ID   KNH1_CANGA              Reviewed;         265 AA.
AC   O74684;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Cell wall synthesis protein KNH1;
DE   Flags: Precursor;
GN   Name=KNH1; OrderedLocusNames=CAGL0H07997g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=9748432; DOI=10.1128/jb.180.19.5020-5029.1998;
RA   Nagahashi S., Lussier M., Bussey H.;
RT   "Isolation of Candida glabrata homologs of the Saccharomyces cerevisiae
RT   KRE9 and KNH1 genes and their involvement in cell wall beta-1,6-glucan
RT   synthesis.";
RL   J. Bacteriol. 180:5020-5029(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in cell wall beta(1->6) glucan synthesis.
CC       {ECO:0000269|PubMed:9748432}.
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000305}.
CC   -!- PTM: O-glycosylated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the KRE9/KNH1 family. {ECO:0000305}.
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DR   EMBL; AF064252; AAC64009.1; -; Genomic_DNA.
DR   EMBL; CR380954; CAG60079.1; -; Genomic_DNA.
DR   RefSeq; XP_447146.1; XM_447146.1.
DR   AlphaFoldDB; O74684; -.
DR   STRING; 5478.XP_447146.1; -.
DR   EnsemblFungi; CAG60079; CAG60079; CAGL0H07997g.
DR   GeneID; 2888825; -.
DR   KEGG; cgr:CAGL0H07997g; -.
DR   CGD; CAL0129512; KNH1.
DR   VEuPathDB; FungiDB:CAGL0H07997g; -.
DR   eggNOG; ENOG502S28F; Eukaryota.
DR   HOGENOM; CLU_063732_1_0_1; -.
DR   InParanoid; O74684; -.
DR   OMA; YIQIFAQ; -.
DR   Proteomes; UP000002428; Chromosome H.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0006078; P:(1->6)-beta-D-glucan biosynthetic process; IEA:EnsemblFungi.
DR   GO; GO:0042546; P:cell wall biogenesis; IEA:InterPro.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   InterPro; IPR045328; Kre9/Knh1.
DR   InterPro; IPR018466; Kre9/Knh1-like_N.
DR   InterPro; IPR008659; Kre9/Knh1_C.
DR   PANTHER; PTHR28154; PTHR28154; 1.
DR   Pfam; PF10342; GPI-anchored; 1.
DR   Pfam; PF05390; KRE9; 1.
PE   3: Inferred from homology;
KW   Cell wall; Cell wall biogenesis/degradation; Glycoprotein;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..14
FT                   /evidence="ECO:0000255"
FT   CHAIN           15..265
FT                   /note="Cell wall synthesis protein KNH1"
FT                   /id="PRO_0000016850"
FT   REGION          231..265
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   265 AA;  29047 MW;  6A13BCD6BC0AE2BC CRC64;
     MLSIILLLMQ LVAADIAVVG PSLDQSFDAS GGTAKIPIQW LFTPNTPSQD DFTSLTFSLC
     SGPNYKIEAF KVIGKLSDIG TTDFEAEVSQ SVGANGYYYV QIYAATTDGY TIHYSPRFKL
     TGMTGSKLPD TLLITAPPTP ETRVTTGDLG ATIDSKSFDI PYGEQNGKAK FAPMQTQPGT
     KITATTWSRR YATSAVSFFT SLTATPVQHT TLTPGWSYYI SSDYNYAPPA PFPSDNGGWY
     DPKKRQSFTT RKLNMDKLRK RRQTS