ID   KNAP1_MALDO             Reviewed;         398 AA.
AC   O04134;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Homeobox protein knotted-1-like 1;
DE   AltName: Full=KNAP1;
OS   Malus domestica (Apple) (Pyrus malus).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Maleae; Malus.
OX   NCBI_TaxID=3750;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Wijcik;
RX   PubMed=9132068; DOI=10.1023/a:1005708700636;
RA   Watillon B., Kettmann R., Boxus P., Burny A.;
RT   "Knotted1-like homeobox genes are expressed during apple tree (Malus
RT   domestica [L.] Borkh) growth and development.";
RL   Plant Mol. Biol. 33:757-763(1997).
CC   -!- FUNCTION: Probably binds to the DNA sequence 5'-TGAC-3'.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed only in the stems.
CC   -!- SIMILARITY: Belongs to the TALE/KNOX homeobox family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00559}.
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DR   EMBL; Z71978; CAA96510.1; -; mRNA.
DR   PIR; T17009; T17009.
DR   RefSeq; NP_001298100.1; NM_001311171.1.
DR   AlphaFoldDB; O04134; -.
DR   SMR; O04134; -.
DR   STRING; 3750.XP_008347590.1; -.
DR   EnsemblPlants; mRNA:MD08G0065100; mRNA:MD08G0065100; MD08G0065100.
DR   GeneID; 103410692; -.
DR   Gramene; mRNA:MD08G0065100; mRNA:MD08G0065100; MD08G0065100.
DR   KEGG; mdm:103410692; -.
DR   OrthoDB; 1171537at2759; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR005539; ELK_dom.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR008422; Homeobox_KN_domain.
DR   InterPro; IPR005540; KNOX1.
DR   InterPro; IPR005541; KNOX2.
DR   Pfam; PF03789; ELK; 1.
DR   Pfam; PF05920; Homeobox_KN; 1.
DR   Pfam; PF03790; KNOX1; 1.
DR   Pfam; PF03791; KNOX2; 1.
DR   SMART; SM01188; ELK; 1.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM01255; KNOX1; 1.
DR   SMART; SM01256; KNOX2; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS51213; ELK; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Homeobox; Nucleus.
FT   CHAIN           1..398
FT                   /note="Homeobox protein knotted-1-like 1"
FT                   /id="PRO_0000048975"
FT   DOMAIN          280..300
FT                   /note="ELK"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00559"
FT   DNA_BIND        301..364
FT                   /note="Homeobox; TALE-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          43..69
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          172..192
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          234..277
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        177..192
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   398 AA;  45172 MW;  FB10826235AFDBD3 CRC64;
     MEDYNNQMDH ESSGGRGNFL YASPNLGGNY GRAASDHQMG INTFHLQSSG GGGGGGSGDQ
     CNFQSPGTHP INVKTEATTS QHGHPKFQYN NNNNNHHLVS SSRGHQPVVH QLQHNLDLQN
     DDHSLSSNEV EAIKAKIIAH PQYSNLVEAY MDCQRVGAPS DVVPRLSVAR QEFEARQRSS
     GTSRETSKDP ELDQFMEAYY DMLVKYREEL TRPIQEAMDF MRRIETQLNM LGNNNNAPPL
     RIFSPSEDKC EGIGSSEDEQ ENSGGETEVP EIDPRAEDRE LKNHLLRKYS GYLSSLKQEL
     SKKKKKGKLP KEARQKLLSW WELHYKWPYP SESEKVALAE STGLDQKQIN NWFINQRKRH
     WKPSEDMQFM VMDGLHPQNA ALYMDGHYTG DVHYRLGP