ID   KORA_METTH              Reviewed;         376 AA.
AC   O27112;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=2-oxoglutarate synthase subunit KorA;
DE            EC=1.2.7.3;
DE   AltName: Full=2-ketoglutarate oxidoreductase alpha chain;
DE            Short=KOR;
DE   AltName: Full=2-oxoglutarate-ferredoxin oxidoreductase subunit alpha;
GN   Name=korA; OrderedLocusNames=MTH_1033;
OS   Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS   10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX   PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA   Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA   Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA   Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA   Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA   Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT   functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-oxoglutarate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2
CC         + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] + succinyl-CoA;
CC         Xref=Rhea:RHEA:17297, Rhea:RHEA-COMP:10000, Rhea:RHEA-COMP:10001,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810,
CC         ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57292; EC=1.2.7.3;
CC   -!- SUBUNIT: Heterotetramer of the KorA, KorB, KorC and KorD subunits.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB85529.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE000666; AAB85529.1; ALT_INIT; Genomic_DNA.
DR   PIR; H69004; H69004.
DR   AlphaFoldDB; O27112; -.
DR   SMR; O27112; -.
DR   STRING; 187420.MTH_1033; -.
DR   EnsemblBacteria; AAB85529; AAB85529; MTH_1033.
DR   KEGG; mth:MTH_1033; -.
DR   PATRIC; fig|187420.15.peg.1016; -.
DR   HOGENOM; CLU_017038_0_1_2; -.
DR   OMA; DFIQGDE; -.
DR   Proteomes; UP000005223; Chromosome.
DR   GO; GO:0047553; F:2-oxoglutarate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006082; P:organic acid metabolic process; IEA:UniProt.
DR   GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR   GO; GO:0044272; P:sulfur compound biosynthetic process; IEA:UniProt.
DR   CDD; cd07034; TPP_PYR_PFOR_IOR-alpha_like; 1.
DR   Gene3D; 3.40.50.920; -; 1.
DR   InterPro; IPR033412; PFOR_II.
DR   InterPro; IPR002880; Pyrv_Fd/Flavodoxin_OxRdtase_N.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   Pfam; PF17147; PFOR_II; 1.
DR   Pfam; PF01855; POR_N; 1.
DR   SUPFAM; SSF52518; SSF52518; 1.
DR   SUPFAM; SSF52922; SSF52922; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..376
FT                   /note="2-oxoglutarate synthase subunit KorA"
FT                   /id="PRO_0000099939"
SQ   SEQUENCE   376 AA;  41377 MW;  2C9E0C53399EAD1F CRC64;
     MTEEYFIQGN DACARGAIKA GCRFFAGYPI TPSTEIAEEM ALLLPREGGV FVQMEDEIGA
     LGAVIGAVWS GVRGMTATSG PGFSLMQEHV GYAAMTETPL VIVNVQRGSP STGQPTMASQ
     SDMMQARWGS HGDYEIIALS PSSVQECFDF TVRAFNLAEE YRVPVMVMGD EIVGHMREKI
     TIPDRVKIRK RRGPSVPPEE FLPFSAPEDG VPEMPAFGDG YRIPVTGLTH DEGGYPDASN
     PEGHHRLVKR LCDKILRHRD RISDVQEELT EDAYITVISY GAPSRSVATA VKMAREDGVR
     AGYLKINTPW PFPETEVRAA AERSGKLLVV EMNLGQMFYE VQRVAAGMAE VELLPKIGGE
     IHRPEEILNM ILKMNR