ID   KNOB_PLAFA              Reviewed;         473 AA.
AC   P13817;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Knob-associated histidine-rich protein;
DE            Short=HRPI;
DE            Short=KAHRP;
DE   Flags: Precursor; Fragment;
OS   Plasmodium falciparum.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=5833;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2448620; DOI=10.1016/0166-6851(87)90144-7;
RA   Ellis J., Irving D.O., Wellems T.E., Howard R.J., Cross G.A.M.;
RT   "Structure and expression of the knob-associated histidine-rich protein of
RT   Plasmodium falciparum.";
RL   Mol. Biochem. Parasitol. 26:203-214(1987).
CC   -!- FUNCTION: KAHRP might mimick human histidine-rich glycoproteins to
CC       anchor host thrombospondin or a parasite analog in a binding complex
CC       with the endothelial cell receptor.
CC   -!- SUBCELLULAR LOCATION: Secreted. Note=Cytoplasmic side of the membrane
CC       of infected erythrocytes.
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DR   EMBL; M19028; AAA29630.1; -; mRNA.
DR   PIR; A54494; A54494.
DR   AlphaFoldDB; P13817; -.
DR   BMRB; P13817; -.
DR   DrugBank; DB11638; Artenimol.
DR   VEuPathDB; PlasmoDB:PF3D7_0202000; -.
DR   VEuPathDB; PlasmoDB:Pf7G8-2_000050200; -.
DR   VEuPathDB; PlasmoDB:Pf7G8_020006800; -.
DR   VEuPathDB; PlasmoDB:PfCD01_020007100; -.
DR   VEuPathDB; PlasmoDB:PfDd2_020004900; -.
DR   VEuPathDB; PlasmoDB:PfGA01_020005100; -.
DR   VEuPathDB; PlasmoDB:PfGB4_020005100; -.
DR   VEuPathDB; PlasmoDB:PfGN01_020007500; -.
DR   VEuPathDB; PlasmoDB:PfHB3_020006800; -.
DR   VEuPathDB; PlasmoDB:PfIT_020006800; -.
DR   VEuPathDB; PlasmoDB:PfKH01_020007400; -.
DR   VEuPathDB; PlasmoDB:PfKH02_020006100; -.
DR   VEuPathDB; PlasmoDB:PfML01_000030600; -.
DR   VEuPathDB; PlasmoDB:PfNF135_020008400; -.
DR   VEuPathDB; PlasmoDB:PfNF166_020007300; -.
DR   VEuPathDB; PlasmoDB:PfNF54_020007000; -.
DR   VEuPathDB; PlasmoDB:PfSD01_020007600; -.
DR   VEuPathDB; PlasmoDB:PfSN01_020005100; -.
DR   VEuPathDB; PlasmoDB:PfTG01_020007100; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR040805; EMP3/KAHRP_N.
DR   Pfam; PF17986; EKAL; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Malaria; Repeat; Secreted; Signal.
FT   SIGNAL          1..34
FT                   /evidence="ECO:0000255"
FT   CHAIN           35..>473
FT                   /note="Knob-associated histidine-rich protein"
FT                   /id="PRO_0000024544"
FT   REGION          57..143
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          347..473
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        57..89
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        119..136
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        352..381
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        390..409
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        418..473
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        42
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   NON_TER         473
SQ   SEQUENCE   473 AA;  53191 MW;  A97F2D3DA7675E2E CRC64;
     MKSFKNKNTL RRKKAFPVFT KILLVSFLVW VLKCSNNCNN GNGSGDSFDF RNKRTLAQKQ
     HEHHHHHHHQ HQHQHQAPHQ AHHHHHHGEV NHQAPQVHQQ VHGQDQAHHH HHHHHHQLQP
     QQLQGTVANP PSNEPVVKTQ VFREARPGGG FKAYEEKYES KHYKLKENVV DGKKDCDEKY
     EAANYAFSEE CPYTVNDYSQ ENGPNIFALR KRFPLGMNDE DEEGKEALAI KDKLPGGLDE
     YQNQLYGICN ETCTTCGPAA IDYVPADAPN GYAYGGSAHD GSHGNLRGHG NKGSEGYGYE
     APYNPGFNGA PGSNGMQNYV PPHGAGYSAP YGVPHGAAHG SRYSSFSSVN KYGKHGDEKH
     HSSKKHEGND GEGEKKKKSK KHKDHDGEKK KSKKHKDNED AESVKSKKHK SHDCEKKKSK
     KHKDNEDAES VKSKKSVKEK GEKHNGKKPC SKKTNEENKN KEKTNNLKSD GSK