ID   KORA_METTM              Reviewed;         375 AA.
AC   P80904; D9PXQ4;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 2.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=2-oxoglutarate synthase subunit KorA;
DE            EC=1.2.7.3;
DE   AltName: Full=2-ketoglutarate oxidoreductase alpha chain;
DE            Short=KOR;
DE   AltName: Full=2-oxoglutarate-ferredoxin oxidoreductase subunit alpha;
GN   Name=korA; OrderedLocusNames=MTBMA_c14150;
OS   Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM
OS   14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium
OS   thermoautotrophicum).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=79929;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 /
RC   Marburg;
RX   PubMed=20802048; DOI=10.1128/jb.00844-10;
RA   Liesegang H., Kaster A.K., Wiezer A., Goenrich M., Wollherr A., Seedorf H.,
RA   Gottschalk G., Thauer R.K.;
RT   "Complete genome sequence of Methanothermobacter marburgensis, a
RT   methanoarchaeon model organism.";
RL   J. Bacteriol. 192:5850-5851(2010).
RN   [2]
RP   PROTEIN SEQUENCE OF 2-21, BIOPHYSICOCHEMICAL PROPERTIES, AND SUBUNIT.
RC   STRAIN=ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 /
RC   Marburg;
RX   PubMed=9108258; DOI=10.1111/j.1432-1033.1997.00862.x;
RA   Tersteegen A., Linder D., Thauer R.K., Hedderich R.;
RT   "Structures and functions of four anabolic 2-oxoacid oxidoreductases in
RT   Methanobacterium thermoautotrophicum.";
RL   Eur. J. Biochem. 244:862-868(1997).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-oxoglutarate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2
CC         + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] + succinyl-CoA;
CC         Xref=Rhea:RHEA:17297, Rhea:RHEA-COMP:10000, Rhea:RHEA-COMP:10001,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810,
CC         ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57292; EC=1.2.7.3;
CC   -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC       pH dependence:
CC         Optimum pH is 9.0. {ECO:0000269|PubMed:9108258};
CC       Temperature dependence:
CC         Optimum temperature is 70 degrees Celsius.
CC         {ECO:0000269|PubMed:9108258};
CC   -!- SUBUNIT: Heterotetramer of the KorA, KorB, KorC and KorD subunits.
CC       {ECO:0000269|PubMed:9108258}.
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DR   EMBL; CP001710; ADL59002.1; -; Genomic_DNA.
DR   RefSeq; WP_013296214.1; NC_014408.1.
DR   AlphaFoldDB; P80904; -.
DR   SMR; P80904; -.
DR   STRING; 79929.MTBMA_c14150; -.
DR   EnsemblBacteria; ADL59002; ADL59002; MTBMA_c14150.
DR   GeneID; 9705124; -.
DR   KEGG; mmg:MTBMA_c14150; -.
DR   PATRIC; fig|79929.8.peg.1379; -.
DR   HOGENOM; CLU_017038_0_1_2; -.
DR   OMA; DFIQGDE; -.
DR   OrthoDB; 34838at2157; -.
DR   Proteomes; UP000000345; Chromosome.
DR   GO; GO:0047553; F:2-oxoglutarate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006082; P:organic acid metabolic process; IEA:UniProt.
DR   GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR   GO; GO:0044272; P:sulfur compound biosynthetic process; IEA:UniProt.
DR   CDD; cd07034; TPP_PYR_PFOR_IOR-alpha_like; 1.
DR   Gene3D; 3.40.50.920; -; 1.
DR   InterPro; IPR033412; PFOR_II.
DR   InterPro; IPR002880; Pyrv_Fd/Flavodoxin_OxRdtase_N.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   Pfam; PF17147; PFOR_II; 1.
DR   Pfam; PF01855; POR_N; 1.
DR   SUPFAM; SSF52518; SSF52518; 1.
DR   SUPFAM; SSF52922; SSF52922; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Oxidoreductase.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:9108258"
FT   CHAIN           2..375
FT                   /note="2-oxoglutarate synthase subunit KorA"
FT                   /id="PRO_0000099940"
SQ   SEQUENCE   375 AA;  40974 MW;  80B9815062C83132 CRC64;
     MTEEYFIQGN DACARGAISA GCRFFAGYPI TPSTEIAEEM AVLLPGEGGV FVQMEDEIGA
     LGAVIGAVWG GVKGMTATSG PGFSLMQEHV GYAAMTETPL VIVDVQRGSP STGQPTMASQ
     SDMMQARWGS HGDYEIIALS PSSVQECFDF TVRAFNLAEE YRVPVVVLSD EIVGHMREKI
     TIPDKVEIRK RKSPTSPPGE FIPFKPQGDF VPEMPAFGDG YRVPVTGLTH DERGYPDASN
     PEGHEKLVKR LCDKILNHRD KIVDVQKGWT DDADITVISY GAPSRSVATA VKMARSEGVR
     AGYIKINTPW PFPETEIREA AESSRKLLVV EMNLGQMFYE VQRVASGMAE VELLPKIGGE
     IHRPDEILNK IMGMK