ARAH_ECOLI
ID ARAH_ECOLI Reviewed; 328 AA.
AC P0AE26; P08532; P76304; P76305;
DT 01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 2.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=L-arabinose transport system permease protein AraH;
GN Name=araH; OrderedLocusNames=b4460, JW1887;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=BEK 180;
RX PubMed=2445996; DOI=10.1016/0022-2836(87)90607-3;
RA Scripture J.B., Voelker C., Miller S., O'Donnell R.T., Polgar L., Rade J.,
RA Horazdovsky B.F., Hogg R.W.;
RT "High-affinity L-arabinose transport operon. Nucleotide sequence and
RT analysis of gene products.";
RL J. Mol. Biol. 197:37-46(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9097040; DOI=10.1093/dnares/3.6.379;
RA Itoh T., Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K.,
RA Kasai H., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T.,
RA Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S., Nakamura Y.,
RA Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y.,
RA Sivasundaram S., Tagami H., Takeda J., Takemoto K., Wada C., Yamamoto Y.,
RA Horiuchi T.;
RT "A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT the 40.1-50.0 min region on the linkage map.";
RL DNA Res. 3:379-392(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP SEQUENCE REVISION.
RX PubMed=16397293; DOI=10.1093/nar/gkj405;
RA Riley M., Abe T., Arnaud M.B., Berlyn M.K.B., Blattner F.R.,
RA Chaudhuri R.R., Glasner J.D., Horiuchi T., Keseler I.M., Kosuge T.,
RA Mori H., Perna N.T., Plunkett G. III, Rudd K.E., Serres M.H., Thomas G.H.,
RA Thomson N.R., Wishart D., Wanner B.L.;
RT "Escherichia coli K-12: a cooperatively developed annotation snapshot
RT -- 2005.";
RL Nucleic Acids Res. 34:1-9(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 161-328.
RC STRAIN=K12 / CSH7;
RX PubMed=8045430; DOI=10.1016/0378-1119(94)90316-6;
RA Kaasen I., McDougall J., Stroem A.R.;
RT "Analysis of the otsBA operon for osmoregulatory trehalose synthesis in
RT Escherichia coli and homology of the OtsA and OtsB proteins to the yeast
RT trehalose-6-phosphate synthase/phosphatase complex.";
RL Gene 145:9-15(1994).
RN [7]
RP INDUCTION.
RX PubMed=2231717; DOI=10.1016/s0022-2836(05)80163-9;
RA Hendrickson W., Stoner C., Schleif R.;
RT "Characterization of the Escherichia coli araFGH and araJ promoters.";
RL J. Mol. Biol. 215:497-510(1990).
RN [8]
RP SUBCELLULAR LOCATION.
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
CC -!- FUNCTION: Part of the binding-protein-dependent transport system for L-
CC arabinose. Probably responsible for the translocation of the substrate
CC across the membrane.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:15919996}.
CC -!- INDUCTION: Induced by arabinose. Transcription is dependent on the
CC transcription factor AraC, the cAMP receptor protein (CRP) and cAMP.
CC {ECO:0000269|PubMed:2231717}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. AraH/RbsC subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA15719.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAA29478.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAA48911.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X06091; CAA29478.1; ALT_INIT; Genomic_DNA.
DR EMBL; U00096; AAT48138.2; -; Genomic_DNA.
DR EMBL; AP009048; BAA15719.1; ALT_INIT; Genomic_DNA.
DR EMBL; X69160; CAA48911.1; ALT_INIT; Genomic_DNA.
DR PIR; S01075; S01075.
DR RefSeq; WP_000100205.1; NZ_SSZK01000001.1.
DR RefSeq; YP_026162.2; NC_000913.3.
DR AlphaFoldDB; P0AE26; -.
DR BioGRID; 4262240; 16.
DR ComplexPortal; CPX-4314; Arabinose ABC transporter complex.
DR STRING; 511145.b4460; -.
DR TCDB; 3.A.1.2.2; the atp-binding cassette (abc) superfamily.
DR jPOST; P0AE26; -.
DR PaxDb; P0AE26; -.
DR PRIDE; P0AE26; -.
DR EnsemblBacteria; AAT48138; AAT48138; b4460.
DR EnsemblBacteria; BAA15719; BAA15719; BAA15719.
DR GeneID; 58389798; -.
DR GeneID; 948923; -.
DR KEGG; ecj:JW1887; -.
DR KEGG; eco:b4460; -.
DR PATRIC; fig|1411691.4.peg.351; -.
DR EchoBASE; EB0057; -.
DR eggNOG; COG1172; Bacteria.
DR HOGENOM; CLU_028880_4_1_6; -.
DR InParanoid; P0AE26; -.
DR OMA; VFTTITN; -.
DR PhylomeDB; P0AE26; -.
DR BioCyc; EcoCyc:ARAH-MON; -.
DR BioCyc; MetaCyc:ARAH-MON; -.
DR PRO; PR:P0AE26; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0055052; C:ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing; IC:ComplexPortal.
DR GO; GO:0016021; C:integral component of membrane; IDA:EcoCyc.
DR GO; GO:0016020; C:membrane; IC:ComplexPortal.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:0015147; F:L-arabinose transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015751; P:arabinose transmembrane transport; IBA:GO_Central.
DR GO; GO:0042882; P:L-arabinose transmembrane transport; IC:ComplexPortal.
DR InterPro; IPR001851; ABC_transp_permease.
DR Pfam; PF02653; BPD_transp_2; 1.
PE 2: Evidence at transcript level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..328
FT /note="L-arabinose transport system permease protein AraH"
FT /id="PRO_0000059951"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 220..240
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..296
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 297..317
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 328 AA; 34211 MW; 72B778D741FB6938 CRC64;
MSSVSTSGSG APKSSFSFGR IWDQYGMLVV FAVLFIACAI FVPNFATFIN MKGLGLAISM
SGMVACGMLF CLASGDFDLS VASVIACAGV TTAVVINLTE SLWIGVAAGL LLGVLCGLVN
GFVIAKLKIN ALITTLATMQ IVRGLAYIIS DGKAVGIEDE SFFALGYANW FGLPAPIWLT
VACLIIFGLL LNKTTFGRNT LAIGGNEEAA RLAGVPVVRT KIIIFVLSGL VSAIAGIILA
SRMTSGQPMT SIGYELIVIS ACVLGGVSLK GGIGKISYVV AGILILGTVE NAMNLLNISP
FAQYVVRGLI LLAAVIFDRY KQKAKRTV
