312|Araport:AT2G22610};
GN ORFNames=T9I22.5 {ECO:0000312|EMBL:AAD15569.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY.
RX PubMed=11472632; DOI=10.1186/1471-2164-2-2;
RA Reddy A.S., Day I.S.;
RT "Kinesins in the Arabidopsis genome: a comparative analysis among
RT eukaryotes.";
RL BMC Genomics 2:2-2(2001).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16448571; DOI=10.1186/1471-2164-7-18;
RA Richardson D.N., Simmons M.P., Reddy A.S.;
RT "Comprehensive comparative analysis of kinesins in photosynthetic
RT eukaryotes.";
RL BMC Genomics 7:18-18(2006).
RN [5]
RP REVIEW.
RX PubMed=22038119; DOI=10.1007/s00709-011-0343-9;
RA Zhu C., Dixit R.;
RT "Functions of the Arabidopsis kinesin superfamily of microtubule-based
RT motor proteins.";
RL Protoplasma 249:887-899(2012).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=F4IJK6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=F4IJK6-2; Sequence=VSP_058608;
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. KIN-14 subfamily.
CC {ECO:0000303|PubMed:16448571}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD15569.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC006340; AAD15569.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC07327.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC07328.1; -; Genomic_DNA.
DR PIR; F84614; F84614.
DR RefSeq; NP_001189577.1; NM_001202648.1. [F4IJK6-2]
DR RefSeq; NP_179846.3; NM_127826.5. [F4IJK6-1]
DR AlphaFoldDB; F4IJK6; -.
DR SMR; F4IJK6; -.
DR STRING; 3702.AT2G22610.1; -.
DR PaxDb; F4IJK6; -.
DR PRIDE; F4IJK6; -.
DR EnsemblPlants; AT2G22610.1; AT2G22610.1; AT2G22610. [F4IJK6-1]
DR EnsemblPlants; AT2G22610.2; AT2G22610.2; AT2G22610. [F4IJK6-2]
DR GeneID; 816792; -.
DR Gramene; AT2G22610.1; AT2G22610.1; AT2G22610. [F4IJK6-1]
DR Gramene; AT2G22610.2; AT2G22610.2; AT2G22610. [F4IJK6-2]
DR KEGG; ath:AT2G22610; -.
DR Araport; AT2G22610; -.
DR TAIR; locus:2066030; AT2G22610.
DR eggNOG; KOG0239; Eukaryota.
DR HOGENOM; CLU_006519_0_1_1; -.
DR InParanoid; F4IJK6; -.
DR OMA; DECYQSW; -.
DR PRO; PR:F4IJK6; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; F4IJK6; baseline and differential.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0015630; C:microtubule cytoskeleton; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR GO; GO:0007017; P:microtubule-based process; IBA:GO_Central.
DR Gene3D; 3.40.850.10; -; 1.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR021720; Malectin_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF11721; Malectin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW Alternative splicing; ATP-binding; Coiled coil; Microtubule; Motor protein;
KW Nucleotide-binding; Reference proteome.
FT CHAIN 1..1083
FT /note="Kinesin-like protein KIN-14R"
FT /id="PRO_0000438051"
FT DOMAIN 417..739
FT /note="Kinesin motor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
FT REGION 967..1083
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 264..418
FT /evidence="ECO:0000255"
FT COILED 746..876
FT /evidence="ECO:0000255"
FT COILED 905..947
FT /evidence="ECO:0000255"
FT COMPBIAS 970..985
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 987..1035
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1042..1056
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1060..1083
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 500..507
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
FT VAR_SEQ 861..881
FT /note="Missing (in isoform 2)"
FT /id="VSP_058608"
SQ SEQUENCE 1083 AA; 122922 MW; 845E437D2561B751 CRC64;
MDDVQIDDTF PVDLNGVTSL CSPEIPSFDF VSDETEKLEI GDTSIDDCDD ALGDSMVCDP
NSRLVPTGLT RTNRTDETIM FINAGGDDSK VLDSELNISR DDYFEGGDVL RTEESIVEAG
DFPFIYQSAR VGNFCYQLNN LLPGEYLIDF HFAEIINTNG PKGIRVFNVY VQDEKATEFD
IFSVVGANRP LLLVDLRVMV MDDGLIRVRF EGINGSPVVC GICLRKAPQV SVPRTSQDFI
KCENCATEIE ISPTRKRLMR AKAHDKYEKK IAELSERYEH KTNECHEAWM SLTSANEQLE
KVMMELNNKI YQARSLDQTV ITQADCLKSI TRKYENDKRH WATAIDSLQE KIEIMKREQS
QLSQEAHECV EGIPELYKMV GGVQALVSQC EDLKQKYSEE QAKRKELYNH IQETKGNIRV
FCRCRPLNTE ETSTKSATIV DFDGAKDGEL GVITGNNSKK SFKFDRVYTP KDGQVDVFAD
ASPMVVSVLD GYNVCIFAYG QTGTGKTFTM EGTPQNRGVN YRTVEQLFEV ARERRETISY
NISVSVLEVY NEQIRDLLAT SPGSKKLEIK QSSDGSHHVP GLVEANVENI NEVWNVLQAG
SNARSVGSNN VNEHSSRSHC MLSIMVKAKN LMNGDCTKSK LWLVDLAGSE RLAKTDVQGE
RLKEAQNINR SLSALGDVIY ALATKSSHIP YRNSKLTHLL QDSLGGDSKT LMFVQISPSE
HDVSETLSSL NFATRVRGVE LGPARKQVDT GEIQKLKAMV EKARQESRSK DESIKKMEEN
IQNLEGKNKG RDNSYRSLQE KNKDLQNQLD SVHNQSEKQY AQLQERLKSR DEICSNLQQK
VKELECKLRE RHQSDSAANN QKVKDLENNL KESEGSSLVW QQKVKDYENK LKESEGNSLV
WQQKIKELEI KHKDEQSQEA VLLRQKIKEL EMRLKEQEKH IQEMATTREF PEVANATPNE
VKTCFKEDNF GNENMESNTN ILRTSNRLKT KRHDSLNLNE MTRKKRASRS GETENNGDDP
QMKEKRIRKS DPPKVFSRVV RPTRTASGSS SQVPVAQKRV IKREQQEVPV VKERDSKKKI
WSR
