KORC_METTM
ID KORC_METTM Reviewed; 186 AA.
AC P80906; D9PXQ6;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 2.
DT 25-MAY-2022, entry version 77.
DE RecName: Full=2-oxoglutarate synthase subunit KorC;
DE EC=1.2.7.3;
DE AltName: Full=2-ketoglutarate oxidoreductase gamma chain;
DE Short=KOR;
DE AltName: Full=2-oxoglutarate-ferredoxin oxidoreductase subunit gamma;
GN Name=korC; OrderedLocusNames=MTBMA_c14170;
OS Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM
OS 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium
OS thermoautotrophicum).
OC Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX NCBI_TaxID=79929;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 /
RC Marburg;
RX PubMed=20802048; DOI=10.1128/jb.00844-10;
RA Liesegang H., Kaster A.K., Wiezer A., Goenrich M., Wollherr A., Seedorf H.,
RA Gottschalk G., Thauer R.K.;
RT "Complete genome sequence of Methanothermobacter marburgensis, a
RT methanoarchaeon model organism.";
RL J. Bacteriol. 192:5850-5851(2010).
RN [2]
RP PROTEIN SEQUENCE OF 1-20, BIOPHYSICOCHEMICAL PROPERTIES, AND SUBUNIT.
RC STRAIN=ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 /
RC Marburg;
RX PubMed=9108258; DOI=10.1111/j.1432-1033.1997.00862.x;
RA Tersteegen A., Linder D., Thauer R.K., Hedderich R.;
RT "Structures and functions of four anabolic 2-oxoacid oxidoreductases in
RT Methanobacterium thermoautotrophicum.";
RL Eur. J. Biochem. 244:862-868(1997).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-oxoglutarate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2
CC + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] + succinyl-CoA;
CC Xref=Rhea:RHEA:17297, Rhea:RHEA-COMP:10000, Rhea:RHEA-COMP:10001,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810,
CC ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57292; EC=1.2.7.3;
CC -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC pH dependence:
CC Optimum pH is 9.0. {ECO:0000269|PubMed:9108258};
CC Temperature dependence:
CC Optimum temperature is 70 degrees Celsius.
CC {ECO:0000269|PubMed:9108258};
CC -!- SUBUNIT: Heterotetramer of the KorA, KorB, KorC and KorD subunits.
CC {ECO:0000269|PubMed:9108258}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP001710; ADL59004.1; -; Genomic_DNA.
DR RefSeq; WP_013296216.1; NC_014408.1.
DR AlphaFoldDB; P80906; -.
DR SMR; P80906; -.
DR STRING; 79929.MTBMA_c14170; -.
DR EnsemblBacteria; ADL59004; ADL59004; MTBMA_c14170.
DR GeneID; 9705126; -.
DR KEGG; mmg:MTBMA_c14170; -.
DR PATRIC; fig|79929.8.peg.1381; -.
DR HOGENOM; CLU_087284_0_0_2; -.
DR OMA; EVSWMPS; -.
DR OrthoDB; 76505at2157; -.
DR Proteomes; UP000000345; Chromosome.
DR GO; GO:0047553; F:2-oxoglutarate synthase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.920.10; -; 1.
DR InterPro; IPR011894; PorC_KorC.
DR InterPro; IPR019752; Pyrv/ketoisovalerate_OxRed_cat.
DR InterPro; IPR002869; Pyrv_flavodox_OxRed_cen.
DR Pfam; PF01558; POR; 1.
DR SUPFAM; SSF53323; SSF53323; 1.
DR TIGRFAMs; TIGR02175; PorC_KorC; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Oxidoreductase.
FT CHAIN 1..186
FT /note="2-oxoglutarate synthase subunit KorC"
FT /id="PRO_0000099948"
SQ SEQUENCE 186 AA; 19977 MW; 3630FC5C7BDFC9BC CRC64;
MRKEIRIAGF GGQGVILAGI VLGKAASLYD GLYAVQTQSY GPEARGGASR AEVVISDEEI
DYPKVQSPDI LVAMSHQALL TYMDDLKAGG TLIVDPDMVI ENEIQDFVEE RNISYFRAPA
TRTAEEKVGI TIVANMVMIG ALTEATGVVS VRAAEEAIKN SVPPGTEEKN IMAFQAGREL
IMEGQK
