KNH1_YEAST
ID KNH1_YEAST Reviewed; 268 AA.
AC P50112; D6VRU6; Q07354;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 15-JUL-1999, sequence version 2.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Cell wall synthesis protein KNH1;
DE Flags: Precursor;
GN Name=KNH1; OrderedLocusNames=YDL049C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8810042;
RX DOI=10.1002/(sici)1097-0061(19960615)12:7<683::aid-yea959>3.0.co;2-8;
RA Dijkgraaf G.J.P., Brown J.L., Bussey H.;
RT "The KNH1 gene of Saccharomyces cerevisiae is a functional homolog of
RT KRE9.";
RL Yeast 12:683-692(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169867;
RA Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA Mewes H.-W., Zollner A., Zaccaria P.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL Nature 387:75-78(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
CC -!- FUNCTION: Involved in cell wall beta(1->6) glucan synthesis.
CC -!- SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000305}.
CC -!- PTM: O-glycosylated.
CC -!- SIMILARITY: Belongs to the KRE9/KNH1 family. {ECO:0000305}.
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DR EMBL; U31538; AAC49530.1; -; Genomic_DNA.
DR EMBL; Z74097; CAA98611.1; -; Genomic_DNA.
DR EMBL; BK006938; DAA11806.1; -; Genomic_DNA.
DR PIR; S67583; S67583.
DR RefSeq; NP_010234.1; NM_001180108.1.
DR AlphaFoldDB; P50112; -.
DR BioGRID; 32009; 61.
DR DIP; DIP-4996N; -.
DR IntAct; P50112; 5.
DR STRING; 4932.YDL049C; -.
DR PaxDb; P50112; -.
DR EnsemblFungi; YDL049C_mRNA; YDL049C; YDL049C.
DR GeneID; 851511; -.
DR KEGG; sce:YDL049C; -.
DR SGD; S000002207; KNH1.
DR VEuPathDB; FungiDB:YDL049C; -.
DR eggNOG; ENOG502S28F; Eukaryota.
DR GeneTree; ENSGT00940000176711; -.
DR HOGENOM; CLU_063732_1_0_1; -.
DR InParanoid; P50112; -.
DR OMA; YIQIFAQ; -.
DR BioCyc; YEAST:G3O-29468-MON; -.
DR PRO; PR:P50112; -.
DR Proteomes; UP000002311; Chromosome IV.
DR RNAct; P50112; protein.
DR GO; GO:0005576; C:extracellular region; IDA:SGD.
DR GO; GO:0000324; C:fungal-type vacuole; HDA:SGD.
DR GO; GO:0006078; P:(1->6)-beta-D-glucan biosynthetic process; IMP:SGD.
DR GO; GO:0042546; P:cell wall biogenesis; IEA:InterPro.
DR GO; GO:0031505; P:fungal-type cell wall organization; IBA:GO_Central.
DR InterPro; IPR045328; Kre9/Knh1.
DR InterPro; IPR018466; Kre9/Knh1-like_N.
DR InterPro; IPR008659; Kre9/Knh1_C.
DR PANTHER; PTHR28154; PTHR28154; 1.
DR Pfam; PF10342; GPI-anchored; 1.
DR Pfam; PF05390; KRE9; 1.
PE 3: Inferred from homology;
KW Cell wall; Cell wall biogenesis/degradation; Glycoprotein;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..268
FT /note="Cell wall synthesis protein KNH1"
FT /id="PRO_0000016851"
FT CONFLICT 238
FT /note="Missing (in Ref. 1)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 268 AA; 29753 MW; B7B5C12A27AB8496 CRC64;
MLIVLFLTLF CSVVFRTAYC DVAIVAPEPN SVYDLSGTSQ AVVKVKWMHT DNTPQEKDFV
RYTFTLCSGT NAMIEAMATL QTLSASDLTD NEFNAIIENT VGTDGVYFIQ VFAQTAIGYT
IHYTNRFKLK GMIGTKAANP SMITIAPEAQ TRITTGDVGA TIDSKSFTVP YNLQTGVVKY
APMQLQPATK VTAKTWKRKY ATSEVTYYYT LRNSVDQHTT VTPGWSYIIT ADSNYATPAP
MPADNGGWYN PRKRLSLTAR KVNALRHR
