ID   KORA_STRLI              Reviewed;         241 AA.
AC   P22405;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1991, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Protein KorA;
GN   Name=korA;
OS   Streptomyces lividans.
OG   Plasmid pIJ101.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1916;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3170481; DOI=10.1128/jb.170.10.4634-4651.1988;
RA   Kendall K.J., Cohen S.N.;
RT   "Complete nucleotide sequence of the Streptomyces lividans plasmid pIJ101
RT   and correlation of the sequence with genetic properties.";
RL   J. Bacteriol. 170:4634-4651(1988).
CC   -!- FUNCTION: Controls plasmid transfer and prevents the lethal effects of
CC       the tra/kilA gene. Repressor for the transcription of certain pIJ101
CC       promoters, including those the from kilA and kilB loci.
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DR   EMBL; M21778; AAA88411.1; -; Genomic_DNA.
DR   PIR; H31844; H31844.
DR   RefSeq; NP_040448.1; NC_001387.1.
DR   RefSeq; WP_010889920.1; NC_001387.1.
DR   AlphaFoldDB; P22405; -.
DR   SMR; P22405; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd07377; WHTH_GntR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.40.1410.10; -; 1.
DR   InterPro; IPR028978; Chorismate_lyase_/UTRA_dom_sf.
DR   InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR   InterPro; IPR011663; UTRA.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00392; GntR; 1.
DR   Pfam; PF07702; UTRA; 1.
DR   SMART; SM00345; HTH_GNTR; 1.
DR   SMART; SM00866; UTRA; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF64288; SSF64288; 1.
DR   PROSITE; PS50949; HTH_GNTR; 1.
PE   4: Predicted;
KW   DNA-binding; Plasmid; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..241
FT                   /note="Protein KorA"
FT                   /id="PRO_0000050651"
FT   DOMAIN          6..74
FT                   /note="HTH gntR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
FT   DNA_BIND        34..53
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
SQ   SEQUENCE   241 AA;  25318 MW;  9637AAF80F1845A5 CRC64;
     MSLERTPPYL QVVAALKAKI VSGELKHGDT LPSVRDLAAQ YEISTATAQK VHRTLKAEGL
     AEAKQGSATT VSTRRTLHRT AADRLESALS TGRIYADGEY AVITSAALAE PPEWVADLLG
     TESGQAVRRE RVTHSADDQP VSASVSWFSA DLAETVPALL VRDRIIGGTP SAIEAATGRR
     AVATEEATTA AAATEDQAAL LGVAAGAPVL LSRNVYVDAQ GDTIEVGESV APAGRWRVHR
     D