ID   KNAP3_MALDO             Reviewed;         427 AA.
AC   O04136;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Homeobox protein knotted-1-like 3;
DE   AltName: Full=KNAP3;
OS   Malus domestica (Apple) (Pyrus malus).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Maleae; Malus.
OX   NCBI_TaxID=3750;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Wijcik;
RX   PubMed=9132068; DOI=10.1023/a:1005708700636;
RA   Watillon B., Kettmann R., Boxus P., Burny A.;
RT   "Knotted1-like homeobox genes are expressed during apple tree (Malus
RT   domestica [L.] Borkh) growth and development.";
RL   Plant Mol. Biol. 33:757-763(1997).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Maximally expressed in sepals, petals and fully
CC       expanded leaves. Also expressed in other flower organs and in
CC       developing leaves. Low level expression in stem internodes.
CC   -!- SIMILARITY: Belongs to the TALE/KNOX homeobox family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00559}.
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DR   EMBL; Z71980; CAA96512.1; -; mRNA.
DR   PIR; T17010; T17010.
DR   AlphaFoldDB; O04136; -.
DR   SMR; O04136; -.
DR   STRING; 3750.XP_008378414.1; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR005539; ELK_dom.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR008422; Homeobox_KN_domain.
DR   InterPro; IPR005540; KNOX1.
DR   InterPro; IPR005541; KNOX2.
DR   Pfam; PF03789; ELK; 1.
DR   Pfam; PF05920; Homeobox_KN; 1.
DR   Pfam; PF03790; KNOX1; 1.
DR   Pfam; PF03791; KNOX2; 1.
DR   SMART; SM01188; ELK; 1.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM01255; KNOX1; 1.
DR   SMART; SM01256; KNOX2; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS51213; ELK; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Homeobox; Nucleus.
FT   CHAIN           1..427
FT                   /note="Homeobox protein knotted-1-like 3"
FT                   /id="PRO_0000048977"
FT   DOMAIN          330..350
FT                   /note="ELK"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00559"
FT   DNA_BIND        351..414
FT                   /note="Homeobox; TALE-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          19..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          272..291
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   427 AA;  47933 MW;  4B5171B3EC50A210 CRC64;
     MAYHNHLSQD LPLHHFTDQT HHQHQQYQSD QPDPNSKPPE PHHSFQPAPN WLNSALLRNF
     TNTDTNPTNS NNANNNGGGV SNFLNLHVTA SDSAASQASN QWLSQSHRPI LHRNHSDVND
     DVTVAGDSMI AAALSHDSAD LKPDSILNKN EGGGGDGGVM NWQNARHKAE ILAHPLYEPL
     LSAHVACLRI ATPVDQLPRI DAQLAQSQNV VAKYSALGNG MVGDDKELDQ FMRNYVLLLC
     SFKEQLQQHV RVHAMEAVMA CWEIEQSLQS LTGVSPGEGT SATMSDDEDD QVDSDANLFD
     EGMEGHDSMG FGPLIPTESE RSLMERVRQE LKHELKQGYK EKIVDIREEI LRKRRAGKLP
     GDTTSVLKAW WQSHSKWPYP TEEDKARLVQ ETGLQLKQIN NWFINQRKRN WHSNPSTSTV
     LKSKRKR