KNCN_MOUSE
ID KNCN_MOUSE Reviewed; 124 AA.
AC Q307W7;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Kinocilin;
GN Name=Kncn; Synonyms=Kino;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=129/Sv;
RX PubMed=15855039; DOI=10.1016/j.heares.2004.12.002;
RA Leibovici M., Verpy E., Goodyear R.J., Zwaenepoel I., Blanchard S.,
RA Laine S., Richardson G.P., Petit C.;
RT "Initial characterization of kinocilin, a protein of the hair cell
RT kinocilium.";
RL Hear. Res. 203:144-153(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play a role in stabilizing dense microtubular networks or
CC in vesicular trafficking.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Preferentially expressed in the inner ear and
CC testis. Localizes mainly in the kinocilium of sensory cells in the
CC inner ear. Also present in the manchette of the spermatids, a transient
CC structure enriched in interconnected microtubules (at protein level).
CC -!- DEVELOPMENTAL STAGE: First detected in the kinocilia of vestibular and
CC auditory hair cells at embryonic days 14.5, and 18.5, respectively. In
CC the mature vestibular hair cells, it is still present in the
CC kinocilium. As the auditory hair cells begin to lose the kinocilium
CC during postnatal development, it becomes distributed in an annular
CC pattern at the apex of these cells, where it colocalizes with the
CC tubulin belt. In mature auditory hair cells, it is also present at the
CC level of the cuticular plate, at the base of each stereocilium. As the
CC kinocilium regresses from developing auditory hair cells, it begins to
CC be expressed by the pillar cells and Deiters cells, that both contain
CC prominent transcellular and apical bundles of microtubules. Not
CC detected in the supporting cells in the vestibular end organs (at
CC protein level).
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DR EMBL; DQ235452; ABB48425.1; -; mRNA.
DR EMBL; AL627085; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC132034; AAI32035.1; -; mRNA.
DR EMBL; BC132036; AAI32037.1; -; mRNA.
DR CCDS; CCDS18499.1; -.
DR RefSeq; NP_001034213.1; NM_001039124.4.
DR AlphaFoldDB; Q307W7; -.
DR STRING; 10090.ENSMUSP00000095531; -.
DR PhosphoSitePlus; Q307W7; -.
DR PaxDb; Q307W7; -.
DR PRIDE; Q307W7; -.
DR Antibodypedia; 51691; 13 antibodies from 7 providers.
DR Ensembl; ENSMUST00000097918; ENSMUSP00000095531; ENSMUSG00000073774.
DR GeneID; 654462; -.
DR KEGG; mmu:654462; -.
DR UCSC; uc008ufo.1; mouse.
DR CTD; 148930; -.
DR MGI; MGI:3614952; Kncn.
DR VEuPathDB; HostDB:ENSMUSG00000073774; -.
DR eggNOG; ENOG502S6ED; Eukaryota.
DR GeneTree; ENSGT00400000024146; -.
DR HOGENOM; CLU_2090155_0_0_1; -.
DR InParanoid; Q307W7; -.
DR OMA; RIHPNPG; -.
DR TreeFam; TF354182; -.
DR BioGRID-ORCS; 654462; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Kncn; mouse.
DR PRO; PR:Q307W7; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q307W7; protein.
DR Bgee; ENSMUSG00000073774; Expressed in ectoplacental cone and 6 other tissues.
DR GO; GO:0045177; C:apical part of cell; IDA:MGI.
DR GO; GO:0016324; C:apical plasma membrane; IDA:MGI.
DR GO; GO:0036064; C:ciliary basal body; IDA:MGI.
DR GO; GO:0032437; C:cuticular plate; IDA:MGI.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0060091; C:kinocilium; IDA:MGI.
DR GO; GO:0015630; C:microtubule cytoskeleton; IDA:MGI.
DR GO; GO:0043025; C:neuronal cell body; IDA:MGI.
DR InterPro; IPR027837; Kinocilin.
DR PANTHER; PTHR38497; PTHR38497; 1.
DR Pfam; PF15033; Kinocilin; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..124
FT /note="Kinocilin"
FT /id="PRO_0000311266"
FT TRANSMEM 13..33
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 80..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..109
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 124 AA; 12809 MW; 103DBBBDDDB98B5F CRC64;
MDIPISTRDF RCLQLACVAL GLVAGSIIIG VSVSKAAAAV GGIFLGAAGL GLLIFAYPFL
KARFNLDHIL PAIGNLRIHP NSGPDHGEGR SSNNSNKEGA RSGLSTVTRT LEKLKPGGRG
TEEG
