ID   KNOB_PLAFD              Reviewed;         277 AA.
AC   P05229;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   25-MAY-2022, entry version 51.
DE   RecName: Full=Knob-associated histidine-rich protein;
DE            Short=KAHRP;
DE   Flags: Fragment;
OS   Plasmodium falciparum (isolate CDC / Honduras).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=5836;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3301326; DOI=10.1002/j.1460-2075.1987.tb02383.x;
RA   Ardeshir F., Flint J.E., Matsumoto Y., Aikawa M., Reese R.T., Stamley H.;
RT   "cDNA sequence encoding a Plasmodium falciparum protein associated with
RT   knobs and localization of the protein to electron-dense regions in
RT   membranes of infected erythrocytes.";
RL   EMBO J. 6:1421-1427(1987).
CC   -!- FUNCTION: KAHRP might mimick human histidine-rich glycoproteins to
CC       anchor host thrombospondin or a parasite analog in a binding complex
CC       with the endothelial cell receptor.
CC   -!- SUBCELLULAR LOCATION: Secreted. Note=Cytoplasmic side of the membrane
CC       of infected erythrocytes.
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DR   EMBL; Y00063; CAA68270.1; -; mRNA.
DR   PIR; S14431; S14431.
DR   AlphaFoldDB; P05229; -.
DR   BMRB; P05229; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Malaria; Repeat; Secreted.
FT   CHAIN           <1..>277
FT                   /note="Knob-associated histidine-rich protein"
FT                   /id="PRO_0000217189"
FT   REGION          95..114
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          162..277
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        167..196
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        205..224
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        233..268
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT   NON_TER         277
SQ   SEQUENCE   277 AA;  30423 MW;  66C215DAF3AB36FF CRC64;
     AFSEECPYTV NDYSQENGPN IFALRKRFPL GMNDEDEEGK EALAIKDKLP GGLDEYQNQL
     YGICNETCTT CGPAAIDYVP ADAPNGYAYG GSAHDGSHGN LRGHDNKGSE GYGYEAPYNP
     GFNGAPGSNG MQNYVPPHGA GYSAPYGVPH GAAHGSRYSS FSSVNKYGKH GDEKHHSSKK
     HEGNDGEGEK KKKSKKHKDH DGEKKKSKKH KDNEDAESVK SKKHKSHDCE KKKSKKHKDN
     EDAESVKSKK SVKEKGEKHN GKKPCSKKTN EEKKKKK