ID   KNIR_DROVI              Reviewed;         481 AA.
AC   Q24753;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 112.
DE   RecName: Full=Zygotic gap protein knirps;
DE   AltName: Full=Nuclear receptor subfamily 0 group A member 1;
GN   Name=kni; Synonyms=NR0A1;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7969130; DOI=10.1128/mcb.14.12.7899-7908.1994;
RA   Gerwin N., la Rosee A., Sauer F., Halbritter H.P., Neumann M., Jackle H.,
RA   Nauber U.;
RT   "Functional and conserved domains of the Drosophila transcription factor
RT   encoded by the segmentation gene knirps.";
RL   Mol. Cell. Biol. 14:7899-7908(1994).
CC   -!- FUNCTION: Transcriptional repressor. Binds to multiple sites in the eve
CC       stripe 3 enhancer element. Plays an essential role in the segmentation
CC       process both by refining the expression patterns of gap genes and by
CC       establishing pair-rules stripes of gene expression (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR0
CC       subfamily. {ECO:0000305}.
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DR   EMBL; L36177; AAA66190.1; -; Genomic_DNA.
DR   PIR; A56346; A56346.
DR   AlphaFoldDB; Q24753; -.
DR   SMR; Q24753; -.
DR   STRING; 7244.FBpp0228190; -.
DR   eggNOG; ENOG502QURP; Eukaryota.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00399; ZnF_C4; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Metal-binding; Nucleus; Receptor;
KW   Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..481
FT                   /note="Zygotic gap protein knirps"
FT                   /id="PRO_0000053744"
FT   DNA_BIND        2..78
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         5..25
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         42..66
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   REGION          100..161
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          231..294
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          308..336
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          420..442
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        122..151
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        233..262
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   481 AA;  51031 MW;  C4254ACB23201299 CRC64;
     MNQTCKVCGE PAAGFHFGAF TCEGCKSFFG RSYNNISTIS ECKNDGKCII DKKNRTTCKA
     CRLRKCYNVG MSKGGSRYGR RSNWFKIHCL LQEHEQAAAA AAGKAPGHAT GSPMSSPGFG
     DLAAHLQQQQ QQHQQQQQQQ HQHQQQQQRH PHLPPLLGYT GYHLPEHFGA RHPADAAAAA
     AALPFFSMMA TPQSAFQLPP HLLFPGYHAS AAAAAAADAA YRQEMYKHRQ SVDSAASAES
     HSRYTPPTVA TVPQQSQPQP AASPIDVCLG ADDDVQSQHS HSHSHSQSQS PHTIHTPVAI
     RATPPQQLLP GLTTASHSSS ASPTPSKSQS SSPLSFTAKM QSLSPVSVCS IGGETAAANA
     AASAAAAAQD GPMDLSMKTS RSSVHSFNDS DVCSLQDEHE LAARRKYYQL EAECTTITNT
     TNSCSSSTST SSSNSSTSST EAAVAVKRQK LNPIGGESPP FGGFAVTHNA SSAMRSIFVC
     V