ID   KN14S_ARATH             Reviewed;         765 AA.
AC   F4K4C5;
DT   02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Kinesin-like protein KIN-14S {ECO:0000305};
GN   Name=KIN14S {ECO:0000305};
GN   OrderedLocusNames=At5g27550 {ECO:0000312|Araport:AT5G27550};
GN   ORFNames=F15A18 {ECO:0000312|EMBL:AC007478},
GN   F21A20 {ECO:0000312|EMBL:AC007123};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130714; DOI=10.1038/35048507;
RA   Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA   Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA   Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA   Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA   Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA   O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA   Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA   Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA   Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA   Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA   Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA   Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA   Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA   Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA   Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA   Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA   McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA   Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA   Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA   Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA   Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA   Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA   Bevan M., Fransz P.F.;
RT   "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL   Nature 408:823-826(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   GENE FAMILY.
RX   PubMed=11472632; DOI=10.1186/1471-2164-2-2;
RA   Reddy A.S., Day I.S.;
RT   "Kinesins in the Arabidopsis genome: a comparative analysis among
RT   eukaryotes.";
RL   BMC Genomics 2:2-2(2001).
RN   [4]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=16448571; DOI=10.1186/1471-2164-7-18;
RA   Richardson D.N., Simmons M.P., Reddy A.S.;
RT   "Comprehensive comparative analysis of kinesins in photosynthetic
RT   eukaryotes.";
RL   BMC Genomics 7:18-18(2006).
RN   [5]
RP   REVIEW.
RX   PubMed=22038119; DOI=10.1007/s00709-011-0343-9;
RA   Zhu C., Dixit R.;
RT   "Functions of the Arabidopsis kinesin superfamily of microtubule-based
RT   motor proteins.";
RL   Protoplasma 249:887-899(2012).
CC   -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC       superfamily. Kinesin family. KIN-14 subfamily.
CC       {ECO:0000303|PubMed:16448571}.
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DR   EMBL; AC007123; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC007478; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CP002688; AED93700.1; -; Genomic_DNA.
DR   EMBL; CP002688; ANM69400.1; -; Genomic_DNA.
DR   RefSeq; NP_001318663.1; NM_001344014.1.
DR   RefSeq; NP_198107.3; NM_122637.4.
DR   AlphaFoldDB; F4K4C5; -.
DR   SMR; F4K4C5; -.
DR   STRING; 3702.AT5G27550.1; -.
DR   PaxDb; F4K4C5; -.
DR   PRIDE; F4K4C5; -.
DR   ProteomicsDB; 238200; -.
DR   EnsemblPlants; AT5G27550.1; AT5G27550.1; AT5G27550.
DR   EnsemblPlants; AT5G27550.2; AT5G27550.2; AT5G27550.
DR   GeneID; 832815; -.
DR   Gramene; AT5G27550.1; AT5G27550.1; AT5G27550.
DR   Gramene; AT5G27550.2; AT5G27550.2; AT5G27550.
DR   KEGG; ath:AT5G27550; -.
DR   Araport; AT5G27550; -.
DR   TAIR; locus:2143616; AT5G27550.
DR   eggNOG; KOG0239; Eukaryota.
DR   HOGENOM; CLU_007631_2_1_1; -.
DR   InParanoid; F4K4C5; -.
DR   OMA; HPEICSD; -.
DR   OrthoDB; 364605at2759; -.
DR   PRO; PR:F4K4C5; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; F4K4C5; baseline and differential.
DR   GO; GO:0005871; C:kinesin complex; IBA:GO_Central.
DR   GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR   GO; GO:0003777; F:microtubule motor activity; IBA:GO_Central.
DR   GO; GO:0008574; F:plus-end-directed microtubule motor activity; IBA:GO_Central.
DR   GO; GO:0030705; P:cytoskeleton-dependent intracellular transport; IBA:GO_Central.
DR   GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR   Gene3D; 3.40.850.10; -; 1.
DR   InterPro; IPR027640; Kinesin-like_fam.
DR   InterPro; IPR019821; Kinesin_motor_CS.
DR   InterPro; IPR001752; Kinesin_motor_dom.
DR   InterPro; IPR036961; Kinesin_motor_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR24115; PTHR24115; 1.
DR   Pfam; PF00225; Kinesin; 1.
DR   PRINTS; PR00380; KINESINHEAVY.
DR   SMART; SM00129; KISc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR   PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Coiled coil; Microtubule; Motor protein; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..765
FT                   /note="Kinesin-like protein KIN-14S"
FT                   /id="PRO_0000438052"
FT   DOMAIN          132..456
FT                   /note="Kinesin motor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
FT   REGION          581..613
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          654..678
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          469..534
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        655..669
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         215..222
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
SQ   SEQUENCE   765 AA;  85438 MW;  5F75C87D1509592C CRC64;
     MERDQHQEIC NDGGLLCESK EVSVNNHNSD AVEESEDTIT SGNQEVSPAN GPTLPILQKI
     IDCSDKIKIL KDEHALVSNQ VQEIKNCSLV EPEISRALQL LTTKLGALEK QYLEESSERK
     RLYNEVIELK GNIRVFCRCR PLNQAEIANG CASVAEFDTT QENELQILSS DSSKKHFKFD
     HVFKPDDGQE TVFAQTKPIV TSVLDGYNVC IFAYGQTGTG KTFTMEGTPE NRGVNYRTLE
     ELFRCSESKS HLMKFELSVS MLEVYNEKIR DLLVDNSNQP PKKLEVKQSA EGTQEVPGLV
     EAQVYNTDGV WDLLKKGYAV RSVGSTAANE QSSRSHCLLR VTVKGENLIN GQRTRSHLWL
     VDLAGSERVG KVEVEGERLK ESQFINKSLS ALGDVISALA SKTSHIPYRN SKLTHMLQNS
     LGGDCKTLMF VQISPSSADL GETLCSLNFA SRVRGIESGP ARKQADVSEL LKSKQMAEKL
     KHEEKETKKL QDNVQSLQLR LTAREHICRG LQDKVRDLEF QLAEERKTRI KQESRALATA
     SSTTTTTSRH LRETLPTIIE KKPPLAPTRM RMPLRRITNF MPQQQPSQGH SKRFSDTTFK
     ENNNSNRRSS SMDVNTLMKP RRSSIAFRPA PAPSAIASSN KTIMPRRRVS IATLRPEPSS
     LSSMETPSRP PPSFRGDPRK ARYSKLFSPD RNLVTPNAMK SSRFMKSPLG GGGSSWKPSH
     PTVIALQKKA VVWSPLKFKN RRPSLVAIRS SASSSSASDL LRREQ