KNATM_ARATH
ID KNATM_ARATH Reviewed; 142 AA.
AC F4HXU3; F4HXU1; F4HXU2; Q9LQV5;
DT 14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 64.
DE RecName: Full=Protein KNATM {ECO:0000303|PubMed:18398054};
DE AltName: Full=KNOX Arabidopsis thaliana MEINOX protein {ECO:0000303|PubMed:18398054};
GN Name=KNATM {ECO:0000303|PubMed:18398054};
GN OrderedLocusNames=At1g14760 {ECO:0000312|Araport:AT1G14760};
GN ORFNames=F10B6.16 {ECO:0000312|EMBL:AAF79243.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP FUNCTION (ISOFORM KNATM-B), ALTERNATIVE SPLICING, TISSUE SPECIFICITY,
RP INTERACTION WITH KNAT1; KNAT3; KNAT4; BEL1; BLH2; BLH4 AND BLH9 (ISOFORM
RP KNATM-B), DOMAIN (ISOFORM KNATM-B), AND SUBCELLULAR LOCATION (ISOFORM
RP KNATM-B).
RX PubMed=18398054; DOI=10.1105/tpc.108.058495;
RA Magnani E., Hake S.;
RT "KNOX lost the OX: the Arabidopsis KNATM gene defines a novel class of KNOX
RT transcriptional regulators missing the homeodomain.";
RL Plant Cell 20:875-887(2008).
RN [4]
RP INDUCTION BY THE AS1 REPRESSOR COMPLEX.
RX PubMed=23271976; DOI=10.1371/journal.pgen.1003114;
RA Luo M., Yu C.W., Chen F.F., Zhao L., Tian G., Liu X., Cui Y., Yang J.Y.,
RA Wu K.;
RT "Histone deacetylase HDA6 is functionally associated with AS1 in repression
RT of KNOX genes in arabidopsis.";
RL PLoS Genet. 8:E1003114-E1003114(2012).
CC -!- FUNCTION: [Isoform KNATM-B]: Transcriptional regulator involved in leaf
CC proximal/distal patterning. May act by sequestering BELL transcription
CC factors. {ECO:0000269|PubMed:18398054}.
CC -!- SUBUNIT: [Isoform KNATM-B]: Interacts with KNAT1, KNAT3, KNAT4, BEL1,
CC BLH2, BLH4 and BLH9, but not with BLH8 or the KNATM-A and KNATM-C
CC isoforms. Isoforms KNATM-A and KNATM-C: no interactions with KNATM-B,
CC KNOXX or BELL proteins. {ECO:0000269|PubMed:18398054}.
CC -!- SUBCELLULAR LOCATION: [Isoform KNATM-B]: Cytoplasm
CC {ECO:0000269|PubMed:18398054}. Nucleus {ECO:0000269|PubMed:18398054}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=KNATM-A {ECO:0000303|PubMed:18398054};
CC IsoId=F4HXU3-1; Sequence=Displayed;
CC Name=KNATM-B {ECO:0000303|PubMed:18398054};
CC IsoId=F4HXU3-2; Sequence=VSP_057901;
CC Name=KNATM-C {ECO:0000303|PubMed:18398054};
CC IsoId=F4HXU3-3; Sequence=VSP_057899, VSP_057900;
CC -!- TISSUE SPECIFICITY: Detected in inflorescences, seedlings, leaves,
CC hydathodes, stems, roots, embryo and siliques. Expressed in a polar
CC pattern in organ primordia and at the boundary of mature organs.
CC Detected in the lateral domains of flower meristems, but not in the
CC inflorescence meristem or the vegetative shoot apical meristem.
CC {ECO:0000269|PubMed:18398054}.
CC -!- INDUCTION: Down-regulated by the AS1 repressor complex including HDA6.
CC {ECO:0000269|PubMed:23271976}.
CC -!- DOMAIN: [Isoform KNATM-B]: The MEINOX domain (33-138) is sufficient for
CC interactions with BELL proteins (PubMed:18398054). The BP-interacting
CC domain (BPID, 1-32) is necessary for interactions with KNOX proteins
CC (PubMed:18398054). {ECO:0000269|PubMed:18398054}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF79243.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC006917; AAF79243.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE29220.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE29221.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE29222.1; -; Genomic_DNA.
DR PIR; G86281; G86281.
DR RefSeq; NP_001154340.1; NM_001160868.2. [F4HXU3-2]
DR RefSeq; NP_001154341.1; NM_001160869.1. [F4HXU3-3]
DR RefSeq; NP_172929.1; NM_101345.2. [F4HXU3-1]
DR AlphaFoldDB; F4HXU3; -.
DR STRING; 3702.AT1G14760.1; -.
DR PaxDb; F4HXU3; -.
DR PRIDE; F4HXU3; -.
DR EnsemblPlants; AT1G14760.1; AT1G14760.1; AT1G14760. [F4HXU3-1]
DR EnsemblPlants; AT1G14760.2; AT1G14760.2; AT1G14760. [F4HXU3-2]
DR EnsemblPlants; AT1G14760.3; AT1G14760.3; AT1G14760. [F4HXU3-3]
DR GeneID; 838041; -.
DR Gramene; AT1G14760.1; AT1G14760.1; AT1G14760. [F4HXU3-1]
DR Gramene; AT1G14760.2; AT1G14760.2; AT1G14760. [F4HXU3-2]
DR Gramene; AT1G14760.3; AT1G14760.3; AT1G14760. [F4HXU3-3]
DR KEGG; ath:AT1G14760; -.
DR Araport; AT1G14760; -.
DR TAIR; locus:2006782; AT1G14760.
DR eggNOG; ENOG502S8VX; Eukaryota.
DR HOGENOM; CLU_1818457_0_0_1; -.
DR InParanoid; F4HXU3; -.
DR OMA; ENHINCL; -.
DR OrthoDB; 1471541at2759; -.
DR PRO; PR:F4HXU3; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; F4HXU3; baseline and differential.
DR Genevisible; F4HXU3; AT.
DR GO; GO:0005737; C:cytoplasm; IDA:TAIR.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0010589; P:leaf proximal/distal pattern formation; IMP:TAIR.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:TAIR.
DR InterPro; IPR005540; KNOX1.
DR Pfam; PF03790; KNOX1; 1.
DR SMART; SM01255; KNOX1; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Cytoplasm; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..142
FT /note="Protein KNATM"
FT /id="PRO_0000434107"
FT COILED 4..36
FT /evidence="ECO:0000255"
FT VAR_SEQ 56..96
FT /note="VCSGDFDSPEIMNTADDLALSKLSLHPDSSSEATSSELDQF -> EAYCSTL
FT RELKEAMEKPLTETHRFVDAVYTQLNDIVMSSPP (in isoform KNATM-C)"
FT /id="VSP_057899"
FT VAR_SEQ 97..142
FT /note="Missing (in isoform KNATM-C)"
FT /id="VSP_057900"
FT VAR_SEQ 98..142
FT /note="VLFFFSPCQNIFTQQKTTFHVLLFFPLQINLTFKYSKFILPRKKQ -> EAY
FT CSTLRELKEAMEKPLTETHRFVDAVYTQLNDIVMSSPP (in isoform KNATM-
FT B)"
FT /id="VSP_057901"
SQ SEQUENCE 142 AA; 16439 MW; 0FCB037BFCA09EE7 CRC64;
MDVKKDENSI LENMKQEINH SLKEEAQEEE EILKKRISSH PLYGLLLHSH LNCLKVCSGD
FDSPEIMNTA DDLALSKLSL HPDSSSEATS SELDQFMVLF FFSPCQNIFT QQKTTFHVLL
FFPLQINLTF KYSKFILPRK KQ
