KNDC1_HUMAN
ID KNDC1_HUMAN Reviewed; 1749 AA.
AC Q76NI1; B0QZC5; Q5T233; Q6ZNH8; Q8TEE5; Q96LV7; Q9C095;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 2.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Kinase non-catalytic C-lobe domain-containing protein 1 {ECO:0000312|HGNC:HGNC:29374};
DE Short=KIND domain-containing protein 1 {ECO:0000303|PubMed:24788352};
DE AltName: Full=Cerebral protein 9 {ECO:0000303|Ref.3};
DE AltName: Full=Protein very KIND {ECO:0000250|UniProtKB:Q0KK55};
DE Short=v-KIND {ECO:0000250|UniProtKB:Q0KK55};
DE AltName: Full=Ras-GEF domain-containing family member 2 {ECO:0000312|HGNC:HGNC:29374};
GN Name=KNDC1 {ECO:0000312|HGNC:HGNC:29374};
GN Synonyms=C10orf23, KIAA1768, RASGEF2, VKIND {ECO:0000250|UniProtKB:Q0KK55};
GN ORFNames=hucep-9 {ECO:0000303|Ref.3};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 35-1193 (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=11214970; DOI=10.1093/dnares/7.6.347;
RA Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XIX. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:347-355(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 36-1749 (ISOFORM 1), TISSUE SPECIFICITY, AND
RP VARIANTS GLY-436 AND PRO-717.
RC TISSUE=Brain cortex;
RA Yoshimoto M., Yazaki M., Matsumoto K., Takayama K.;
RT "Molecular cloning of a novel gene which is specifically expressed in human
RT cerebral cortex.";
RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 579-1749 (ISOFORM 2).
RC TISSUE=Spleen;
RA Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.;
RT "The nucleotide sequence of a long cDNA clone isolated from human spleen.";
RL Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1241-1749 (ISOFORM 1).
RC TISSUE=Brain, and Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP FUNCTION.
RX PubMed=24788352; DOI=10.3892/mmr.2014.2201;
RA Zhang C., Zhen Y.Z., Lin Y.J., Liu J., Wei J., Xu R., Hu G.;
RT "KNDC1 knockdown protects human umbilical vein endothelial cells from
RT senescence.";
RL Mol. Med. Report. 10:82-88(2014).
CC -!- FUNCTION: RAS-Guanine nucleotide exchange factor (GEF) that controls
CC the negative regulation of neuronal dendrite growth by mediating a
CC signaling pathway linking RAS and MAP2 (By similarity). May be involved
CC in cellular senescence (PubMed:24788352).
CC {ECO:0000250|UniProtKB:Q0KK55, ECO:0000269|PubMed:24788352}.
CC -!- SUBUNIT: Interacts (via KIND2) with MAP2; the interaction enhances MAP2
CC phosphorylation and localizes KNDC1 to dendrites.
CC {ECO:0000250|UniProtKB:Q0KK55}.
CC -!- SUBCELLULAR LOCATION: Cell projection, dendrite
CC {ECO:0000250|UniProtKB:Q0KK55}. Perikaryon
CC {ECO:0000250|UniProtKB:Q0KK55}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q76NI1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q76NI1-4; Sequence=VSP_028595, VSP_028598;
CC -!- TISSUE SPECIFICITY: Expressed specifically in the cerebral cortex.
CC {ECO:0000269|Ref.3}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB21859.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
CC Sequence=BAB71561.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAD12625.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAD18397.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AL445199; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AB051555; BAB21859.1; ALT_SEQ; mRNA.
DR EMBL; AB000781; BAD12625.1; ALT_INIT; mRNA.
DR EMBL; AK074179; BAB85005.1; -; mRNA.
DR EMBL; AK057756; BAB71561.1; ALT_INIT; mRNA.
DR EMBL; AK131205; BAD18397.1; ALT_INIT; mRNA.
DR CCDS; CCDS7674.1; -. [Q76NI1-1]
DR RefSeq; NP_689856.6; NM_152643.7. [Q76NI1-1]
DR AlphaFoldDB; Q76NI1; -.
DR BioGRID; 124529; 26.
DR IntAct; Q76NI1; 7.
DR MINT; Q76NI1; -.
DR STRING; 9606.ENSP00000304437; -.
DR iPTMnet; Q76NI1; -.
DR PhosphoSitePlus; Q76NI1; -.
DR BioMuta; KNDC1; -.
DR DMDM; 160013711; -.
DR EPD; Q76NI1; -.
DR jPOST; Q76NI1; -.
DR MassIVE; Q76NI1; -.
DR PaxDb; Q76NI1; -.
DR PeptideAtlas; Q76NI1; -.
DR PRIDE; Q76NI1; -.
DR ProteomicsDB; 68693; -. [Q76NI1-1]
DR ProteomicsDB; 68696; -. [Q76NI1-4]
DR Antibodypedia; 48672; 62 antibodies from 12 providers.
DR DNASU; 85442; -.
DR Ensembl; ENST00000304613.8; ENSP00000304437.3; ENSG00000171798.19. [Q76NI1-1]
DR Ensembl; ENST00000368571.3; ENSP00000357560.3; ENSG00000171798.19. [Q76NI1-4]
DR GeneID; 85442; -.
DR KEGG; hsa:85442; -.
DR MANE-Select; ENST00000304613.8; ENSP00000304437.3; NM_152643.8; NP_689856.6.
DR UCSC; uc001llz.2; human. [Q76NI1-1]
DR CTD; 85442; -.
DR GeneCards; KNDC1; -.
DR HGNC; HGNC:29374; KNDC1.
DR HPA; ENSG00000171798; Tissue enhanced (brain, pituitary gland).
DR MIM; 616237; gene.
DR neXtProt; NX_Q76NI1; -.
DR OpenTargets; ENSG00000171798; -.
DR PharmGKB; PA134983621; -.
DR VEuPathDB; HostDB:ENSG00000171798; -.
DR eggNOG; ENOG502QSHW; Eukaryota.
DR GeneTree; ENSGT00390000011408; -.
DR HOGENOM; CLU_003380_0_0_1; -.
DR InParanoid; Q76NI1; -.
DR OMA; YWDEQLL; -.
DR OrthoDB; 78094at2759; -.
DR PhylomeDB; Q76NI1; -.
DR TreeFam; TF336009; -.
DR PathwayCommons; Q76NI1; -.
DR SignaLink; Q76NI1; -.
DR BioGRID-ORCS; 85442; 11 hits in 1064 CRISPR screens.
DR ChiTaRS; KNDC1; human.
DR GenomeRNAi; 85442; -.
DR Pharos; Q76NI1; Tdark.
DR PRO; PR:Q76NI1; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q76NI1; protein.
DR Bgee; ENSG00000171798; Expressed in right hemisphere of cerebellum and 139 other tissues.
DR Genevisible; Q76NI1; HS.
DR GO; GO:0030425; C:dendrite; ISS:UniProtKB.
DR GO; GO:0032045; C:guanyl-nucleotide exchange factor complex; ISS:UniProtKB.
DR GO; GO:0043025; C:neuronal cell body; ISS:UniProtKB.
DR GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0021707; P:cerebellar granule cell differentiation; ISS:UniProtKB.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; ISS:UniProtKB.
DR GO; GO:0050773; P:regulation of dendrite development; ISS:UniProtKB.
DR GO; GO:0048814; P:regulation of dendrite morphogenesis; ISS:UniProtKB.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; -; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR011019; KIND_dom.
DR InterPro; IPR029899; KNDC1.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR21560; PTHR21560; 1.
DR Pfam; PF16474; KIND; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00750; KIND; 2.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; SSF48366; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS51377; KIND; 2.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell projection; Coiled coil;
KW Guanine-nucleotide releasing factor; Phosphoprotein; Reference proteome;
KW Repeat.
FT CHAIN 1..1749
FT /note="Kinase non-catalytic C-lobe domain-containing
FT protein 1"
FT /id="PRO_0000307141"
FT DOMAIN 37..217
FT /note="KIND 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00709"
FT DOMAIN 444..608
FT /note="KIND 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00709"
FT DOMAIN 1246..1371
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00135"
FT DOMAIN 1468..1719
FT /note="Ras-GEF"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00168"
FT REGION 210..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 361..435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 689..871
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 962..1061
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1133..1190
FT /evidence="ECO:0000255"
FT COMPBIAS 223..240
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..271
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..432
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 695..717
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 962..989
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1008..1023
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1045..1059
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 964
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q0KK55"
FT VAR_SEQ 1130..1396
FT /note="ELEQQLMMEKRNYRKTLKFYQKLLQKEKRNKGSDVKTMLSKLKGQLEEMKSR
FT VQFLSLVKKYLQVMYAERWGLEPCTLPVIVNIAAAPCDTLDFSPLDESSSLIFYNVNKH
FT PGGRQKARILQAGTPLGLMAYLYSSDAFLEGYVQQFLYTFRYFCTPHDFLHFLLDRINS
FT TLTRAHQDPTSTFTKIYRRSLCVLQAWVEDCYAVDFPRNSGLLGKLEDFISSKILPLDG
FT SAKHLLGLLEVGMDRRAEGNPRGTDLENPREAEEDARP -> VSPRPWHCRVGQGVSFQ
FT QSFLVTAGDRWHRVPRAPNRVTLVLVPPPRGCQDGQGPLPGLSSTSRDRLVCTGAPGGS
FT TSEDREGLFSHGRPGDGFTGGPSMLVTRLRSVVFSVGQAQPPGPWAASLCSERKHQKRL
FT PSKSRLGLVAAAWSGLSGQQCHPGSGAAATPPWPAGRGGLRPGSPGCRRGLQSSGRKVG
FT PVTHSPDLGCILESPGTPGWMTGGAQWPSAPGTSPTTVCLELSHRGKPPPASGHRSPSW
FT GSSLLLSCRLLACTL (in isoform 2)"
FT /evidence="ECO:0000303|Ref.4"
FT /id="VSP_028595"
FT VAR_SEQ 1397..1749
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.4"
FT /id="VSP_028598"
FT VARIANT 436
FT /note="E -> G (in dbSNP:rs3810964)"
FT /evidence="ECO:0000269|Ref.3"
FT /id="VAR_035358"
FT VARIANT 581
FT /note="G -> S (in dbSNP:rs35152544)"
FT /id="VAR_035359"
FT VARIANT 717
FT /note="L -> P (in dbSNP:rs2998139)"
FT /evidence="ECO:0000269|Ref.3"
FT /id="VAR_035360"
FT VARIANT 1038
FT /note="R -> W (in dbSNP:rs35604376)"
FT /id="VAR_061786"
FT VARIANT 1332
FT /note="A -> T (in dbSNP:rs11101642)"
FT /id="VAR_051902"
FT CONFLICT 346
FT /note="L -> P (in Ref. 3; BAD12625)"
FT /evidence="ECO:0000305"
FT CONFLICT 806
FT /note="V -> D (in Ref. 3; BAD12625)"
FT /evidence="ECO:0000305"
FT CONFLICT 925
FT /note="A -> G (in Ref. 3; BAD12625)"
FT /evidence="ECO:0000305"
FT CONFLICT 971
FT /note="E -> G (in Ref. 3; BAD12625)"
FT /evidence="ECO:0000305"
FT CONFLICT 1072
FT /note="S -> P (in Ref. 3; BAD12625)"
FT /evidence="ECO:0000305"
FT CONFLICT 1084
FT /note="A -> V (in Ref. 3; BAD12625)"
FT /evidence="ECO:0000305"
FT CONFLICT 1260
FT /note="A -> T (in Ref. 3; BAD12625)"
FT /evidence="ECO:0000305"
FT CONFLICT 1315
FT /note="I -> T (in Ref. 3; BAD12625)"
FT /evidence="ECO:0000305"
FT CONFLICT 1468
FT /note="S -> G (in Ref. 3; BAD12625)"
FT /evidence="ECO:0000305"
FT CONFLICT 1624
FT /note="K -> R (in Ref. 3; BAD12625)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1749 AA; 191397 MW; FB5F6C6692BBCB06 CRC64;
MQAMDPAAAD LYEEDGKDLD FYDFEPLPTL PEDEENVSLA DILSLRDRGL SEQEAWAVCL
ECSLSMRSVA HAAIFQSLCI TPDTLAFNTS GNVCFMEQLS DDPEGAFVPP EFDVTGNTFE
AHIYSLGATL KAALEYVAEP TLEPRLSQDL EALLSRMQAE DPGDRPDLES IIALCEEKLQ
LTSSCRVCRS LSAVGRRVLS IESFGALQDV SESSWRERPA PGNAGPRRPP GDPSTDPEVL
PTPEGPESET SRGPRASPTK ALLSTPVRNG ESHSREGLAG LVLDAERTLG ELDRDALRRS
RLRKVQTFPR LLSDSPEATL CLPLTRGKSQ LPISELFSPD PRKAFLDRKN GLSSFQAQPK
CRLWPEQEPE HQLGRVPCAG RSTDRGPGVP GSPGQPETSH PSQGPAEAPA DPRDASGEAQ
TPRDDERIPE GARQLESAAA EQWVSLQDLL SQLGRPFREY ELWALCLACL RALQTRPEHP
AYLCLDSVLV AEDGAVLFQP PPANGSYDSF FLAPELAEER LVTEKASVYC VAAVLWTAAK
FSVPRNHKLA LPRRLKTLLL DMARRSAPER PSAAEAIKVC GSYLLQRGMD SRKILAHLRA
SICQVYQEEE TISLQNAFSV VELKPSVAPA PEPSPGFLPV NSDTGLVAVP GPVPGQHPCG
EEATQLPAAF TSEATHFKPI VLAQNASVAR DQPALAQEES EERGGQREGE GEEKLSLEAH
AGSPSLKTPD GPVPGPGPQG AAPEPLGASV QRDSAQGRPC PPPQAPANQP EGASSAAPGS
PVPAPPTKAS ALPVEQGPAE PIPPGVASGG LRPDALGPTT AHHGPRHPPK PPRSKATERP
GQEPEGPGAT PAGERDDQSP DSVPERPRPA DRRLCLPCVD ASPLPGRTAC PSLQEATRLI
QEEFAFDGYL DNGLEALIMG EYIFALKDLT FATFCGAISE KFCDLYWDEK LLQNLFKVVN
GQASPSPSTA EEAGSQLEGS QSPRSPSSKR PSLHRLGKEK PAMARTSSRA PCSPTSVSDV
DSDALSRGNF EVGFRPQRSV KAERAQQPEA GEDRRPAGGA SDVEAVTRLA RSKGVGPALS
PGPAGFQSCS PGWCSAFYEA DCFGADVHNY VKDLGRQQAD GALPDAQSPE LEQQLMMEKR
NYRKTLKFYQ KLLQKEKRNK GSDVKTMLSK LKGQLEEMKS RVQFLSLVKK YLQVMYAERW
GLEPCTLPVI VNIAAAPCDT LDFSPLDESS SLIFYNVNKH PGGRQKARIL QAGTPLGLMA
YLYSSDAFLE GYVQQFLYTF RYFCTPHDFL HFLLDRINST LTRAHQDPTS TFTKIYRRSL
CVLQAWVEDC YAVDFPRNSG LLGKLEDFIS SKILPLDGSA KHLLGLLEVG MDRRAEGNPR
GTDLENPREA EEDARPFNAL CKRLSEDGIS RKSFPWRLPR GNGLVLPPHK ERPYTIAAAL
PKPCFLEDFY GPCAKTSEKG PYFLTEYSTH QLFSQLTLLQ QELFQKCHPV HFLNSRALGV
MDKSTAIPKA SSSESLSAKT CSLFLPNYVQ DKYLLQLLRN ADDVSTWVAA EIVTSHTSKL
QVNLLSKFLL IAKSCYEQRN FATAMQILSG LEHLAVRQSP AWRILPAKIA EVMEELKAVE
VFLKSDSLCL MEGRRFRAQP TLPSAHLLAM HIQQLETGGF TMTNGAHRWS KLRNIAKVVS
QVHAFQENPY TFSPDPKLQS YLKQRIARFS GADISTLAAD SRANFHQVSS EKHSRKIQDK
LRRMKATFQ
