ID   KORA_METJA              Reviewed;         366 AA.
AC   Q57724;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=2-oxoglutarate synthase subunit KorA;
DE            EC=1.2.7.3;
DE   AltName: Full=2-ketoglutarate oxidoreductase alpha chain;
DE            Short=KOR;
DE   AltName: Full=2-oxoglutarate-ferredoxin oxidoreductase subunit alpha;
GN   Name=korA; OrderedLocusNames=MJ0276;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-oxoglutarate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2
CC         + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] + succinyl-CoA;
CC         Xref=Rhea:RHEA:17297, Rhea:RHEA-COMP:10000, Rhea:RHEA-COMP:10001,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810,
CC         ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57292; EC=1.2.7.3;
CC   -!- SUBUNIT: Heterotetramer of the KorA, KorB, KorC and KorD subunits.
CC       {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L77117; AAB98264.1; -; Genomic_DNA.
DR   PIR; E64334; E64334.
DR   AlphaFoldDB; Q57724; -.
DR   SMR; Q57724; -.
DR   STRING; 243232.MJ_0276; -.
DR   EnsemblBacteria; AAB98264; AAB98264; MJ_0276.
DR   KEGG; mja:MJ_0276; -.
DR   eggNOG; arCOG01607; Archaea.
DR   HOGENOM; CLU_017038_0_1_2; -.
DR   InParanoid; Q57724; -.
DR   OMA; DFIQGDE; -.
DR   PhylomeDB; Q57724; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0047553; F:2-oxoglutarate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006082; P:organic acid metabolic process; IEA:UniProt.
DR   GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR   GO; GO:0006979; P:response to oxidative stress; IBA:GO_Central.
DR   GO; GO:0044272; P:sulfur compound biosynthetic process; IEA:UniProt.
DR   CDD; cd07034; TPP_PYR_PFOR_IOR-alpha_like; 1.
DR   Gene3D; 3.40.50.920; -; 1.
DR   InterPro; IPR033412; PFOR_II.
DR   InterPro; IPR002880; Pyrv_Fd/Flavodoxin_OxRdtase_N.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   Pfam; PF17147; PFOR_II; 1.
DR   Pfam; PF01855; POR_N; 1.
DR   SUPFAM; SSF52518; SSF52518; 1.
DR   SUPFAM; SSF52922; SSF52922; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..366
FT                   /note="2-oxoglutarate synthase subunit KorA"
FT                   /id="PRO_0000099938"
SQ   SEQUENCE   366 AA;  41060 MW;  7C5E41EAD9EB6E78 CRC64;
     MKVEFMQGNQ ACAKGAIKAG CRFFAGYPIT PSTEIAEAMA RELPKVGGYY IQMEDEIGSI
     AAVIGASWGG LKAMTATSGP GFSLMQENIG FAYMTETPCV VVDIQRGGPS TGQPTMASQG
     DMMQCRWGSH GDYEVIALAP SSVQEMYDFT IMAFNYAEKY RIPVFVMADE IVGHMREKVI
     LHDNIEIINR KKPEEKPCKK PYPFDKLIPE MPVFGEGYNV HITGLTHDER GYPDVSPETH
     DKLVRRIVNK IRKNKDEIIK WEGENLDAEI VFVCYGSPSR TVKHAVRNLR EKGLDVGYIR
     LITVYPFPDD LLKKLKAKKV VVPEMNLGQI YYEVERVCKK AEEVILVDKI GGELHRPEEL
     ERAVLG