ID   KNOB_PLAFN              Reviewed;         657 AA.
AC   P06719;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1988, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Knob-associated histidine-rich protein;
DE            Short=KAHRP;
DE   Flags: Precursor;
GN   Name=SD17;
OS   Plasmodium falciparum (isolate NF7 / Ghana).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=5842;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3301325; DOI=10.1002/j.1460-2075.1987.tb02382.x;
RA   Triglia T., Stahl H.-D., Crewther P.E., Scanlon D.B., Brown G.V.,
RA   Anders R.F., Kemp D.J.;
RT   "The complete sequence of the gene for the knob-associated histidine-rich
RT   protein from Plasmodium falciparum.";
RL   EMBO J. 6:1413-1419(1987).
CC   -!- FUNCTION: KAHRP might mimick human histidine-rich glycoproteins to
CC       anchor host thrombospondin or a parasite analog in a binding complex
CC       with the endothelial cell receptor.
CC   -!- SUBCELLULAR LOCATION: Secreted. Note=Cytoplasmic side of the membrane
CC       of infected erythrocytes.
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DR   EMBL; Y00060; CAA68268.1; -; Genomic_DNA.
DR   PIR; A29454; A29454.
DR   AlphaFoldDB; P06719; -.
DR   BMRB; P06719; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR040805; EMP3/KAHRP_N.
DR   Pfam; PF17986; EKAL; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Malaria; Repeat; Secreted; Signal.
FT   SIGNAL          1..34
FT                   /evidence="ECO:0000255"
FT   CHAIN           35..657
FT                   /note="Knob-associated histidine-rich protein"
FT                   /id="PRO_0000024546"
FT   REGION          57..138
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          282..301
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          352..657
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        57..93
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        109..124
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        355..384
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        393..412
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        421..454
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        467..491
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        492..512
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        521..536
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        551..575
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        576..641
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        42
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   657 AA;  71941 MW;  F69E1B9CCF98F946 CRC64;
     MKSFKNKNTL RRKKAFPVFT KILLVSFLVW VLKCSNNCNN GNGSGDSFDF RNKRTLAQKQ
     HEHHHHHHHH HHHQHQAPHQ APHQAHHHHH HGEVNHQAPQ VHQQVHGQDQ AHHHHHHHHH
     HLHPQQPQGT VANPPSNEPV VKTQVFREAR PGGGFKAYEE KYESKHYKLK ENVVDGKKDC
     DEKYEAANYA FSEECPYTVN DYSQENGPNI FALRKRFPLG MNDEDEEGKE ALAIKDKLPG
     GLDEYQNQLY GICNETCTTC GPAAIDYVPA DAPNGYAYGG SAHDGSHGNL RGHDNKGSEG
     YGYEAPYNPG FNGAPGSNGM QNYVHPWSGY SAPYGVPHGA AHGSRYSSFS SVNKYGKHGD
     EKHHSSKKHE GNDGEGEKKK KSKKHKDHDG EKKKSKKHKD NEDAESVKSK KHKSHDCEKK
     KSKKHKDNED AESVKSKKVL KKREKSIMEK NHAAKKLTKK IKIKKKTNNS KSDGSKAHEK
     KENETKNTAG ENKKVDSTSA DNKSTNAATP GAKDKTQGGK TDKTGASTNA ATNKGQCAAE
     GATKGATKEA STSKEATKEA STSKEATKEA STSKEATKEA STSKGATKEA STTEGATKGA
     STTAGSTTGA TTGANAVQSK DETADKNAAN NGEQVMSRGQ AQLQEAGKKK KKRGCCG