KNAT4_ARATH
ID KNAT4_ARATH Reviewed; 393 AA.
AC P48001; Q8GXD4; Q9FY59;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2005, sequence version 3.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Homeobox protein knotted-1-like 4;
DE AltName: Full=Protein KNAT4;
GN Name=KNAT4; OrderedLocusNames=At5g11060; ORFNames=T5K6_50;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8980519; DOI=10.1007/bf00020208;
RA Serikawa K.A., Martinez-Laborda A., Zambryski P.C.;
RT "Three knotted1-like homeobox genes in Arabidopsis.";
RL Plant Mol. Biol. 32:673-683(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [5]
RP INTERACTION WITH OFP1; OFP2; OFP4 AND OFP12.
RX PubMed=15781858; DOI=10.1073/pnas.0501181102;
RA Hackbusch J., Richter K., Muller J., Salamini F., Uhrig J.F.;
RT "A central role of Arabidopsis thaliana ovate family proteins in networking
RT and subcellular localization of 3-aa loop extension homeodomain proteins.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:4908-4912(2005).
RN [6]
RP INTERACTION WITH KNATM.
RX PubMed=18398054; DOI=10.1105/tpc.108.058495;
RA Magnani E., Hake S.;
RT "KNOX lost the OX: the Arabidopsis KNATM gene defines a novel class of KNOX
RT transcriptional regulators missing the homeodomain.";
RL Plant Cell 20:875-887(2008).
CC -!- SUBUNIT: May form heterodimeric complex with the TALE/BELL proteins (By
CC similarity). Interacts with OFP1, OFP2, OFP4 and OFP12
CC (PubMed:15781858). Interacts with KNATM-B (PubMed:18398054).
CC {ECO:0000250, ECO:0000269|PubMed:15781858,
CC ECO:0000269|PubMed:18398054}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TALE/KNOX homeobox family.
CC {ECO:0000255|PROSITE-ProRule:PRU00559}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAC03454.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; X92393; CAA63131.1; -; mRNA.
DR EMBL; AL391222; CAC03454.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED91630.1; -; Genomic_DNA.
DR EMBL; AK118296; BAC42914.1; -; mRNA.
DR PIR; T51795; T51795.
DR RefSeq; NP_196667.2; NM_121144.4.
DR AlphaFoldDB; P48001; -.
DR SMR; P48001; -.
DR BioGRID; 16251; 12.
DR IntAct; P48001; 11.
DR STRING; 3702.AT5G11060.1; -.
DR iPTMnet; P48001; -.
DR PaxDb; P48001; -.
DR PRIDE; P48001; -.
DR ProteomicsDB; 250695; -.
DR EnsemblPlants; AT5G11060.1; AT5G11060.1; AT5G11060.
DR GeneID; 830973; -.
DR Gramene; AT5G11060.1; AT5G11060.1; AT5G11060.
DR KEGG; ath:AT5G11060; -.
DR Araport; AT5G11060; -.
DR TAIR; locus:2184911; AT5G11060.
DR eggNOG; KOG0773; Eukaryota.
DR HOGENOM; CLU_040111_1_0_1; -.
DR InParanoid; P48001; -.
DR OMA; LRTQTHA; -.
DR OrthoDB; 1070344at2759; -.
DR PhylomeDB; P48001; -.
DR PRO; PR:P48001; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; P48001; baseline and differential.
DR Genevisible; P48001; AT.
DR GO; GO:0005829; C:cytosol; IDA:TAIR.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0009416; P:response to light stimulus; IEP:TAIR.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR005539; ELK_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR InterPro; IPR005540; KNOX1.
DR InterPro; IPR005541; KNOX2.
DR Pfam; PF03789; ELK; 1.
DR Pfam; PF05920; Homeobox_KN; 1.
DR Pfam; PF03790; KNOX1; 1.
DR Pfam; PF03791; KNOX2; 1.
DR SMART; SM01188; ELK; 1.
DR SMART; SM00389; HOX; 1.
DR SMART; SM01255; KNOX1; 1.
DR SMART; SM01256; KNOX2; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51213; ELK; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..393
FT /note="Homeobox protein knotted-1-like 4"
FT /id="PRO_0000048960"
FT DOMAIN 286..306
FT /note="ELK"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00559"
FT DNA_BIND 307..370
FT /note="Homeobox; TALE-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 81..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 363..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..96
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 363..383
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 55
FT /note="S -> T (in Ref. 1; CAA63131)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 393 AA; 44385 MW; B9CBF445A8405C3F CRC64;
MAFHNNHFNH FTDQQQHQPP PPPQQQQQQH FQESAPPNWL LRSDNNFLNL HTAASAAATS
SDSPSSAAAN QWLSRSSSFL QRGNTANNNN NETSGDVIED VPGGEESMIG EKKEAERWQN
ARHKAEILSH PLYEQLLSAH VACLRIATPV DQLPRIDAQL AQSQNVVAKY STLEAAQGLL
AGDDKELDHF MTHYVLLLCS FKEQLQQHVR VHAMEAVMAC WEIEQSLQSF TGVSPGEGTG
ATMSEDEDEQ VESDAHLFDG SLDGLGFGPL VPTESERSLM ERVRQELKHE LKQGYKEKIV
DIREEILRKR RAGKLPGDTT SVLKSWWQSH SKWPYPTEED KARLVQETGL QLKQINNWFI
NQRKRNWHSN PSSSTVSKNK RRSNAGENSG RDR
