KN6_ARATH
ID KN6_ARATH Reviewed; 971 AA.
AC F4HR11; Q9LNT1;
DT 11-MAY-2016, integrated into UniProtKB/Swiss-Prot.
DT 11-MAY-2016, sequence version 2.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=Kinesin-like protein KIN-6 {ECO:0000305};
GN Name=KIN6 {ECO:0000305};
GN OrderedLocusNames=At1g20060 {ECO:0000312|Araport:AT1G20060};
GN ORFNames=T20H2.17 {ECO:0000312|EMBL:AAF79908.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY.
RX PubMed=11472632; DOI=10.1186/1471-2164-2-2;
RA Reddy A.S., Day I.S.;
RT "Kinesins in the Arabidopsis genome: a comparative analysis among
RT eukaryotes.";
RL BMC Genomics 2:2-2(2001).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16448571; DOI=10.1186/1471-2164-7-18;
RA Richardson D.N., Simmons M.P., Reddy A.S.;
RT "Comprehensive comparative analysis of kinesins in photosynthetic
RT eukaryotes.";
RL BMC Genomics 7:18-18(2006).
RN [5]
RP REVIEW.
RX PubMed=22038119; DOI=10.1007/s00709-011-0343-9;
RA Zhu C., Dixit R.;
RT "Functions of the Arabidopsis kinesin superfamily of microtubule-based
RT motor proteins.";
RL Protoplasma 249:887-899(2012).
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. KIN-6 subfamily.
CC {ECO:0000303|PubMed:16448571}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF79908.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AEE29929.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC022472; AAF79908.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE29929.1; ALT_SEQ; Genomic_DNA.
DR PIR; A86334; A86334.
DR RefSeq; NP_173434.4; NM_101860.4.
DR AlphaFoldDB; F4HR11; -.
DR SMR; F4HR11; -.
DR STRING; 3702.AT1G20060.1; -.
DR PaxDb; F4HR11; -.
DR PeptideAtlas; F4HR11; -.
DR PRIDE; F4HR11; -.
DR GeneID; 838594; -.
DR KEGG; ath:AT1G20060; -.
DR Araport; AT1G20060; -.
DR TAIR; locus:2198611; AT1G20060.
DR eggNOG; KOG0242; Eukaryota.
DR HOGENOM; CLU_001485_18_0_1; -.
DR InParanoid; F4HR11; -.
DR OrthoDB; 604899at2759; -.
DR PRO; PR:F4HR11; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; F4HR11; baseline and differential.
DR GO; GO:0005871; C:kinesin complex; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0003777; F:microtubule motor activity; IBA:GO_Central.
DR GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR Gene3D; 3.40.850.10; -; 1.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24115; PTHR24115; 2.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Microtubule; Motor protein; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..971
FT /note="Kinesin-like protein KIN-6"
FT /id="PRO_0000436274"
FT DOMAIN 76..460
FT /note="Kinesin motor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 93..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 700..856
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 872..917
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..113
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 708..745
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 762..779
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 796..829
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 830..844
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 872..886
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 202..209
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 971 AA; 108253 MW; 772AF86C11C5B032 CRC64;
MEEKQKSLSP PPCPSTVTVR RNPPRRARAT PFTTTTKPPL SSLACAKPHD VPTFPIDEIL
SIQIPQSEPK PAIAESLKIF LRIKPLRTFT KVTTTTKSRP RNVWPQNPSK KNNAKENRNP
EITKKVRKKD EEACITLNDS YSVTLTPPQS LQELKRSKTE VYEGFSHVFP ADCSQNDVYD
KMVQPLLEDF MKGKSGMLAA LGPSGSGKTH TVFGSLKDPG IVPITLRQIF KKNDESCSGS
LRSFNLSIFE ICSERGKGEK AYDLLGGESS ELSVQQSTIR GLKEVPIQNL EEAESLIGQA
MLKRATATTN SNSQSSRSQC IINIRASCNG FSNETKLQSS DAMLTIVDLA GAEREKRTGN
QAIDFGLPGT DPYFILFLMP TIPLTMNTRY LLAVTVGVPE EPKEGIAETS SKFFGSLTRY
LRDYLEGKKR MALILTVKAG EEDYLDTSYL LRQASPYMKI KFDNTEEPCN KRQLKTFPRA
EKNKKIKLSA PKTSQIEENF QGERCQISQE VNLQGKKADP TDRSSPRLEH VAQDKNEREH
IIMRNFSKVL WNVLKQCNEK LKVAEGEIFT LKDSLRREQL KSLGLETELI SLKSSCLAQP
CIPEVEVIVN AKEHFEVDAA LTNERNVDDD SCNLIKARRE AGAEESSETP VPKVVRNVDD
DSCNLIKARR EAGAEESSES PVLSVLRNVD DDSCNLIEAR REAGSEESSK SPVPNVRNVD
VDSCNLINPR REASTEESSE SPVLSKNVKD AELVPCHLSS ENDAEPRQSV NSEENVGIPS
TITHVEAEVT DFQRDQNQDD PTPSPEQVEV SQDCINSGLS NVQTKSAISR RFPDSEKQER
NRRLLPASSR SLTEEMNDLE IKDIQTEKQQ VKTTNTRVQK KAVSIQGQET EVPPREAEPA
STKKQKNGQK PKRRLQPASS VLLTREINTL EIEDDIAEPK VNRGGKKTTV SQPRSQGSVT
LLRLLTNNLH L
