ID   KORA_ARCFU              Reviewed;         346 AA.
AC   O29781;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=2-oxoglutarate synthase subunit KorA;
DE            EC=1.2.7.3;
DE   AltName: Full=2-ketoglutarate oxidoreductase alpha chain;
DE            Short=KOR;
DE   AltName: Full=2-oxoglutarate-ferredoxin oxidoreductase subunit alpha;
GN   Name=korA; OrderedLocusNames=AF_0469;
OS   Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC
OS   100126 / VC-16).
OC   Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae;
OC   Archaeoglobus.
OX   NCBI_TaxID=224325;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16;
RX   PubMed=9389475; DOI=10.1038/37052;
RA   Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L.,
RA   Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D.,
RA   Quackenbush J., Lee N.H., Sutton G.G., Gill S.R., Kirkness E.F.,
RA   Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N.,
RA   Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R.,
RA   Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D.,
RA   Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P.,
RA   Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M.,
RA   Smith H.O., Woese C.R., Venter J.C.;
RT   "The complete genome sequence of the hyperthermophilic, sulphate-reducing
RT   archaeon Archaeoglobus fulgidus.";
RL   Nature 390:364-370(1997).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-oxoglutarate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2
CC         + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] + succinyl-CoA;
CC         Xref=Rhea:RHEA:17297, Rhea:RHEA-COMP:10000, Rhea:RHEA-COMP:10001,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810,
CC         ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57292; EC=1.2.7.3;
CC   -!- SUBUNIT: Heterotetramer of the KorA, KorB, KorC and KorD subunits.
CC       {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE000782; AAB90768.1; -; Genomic_DNA.
DR   PIR; E69308; E69308.
DR   AlphaFoldDB; O29781; -.
DR   SMR; O29781; -.
DR   STRING; 224325.AF_0469; -.
DR   PRIDE; O29781; -.
DR   EnsemblBacteria; AAB90768; AAB90768; AF_0469.
DR   KEGG; afu:AF_0469; -.
DR   eggNOG; arCOG01607; Archaea.
DR   HOGENOM; CLU_017038_0_1_2; -.
DR   OMA; DFIQGDE; -.
DR   PhylomeDB; O29781; -.
DR   Proteomes; UP000002199; Chromosome.
DR   GO; GO:0047553; F:2-oxoglutarate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006082; P:organic acid metabolic process; IEA:UniProt.
DR   GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR   GO; GO:0044272; P:sulfur compound biosynthetic process; IEA:UniProt.
DR   CDD; cd07034; TPP_PYR_PFOR_IOR-alpha_like; 1.
DR   Gene3D; 3.40.50.920; -; 1.
DR   InterPro; IPR033412; PFOR_II.
DR   InterPro; IPR002880; Pyrv_Fd/Flavodoxin_OxRdtase_N.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   Pfam; PF17147; PFOR_II; 1.
DR   Pfam; PF01855; POR_N; 1.
DR   SUPFAM; SSF52518; SSF52518; 1.
DR   SUPFAM; SSF52922; SSF52922; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..346
FT                   /note="2-oxoglutarate synthase subunit KorA"
FT                   /id="PRO_0000099937"
SQ   SEQUENCE   346 AA;  37506 MW;  6D64A7CFD0D40478 CRC64;
     MEMELIQGNE AAVRGAINAG CNFFAGYPIT PSSEIAHGMA ELLPKFGGVF IQMEDEIASI
     SAVIGASMAG AVAMTATSGP GFSLMQEGMG YAAITESPVV IFNVMRAGPS TGIPTAPSQG
     DAMQARYGSH GDYPIVVLAP ASVKDMYYLT VEAFKIAFRF STPVIVLSDE IVGHMRESVA
     LPPLGEIESY EKRAKNLIDG RRRHRTGLVH TENGLPTTDL EEYEKLLRLL FAKFDDFRPM
     VRFEGEEGVL FVAYGSSYRL AKSSAKLLAE KGVSAGILKL ESLFPFPEDA VRRYSKKADL
     VVVPEMNAGQ VVKEVERVCC CRVKGVSYFG SLILPEKLVE IVEGEL