KNAT3_ARATH
ID KNAT3_ARATH Reviewed; 431 AA.
AC P48000; Q8L839; Q8LDC1;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=Homeobox protein knotted-1-like 3;
DE AltName: Full=Protein KNAT3;
GN Name=KNAT3; OrderedLocusNames=At5g25220; ORFNames=F21J6.18;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9161040; DOI=10.1046/j.1365-313x.1997.11040853.x;
RA Serikawa K.A., Martinez-Laborda A., Kim H.S., Zambryski P.C.;
RT "Localization of expression of KNAT3, a class 2 knotted1-like gene.";
RL Plant J. 11:853-861(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 17-431 AND 126-431.
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [6]
RP INTERACTION WITH OFP1; OFP2; OFP4; OFP12 AND OFP14.
RX PubMed=15781858; DOI=10.1073/pnas.0501181102;
RA Hackbusch J., Richter K., Muller J., Salamini F., Uhrig J.F.;
RT "A central role of Arabidopsis thaliana ovate family proteins in networking
RT and subcellular localization of 3-aa loop extension homeodomain proteins.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:4908-4912(2005).
RN [7]
RP INTERACTION WITH KNATM.
RX PubMed=18398054; DOI=10.1105/tpc.108.058495;
RA Magnani E., Hake S.;
RT "KNOX lost the OX: the Arabidopsis KNATM gene defines a novel class of KNOX
RT transcriptional regulators missing the homeodomain.";
RL Plant Cell 20:875-887(2008).
CC -!- SUBUNIT: May form heterodimeric complex with the TALE/BELL proteins (By
CC similarity). Interacts with OFP1, OFP2, OFP4, OFP12 and OFP14
CC (PubMed:15781858). Interacts with KNATM-B (PubMed:18398054).
CC {ECO:0000250, ECO:0000269|PubMed:15781858,
CC ECO:0000269|PubMed:18398054}.
CC -!- INTERACTION:
CC P48000; Q38897: BEL1; NbExp=3; IntAct=EBI-1153908, EBI-1153783;
CC P48000; Q9FWS9: BLH3; NbExp=3; IntAct=EBI-1153908, EBI-912915;
CC P48000; Q8S897: BLH5; NbExp=3; IntAct=EBI-1153908, EBI-1153992;
CC P48000; Q9SIW1: BLH7; NbExp=3; IntAct=EBI-1153908, EBI-1153967;
CC P48000; Q9LQT8: GAI; NbExp=3; IntAct=EBI-1153908, EBI-963606;
CC P48000; Q8GXW1: RGL2; NbExp=3; IntAct=EBI-1153908, EBI-963665;
CC P48000; Q9LQF0: TCP23; NbExp=3; IntAct=EBI-1153908, EBI-15192297;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=P48000-1; Sequence=Displayed;
CC -!- SIMILARITY: Belongs to the TALE/KNOX homeobox family.
CC {ECO:0000255|PROSITE-ProRule:PRU00559}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM53320.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; X92392; CAA63130.1; -; mRNA.
DR EMBL; AC006259; AAC98441.1; -; Genomic_DNA.
DR EMBL; CP002688; AED93413.1; -; Genomic_DNA.
DR EMBL; AY086091; AAM63298.1; -; mRNA.
DR EMBL; AY120762; AAM53320.1; ALT_INIT; mRNA.
DR EMBL; BT000139; AAN15458.1; -; mRNA.
DR RefSeq; NP_197904.1; NM_122431.3. [P48000-1]
DR AlphaFoldDB; P48000; -.
DR SMR; P48000; -.
DR BioGRID; 17868; 66.
DR IntAct; P48000; 58.
DR STRING; 3702.AT5G25220.1; -.
DR iPTMnet; P48000; -.
DR PaxDb; P48000; -.
DR PRIDE; P48000; -.
DR ProteomicsDB; 237092; -. [P48000-1]
DR EnsemblPlants; AT5G25220.1; AT5G25220.1; AT5G25220. [P48000-1]
DR GeneID; 832593; -.
DR Gramene; AT5G25220.1; AT5G25220.1; AT5G25220. [P48000-1]
DR KEGG; ath:AT5G25220; -.
DR Araport; AT5G25220; -.
DR TAIR; locus:2146945; AT5G25220.
DR eggNOG; KOG0773; Eukaryota.
DR InParanoid; P48000; -.
DR PhylomeDB; P48000; -.
DR PRO; PR:P48000; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; P48000; baseline and differential.
DR Genevisible; P48000; AT.
DR GO; GO:0005829; C:cytosol; IDA:TAIR.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0071345; P:cellular response to cytokine stimulus; IDA:TAIR.
DR GO; GO:0009722; P:detection of cytokinin stimulus; IEP:TAIR.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0009416; P:response to light stimulus; IEP:TAIR.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR005539; ELK_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR InterPro; IPR005540; KNOX1.
DR InterPro; IPR005541; KNOX2.
DR Pfam; PF03789; ELK; 1.
DR Pfam; PF05920; Homeobox_KN; 1.
DR Pfam; PF03790; KNOX1; 1.
DR Pfam; PF03791; KNOX2; 1.
DR SMART; SM01188; ELK; 1.
DR SMART; SM00389; HOX; 1.
DR SMART; SM01255; KNOX1; 1.
DR SMART; SM01256; KNOX2; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51213; ELK; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..431
FT /note="Homeobox protein knotted-1-like 3"
FT /id="PRO_0000048959"
FT DOMAIN 322..342
FT /note="ELK"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00559"
FT DNA_BIND 343..406
FT /note="Homeobox; TALE-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 15..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 402..431
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..39
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 402..419
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 96
FT /note="R -> L (in Ref. 4; AAM63298)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 431 AA; 47600 MW; 5222B67AB54B9673 CRC64;
MAFHHNHLSQ DLSFNHFTDQ HQPPPPQPPP PPPQQQQHFQ EAPPPNWLNT ALLRSSDNNN
NFLNLHTATA NTTTASSSDS PSSAAAAAAA NQWLSRSSSF LQRNNNNNAS IVGDGIDDVT
GGADTMIQGE MKTGGGENKN DGGGATAADG VVSWQNARHK AEILSHPLYE QLLSAHVACL
RIATPVDQLP RIDAQLAQSQ HVVAKYSALG AAAQGLVGDD KELDQFMTHY VLLLCSFKEQ
LQQHVRVHAM EAVMACWEIE QSLQSLTGVS PGEGMGATMS DDEDEQVESD ANMFDGGLDV
LGFGPLIPTE SERSLMERVR QELKHELKQG YKEKIVDIRE EILRKRRAGK LPGDTTSVLK
AWWQSHSKWP YPTEEDKARL VQETGLQLKQ INNWFINQRK RNWHSNPSSS TVLKNKRKSN
AGDNSGRERF A
