ID   KN1_SOLLC               Reviewed;         355 AA.
AC   Q41330;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 114.
DE   RecName: Full=Homeotic protein knotted-1;
DE            Short=TKN1;
GN   Name=KN1;
OS   Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC   Solanum subgen. Lycopersicon.
OX   NCBI_TaxID=4081;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. SP+,93-137; TISSUE=Shoot;
RX   PubMed=8625411; DOI=10.1016/s0092-8674(00)81051-x;
RA   Hareven D., Gutfinger T., Parnis A., Eshed Y., Lifschitz E.;
RT   "The making of a compound leaf: genetic manipulation of leaf architecture
RT   in tomato.";
RL   Cell 84:735-744(1996).
CC   -!- FUNCTION: Appears to be involved in meristem formation and in the
CC       regulation of leaf morphology. Misexpression makes the leaf more
CC       compound which is always associated with growth retardation and loss of
CC       apical dominance, resulting in dwarfed, bushy plants. Probably binds to
CC       the DNA sequence 5'-TGAC-3'.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in the apical meristems, in the newly
CC       emerged lateral primordia in the floral bud, in their vascular bundles
CC       and in the cortex parenchyma of the floral pedicle. Also present in the
CC       lateral tips of leaf primordia.
CC   -!- SIMILARITY: Belongs to the TALE/KNOX homeobox family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00559}.
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DR   EMBL; U32247; AAC49251.1; -; mRNA.
DR   PIR; T07776; T07776.
DR   RefSeq; NP_001233807.2; NM_001246878.2.
DR   AlphaFoldDB; Q41330; -.
DR   SMR; Q41330; -.
DR   STRING; 4081.Solyc04g077210.2.1; -.
DR   PaxDb; Q41330; -.
DR   GeneID; 544007; -.
DR   KEGG; sly:544007; -.
DR   eggNOG; KOG0773; Eukaryota.
DR   InParanoid; Q41330; -.
DR   OrthoDB; 1171537at2759; -.
DR   Proteomes; UP000004994; Unplaced.
DR   ExpressionAtlas; Q41330; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR005539; ELK_dom.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR008422; Homeobox_KN_domain.
DR   InterPro; IPR005540; KNOX1.
DR   InterPro; IPR005541; KNOX2.
DR   Pfam; PF03789; ELK; 1.
DR   Pfam; PF05920; Homeobox_KN; 1.
DR   Pfam; PF03790; KNOX1; 1.
DR   Pfam; PF03791; KNOX2; 1.
DR   SMART; SM01188; ELK; 1.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM01255; KNOX1; 1.
DR   SMART; SM01256; KNOX2; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS51213; ELK; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..355
FT                   /note="Homeotic protein knotted-1"
FT                   /id="PRO_0000048955"
FT   DOMAIN          236..256
FT                   /note="ELK"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00559"
FT   DNA_BIND        257..320
FT                   /note="Homeobox; TALE-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          205..233
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   355 AA;  40179 MW;  3CDE90EA14A08567 CRC64;
     MENNNYNNHV SGENSGGQRG HFFYGGNQVL GGAAPIYGRG GDCYDPMIVK TEGGGSTSHH
     NHTFHYPSII RNHHHDSTET SGGGAGAGEV IEALKAKIIA HPQCSNLLDA YMDCQKVGAP
     PEVAARLSAV RQEFEARQRR SLTDRDVSKD PELDQFMEAY YDMLVKYREE LTRPLQEAME
     FMQKIEAQLN MLGNAPVRIF NSEDKCEGVG SSEEDQDNSG GETELPEIDP RAEDRELKNH
     LLRKYSGYLS SLKQELSKKK KKGKLPKDAR QKLITWWELH YKWPYPSESE KVALAESTGL
     DQKQINNWFI NQRKRHWKPS EDMQFMVMDG LHPQSAAALY MEGHYMGEGP FRLGQ