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ARAG_SHIFL
ID   ARAG_SHIFL              Reviewed;         504 AA.
AC   Q83KP2; Q7UAB3;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 4.
DT   03-AUG-2022, entry version 138.
DE   RecName: Full=Arabinose import ATP-binding protein AraG {ECO:0000255|HAMAP-Rule:MF_01721};
DE            EC=7.5.2.12 {ECO:0000255|HAMAP-Rule:MF_01721};
GN   Name=araG {ECO:0000255|HAMAP-Rule:MF_01721};
GN   OrderedLocusNames=SF1946, S2039;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: Part of the ABC transporter complex AraFGH involved in
CC       arabinose import. Responsible for energy coupling to the transport
CC       system. {ECO:0000255|HAMAP-Rule:MF_01721}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O + L-arabinose(out) = ADP + H(+) + L-arabinose(in) +
CC         phosphate; Xref=Rhea:RHEA:30007, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17535, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.5.2.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01721};
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (AraG),
CC       two transmembrane proteins (AraH) and a solute-binding protein (AraF).
CC       {ECO:0000255|HAMAP-Rule:MF_01721}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01721}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01721}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. Arabinose
CC       importer (TC 3.A.1.2.2) family. {ECO:0000255|HAMAP-Rule:MF_01721}.
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DR   EMBL; AE005674; AAN43498.2; -; Genomic_DNA.
DR   EMBL; AE014073; AAP17328.1; -; Genomic_DNA.
DR   RefSeq; NP_707791.2; NC_004337.2.
DR   RefSeq; WP_001187792.1; NZ_WPGW01000033.1.
DR   AlphaFoldDB; Q83KP2; -.
DR   SMR; Q83KP2; -.
DR   STRING; 198214.SF1946; -.
DR   EnsemblBacteria; AAN43498; AAN43498; SF1946.
DR   EnsemblBacteria; AAP17328; AAP17328; S2039.
DR   GeneID; 1025151; -.
DR   KEGG; sfl:SF1946; -.
DR   KEGG; sfx:S2039; -.
DR   PATRIC; fig|198214.7.peg.2322; -.
DR   HOGENOM; CLU_000604_92_3_6; -.
DR   OrthoDB; 551294at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015612; F:ABC-type L-arabinose transporter activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0042882; P:L-arabinose transmembrane transport; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR017917; ABC_transptr_Ara_ATP-bd_AraG.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR43790:SF6; PTHR43790:SF6; 1.
DR   Pfam; PF00005; ABC_tran; 2.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
DR   PROSITE; PS51268; ARAG; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell inner membrane; Cell membrane; Membrane;
KW   Nucleotide-binding; Reference proteome; Repeat; Sugar transport;
KW   Translocase; Transport.
FT   CHAIN           1..504
FT                   /note="Arabinose import ATP-binding protein AraG"
FT                   /id="PRO_0000270480"
FT   DOMAIN          8..243
FT                   /note="ABC transporter 1"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01721"
FT   DOMAIN          256..499
FT                   /note="ABC transporter 2"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01721"
FT   BINDING         40..47
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01721"
SQ   SEQUENCE   504 AA;  54919 MW;  AE3FA7E33798A862 CRC64;
     MQQSTPYLSF RGIGKTFPGV KALTDISFDC YAGQVHALMG ENGAGKSTLL KILSGNYAPT
     TGSVVINGQE MSFSDTTAAL NAGVAIIYQE LHLVPEMTVA ENIYLGQLPH KGGIVNRSLL
     NYEAGLQLKH LGMDIDPDTP LKYLAIGQWQ MVEIAKALAR NAKIIAFDEP TSSLSAREIG
     NLFRVIRELR KEGRVILYVS HRMEEIFALS DAITVFKDGR YVKTFTDMQQ VDHDALVQAM
     VGRDIGDIYG WQPRSYGEER LRLDAVKALG VRTPISLAVR SGEIVGLFGL VGAGRSELMK
     GLFGGTQITA GQVYIDQQPI DIRKPSHAIA AGMMLCPEAR KAEGIIPVHS VRDNINISAR
     RKHVLGGCVI NNSWEENNAD QHIRSLNIKT PGAEQLIMNL SGGNQQKAIL GRWLSEEMKV
     ILLDEPTRGI DVGAKHEIYN VIYALAAQGV AVLFASSDLP EVLGVADRIV VMREGEIAGE
     LLHEQADERQ ALSLAMPKVS QAVA
 
 
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