ID   KNAP2_MALDO             Reviewed;         397 AA.
AC   O04135;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Homeobox protein knotted-1-like 2;
DE   AltName: Full=KNAP2;
OS   Malus domestica (Apple) (Pyrus malus).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Maleae; Malus.
OX   NCBI_TaxID=3750;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Wijcik;
RX   PubMed=9132068; DOI=10.1023/a:1005708700636;
RA   Watillon B., Kettmann R., Boxus P., Burny A.;
RT   "Knotted1-like homeobox genes are expressed during apple tree (Malus
RT   domestica [L.] Borkh) growth and development.";
RL   Plant Mol. Biol. 33:757-763(1997).
CC   -!- FUNCTION: Probably binds to the DNA sequence 5'-TGAC-3'.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed only in the stems.
CC   -!- SIMILARITY: Belongs to the TALE/KNOX homeobox family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00559}.
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DR   EMBL; Z71979; CAA96511.1; -; mRNA.
DR   PIR; T17008; T17008.
DR   AlphaFoldDB; O04135; -.
DR   SMR; O04135; -.
DR   STRING; 3750.XP_008360967.1; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR005539; ELK_dom.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR008422; Homeobox_KN_domain.
DR   InterPro; IPR005540; KNOX1.
DR   InterPro; IPR005541; KNOX2.
DR   Pfam; PF03789; ELK; 1.
DR   Pfam; PF05920; Homeobox_KN; 1.
DR   Pfam; PF03790; KNOX1; 1.
DR   Pfam; PF03791; KNOX2; 1.
DR   SMART; SM01188; ELK; 1.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM01255; KNOX1; 1.
DR   SMART; SM01256; KNOX2; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS51213; ELK; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Homeobox; Nucleus.
FT   CHAIN           1..397
FT                   /note="Homeobox protein knotted-1-like 2"
FT                   /id="PRO_0000048976"
FT   DOMAIN          279..299
FT                   /note="ELK"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00559"
FT   DNA_BIND        300..363
FT                   /note="Homeobox; TALE-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          43..68
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          172..191
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          233..276
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        176..191
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   397 AA;  45007 MW;  FDBD106E385B8935 CRC64;
     MEDYNNQMDH ESSGGRGNFL YASPNLGGNY GRAASDHQMG INTFHLQSSG GGGGGGSGDQ
     CNFQSPGTHP INVKTEATTS QHGHQKFQYN NNNNSHLVSS SRGHQPVIHQ LQNNFDLLND
     DHSLSSNEVE AIKAKIIAHP QYSNLLEAYM DCQRVGAPSD VVARLSVARQ EFEARQRSSG
     TSRETSKDPE LDQFMEAYYD MLVKYREELT RPIQEAMDFM RRIETQLNML GNNNNAPPLR
     IFSPSEDKCE GIGSSEEEQE NSGGETEVPE IDPRAEDREL KNHLLRKYSG YLSSLKQELS
     KKKKKGKLPK DARQKLLSWW ELHYKWPYPS ESEKVALAES TGLDQKQINN WFINQRKRHW
     KPSEDMQFMV MDGLHPQNAA LYMDGHYIGD GHYRLGP